Comparison of the efficacy of the tumour necrosis factor alpha blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis.

abstract：BACKGROUND:Low serum vitamin D concentrations have been reported in several autoimmune disorders. OBJECTIVE:To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE). METHODS:378 patients from several European and Israeli cohorts were pool...

journal_title：Annals of the rheumatic diseases

authors： Amital H,Szekanecz Z,Szücs G,Dankó K,Nagy E,Csépány T,Kiss E,Rovensky J,Tuchynova A,Kozakova D,Doria A,Corocher N,Agmon-Levin N,Barak V,Orbach H,Zandman-Goddard G,Shoenfeld Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate quantitatively the mRNA expression levels of YKL-40, an established marker of rheumatoid and osteoarthritic cartilage degeneration in synovial fluid and serum, and a closely related molecule YKL-39, in articular chondrocytes. METHODS:cDNA array and online quantitative polymerase chain reaction...

journal_title：Annals of the rheumatic diseases

authors： Knorr T,Obermayr F,Bartnik E,Zien A,Aigner T

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To assess the incremental diagnostic value of spine MRI evaluated separately from and combined with sacroiliac joint (SIJ) MRI in non-radiographic axial spondyloarthritis (nr-axSpA) compared with SIJ MRI alone. METHODS:The study sample comprised two independent cohorts A/B of 130 consecutive patients aged ≤5...

journal_title：Annals of the rheumatic diseases

authors： Weber U,Zubler V,Zhao Z,Lambert RG,Chan SM,Pedersen SJ,Østergaard M,Rufibach K,Maksymowych WP

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To study maternal and fetal outcome of pregnancy in patients with lupus who were exposed to hydroxychloroquine (HCQ). METHODS:The case records of women (n = 33) exposed to HCQ during their pregnancies (n = 36) and of 53 control patients from a single lupus pregnancy centre were reviewed to determine lupus ac...

journal_title：Annals of the rheumatic diseases

authors： Buchanan NM,Toubi E,Khamashta MA,Lima F,Kerslake S,Hughes GR

更新日期：1996-07-01 00:00:00

abstract：:Mild iron deficiency induced by treatment with the iron chelator desferrioxamine reduced the incidence and severity of joint inflammation associated with adjuvant disease in rats but did not alter the local primary inflammatory response or the systemic sequelae. Both rats treated with desferrioxamine and control rats ...

journal_title：Annals of the rheumatic diseases

authors： Andrews FJ,Morris CJ,Kondratowicz G,Blake DR

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVES:To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis. METHODS:From incident cases of arthritis (n = 1305), patients who did not fulfil any classification criteria (undifferentiated arthritis (n...

journal_title：Annals of the rheumatic diseases

authors： Linn-Rasker SP,van der Helm-van Mil AH,van Gaalen FA,Kloppenburg M,de Vries RR,le Cessie S,Breedveld FC,Toes RE,Huizinga TW

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To study the value of antibodies to citrullinated proteins/peptides for predicting joint outcomes in patients with recent onset rheumatoid arthritis (RA). METHODS:191 patients with RA onset within the past year were followed up prospectively for five years. Serum samples obtained from 145 patients at baselin...

journal_title：Annals of the rheumatic diseases

authors： Meyer O,Labarre C,Dougados M,Goupille P,Cantagrel A,Dubois A,Nicaise-Roland P,Sibilia J,Combe B

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

journal_title：Annals of the rheumatic diseases

authors： Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:The aim of this pilot study was to compare clinical examination (CE) and ultrasound (US) with high field MRI (as the reference standard) for the detection of rearfoot and midtarsal joint synovitis and secondly tenosynovitis of the ankle tendons in patients with established rheumatoid arthritis (RA). METHODS...

journal_title：Annals of the rheumatic diseases

authors： Wakefield RJ,Freeston JE,O'Connor P,Reay N,Budgen A,Hensor EM,Helliwell PS,Emery P,Woodburn J

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. In most studies, neutrophils were analysed for mPR3 expression without prim...

journal_title：Annals of the rheumatic diseases

authors： van Rossum AP,Huitema MG,Stegeman CA,Bijl M,de Leeuw K,Van Leeuwen MA,Limburg PC,Kallenberg CG

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To develop widely accepted international severity score for children and adult patients with familial Mediterranean fever (FMF) that can be easily applied, in research and clinical practice. METHODS:Candidate severity criteria were suggested by several FMF expert physicians. After three rounds of Delphi surv...

journal_title：Annals of the rheumatic diseases

authors： Demirkaya E,Acikel C,Hashkes P,Gattorno M,Gul A,Ozdogan H,Turker T,Karadag O,Livneh A,Ben-Chetrit E,Ozen S,FMF Arthritis Vasculitis and Orphan disease Research in pediatric rheumatology (FAVOR).

