Neuropsychological effects of long-term opioid use in chronic pain patients.

Abstract:

:Opioids are thought to worsen the performance of psychomotor tasks due to their sedating and mental-clouding effects. As a result, some safety regulations currently restrict the use of opioids when driving or using heavy equipment. We investigated the psychomotor effects of long-term opioid use in 144 patients with low back pain. All subjects were administered two neuropsychological tests (Digit Symbol and Trail Making Test-B) before being prescribed opioids for pain; tests were re-administered at 90- and 180-day intervals. Test scores significantly improved while subjects were taking opioids for pain, which suggests that long-term use of oxycodone with acetaminophen or transdermal fentanyl does not significantly impair cognitive ability or psychomotor function.

journal_name

J Pain Symptom Manage

authors

Jamison RN,Schein JR,Vallow S,Ascher S,Vorsanger GJ,Katz NP

doi

10.1016/s0885-3924(03)00310-5

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

913-21

issue

4

eissn

0885-3924

issn

1873-6513

pii

S0885392403003105

journal_volume

26

pub_type

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