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:To measure hyaluronic acid (HA) levels, which are raised in active rheumatoid arthritis (RA), in patients with early RA, and to assess the correlation with clinical and laboratory indices of disease activity and with subsequent radiographic erosive status. PATIENTS AND METHODS:Patients fulfilling ACR criter...

journal_title：Annals of the rheumatic diseases

authors： Majeed M,McQueen F,Yeoman S,McLean L

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE. METHODS:The relationship between maternal age at littering and frequency of AE was analy...

journal_title：Annals of the rheumatic diseases

authors： Weinreich S,Hoebe B,Ivanyi P

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation may contribute to accelerated atherosclerosis and increased arterial stiffness in patients with rheumatoid arthritis (RA). In addition to lowering cholesterol, statins have immunomodulatory effects which may be especially beneficial in patients with RA who have systemic immune a...

journal_title：Annals of the rheumatic diseases

authors： Van Doornum S,McColl G,Wicks IP

更新日期：2004-12-01 00:00:00

abstract：:The performance of four different assays for circulating immune complexes-the C1q solid phase method, one using protein A and one using anti-IgG, C1q PEG, and the 2% PEG method-were compared in 61 patients with early rheumatoid arthritis followed up for two years. There were weak but statistically significant correlat...

journal_title：Annals of the rheumatic diseases

authors： Reeback JS,Silman AJ,Holborow EJ,Maini RN,Hay FC

更新日期：1985-02-01 00:00:00

abstract：:OBJECTIVE: To examine the risk of major cardiovascular disease associated with non-steroidal anti-inflammatory drugs (NSAIDs) in a large 'real-world' contemporary rheumatoid arthritis (RA) cohort. METHODS: A longitudinal cohort study was conducted with use of Danish nationwide individual-level registry data on inpat...

journal_title：Annals of the rheumatic diseases

authors： Lindhardsen J,Gislason GH,Jacobsen S,Ahlehoff O,Olsen AM,Madsen OR,Torp-Pedersen C,Hansen PR

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:Few studies have addressed the natural course of, or prognostic factors for the salivary and lacrimal function in primary Sjögren syndrome (SS). Except for the early stages, glandular function has been seemingly stable, and SS A antigen (SSA) seropositivity and hypocomplementemia may predict a decline in the...

journal_title：Annals of the rheumatic diseases

authors： Haldorsen K,Moen K,Jacobsen H,Jonsson R,Brun JG

更新日期：2008-07-01 00:00:00

abstract：:Chondromalacia patellae is difficult to diagnosis clinically with accuracy. In order to clarify the relevant symptoms and signs, 78 patients presenting with a clinical diagnosis of chondromalacia were examined by arthroscopy. In 49% of the knees no abnormalities were found. Presenting symptoms were similar in the norm...

journal_title：Annals of the rheumatic diseases

authors： Leslie IJ,Bentley G

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVES:The aorta inhibits paravertebral ossification in diffuse idiopathic skeletal hyperostosis. We investigated if syndesmophytes in ankylosing spondylitis (AS) occurred less often at the vertebral rim near the aorta. METHODS:We performed thoracolumbar CT scans in 60 subjects in this cross-sectional study. The m...

journal_title：Annals of the rheumatic diseases

authors： Tan S,Dasgupta A,Flynn JA,Ward MM

更新日期：2019-07-01 00:00:00

abstract：:Atlanto-axial subluxation occurs with a frequency varying from 6% to 45% in rheumatoid arthritis. Most patients are treated conservatively with a cervical collar. The effectiveness of different cervical collars in inhibiting anterior atlanto-axial subluxation was tested in 11 patients with classical rheumatoid arthrit...

journal_title：Annals of the rheumatic diseases

authors： Althoff B,Goldie IF

更新日期：1980-10-01 00:00:00

abstract：:Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid ar...

journal_title：Annals of the rheumatic diseases

authors： O'Dell JR,Lemley-Gillespie S,Palmer WR,Weaver AL,Moore GF,Klassen LW

更新日期：1991-06-01 00:00:00

abstract：:No consensus has previously been formed regarding the types and presentations of infectious pathogens to be considered as 'opportunistic infections' (OIs) within the setting of biologic therapy. We systematically reviewed published literature reporting OIs in the setting of biologic therapy for inflammatory diseases. ...

journal_title：Annals of the rheumatic diseases

authors： Winthrop KL,Novosad SA,Baddley JW,Calabrese L,Chiller T,Polgreen P,Bartalesi F,Lipman M,Mariette X,Lortholary O,Weinblatt ME,Saag M,Smolen J

更新日期：2015-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterised by chronic inflammation of the joints. Anti-citrullinated protein antibodies (ACPA) are highly specific for RA and are associated with a more severe disease progression. ACPA have also been shown to have a pathological role in RA. In animal models of RA,...

journal_title：Annals of the rheumatic diseases

authors： Suurmond J,Schuerwegh AJ,Toes RE

更新日期：2011-03-01 00:00:00

abstract：:While rheumatoid-factor-producing haemolytic plaque-forming cells (RF--PFC) of the human peripheral blood were easily inhibited by cycloheximide, mouse spleen cells immune to sheep red cells (anti-SRC PFC) were inhibited only after prolonged preincubation in the drug. The RF--PFC were easily inhibited by propranolol, ...

journal_title：Annals of the rheumatic diseases

authors： Moore TL,Rose JE,Vaughan JH

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVE:Hand osteoarthritis is a prevalent disease with limited treatment options. Since joint inflammation is often present, we investigated tumour necrosis factor (TNF) as treatment target in patients with proven joint inflammation in a proof-of-concept study. METHODS:This 1-year, double-blind, randomised, multice...

journal_title：Annals of the rheumatic diseases

authors： Kloppenburg M,Ramonda R,Bobacz K,Kwok WY,Elewaut D,Huizinga TWJ,Kroon FPB,Punzi L,Smolen JS,Vander Cruyssen B,Wolterbeek R,Verbruggen G,Wittoek R

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To compare two plain radiographic methods for sensitivity to detect progression of patellofemoral osteoarthritis. METHODS:Two sets of paired skyline and lateral knee radiographs from 54 hospital referred patients (108 knees) with knee osteoarthritis were taken an average of 31 months apart (range 12-40). Fil...

journal_title：Annals of the rheumatic diseases

authors： Lanyon P,Jones A,Doherty M

更新日期：1996-12-01 00:00:00

abstract：:We have compared the distribution of histocompatibility antigens of 22 Turkish and 14 British patients with Behçet's disease with those of their respective controls. There was a strong association of B5, specifically its Bw51 split, with the disease. A modest increase in the incidence of HLA B27 was noted in British p...

journal_title：Annals of the rheumatic diseases

authors： Yazici H,Chamberlain MA,Schreuder I,D'Amaro J,Muftuoglu M

更新日期：1980-08-01 00:00:00

abstract：:Adult human articular cartilage has been maintained in organ culture for 8 days, and the culture medium, which was changed on alternate days, was pooled. Normal and rheumatoid cartilage was obtained from patients and 4 types of culture were prepared: (1) cartilage alone; (2) cartilage + D-penicillamine; (3) cartilage ...

journal_title：Annals of the rheumatic diseases

authors： Jacoby RK

更新日期：1980-02-01 00:00:00

abstract：:T cell activation and cellular immune responses are modulated by interleukin 2 (IL2) through binding to its corresponding cell surface receptor. Three forms of the receptor are recognised based on IL2 binding affinity. The high affinity receptor is a heterotrimer composed of alpha, beta, and gamma(c)-polypeptide chain...

journal_title：Annals of the rheumatic diseases

authors： Morris JC,Waldmann TA

更新日期：2000-11-01 00:00:00

abstract：:CTLA-4 is a regulator of co-stimulation and inhibits the activation of T cells through interfering with the interaction of CD80/86 on antigen-presenting cells with CD28 on T cells. CTLA-4 binds to the surface of antigen-presenting cells, such as dendritic cells and monocytes through CD80/86. Monocytes can differentiat...

journal_title：Annals of the rheumatic diseases

authors： Axmann R,Herman S,Zaiss M,Franz S,Polzer K,Zwerina J,Herrmann M,Smolen J,Schett G

更新日期：2008-11-01 00:00:00