Multiple Rh messenger RNA isoforms are produced by alternative splicing.

abstract：:Cell cycle checkpoints ensure orderly progression of events during cell division. A microtubule damage (MTD)-induced checkpoint has been described in G(1) phase of the cell cycle (G(1)MTC) for which little is known. The present study shows that the G(1)MTC is intact in activated T lymphocytes from mice with the p21(wa...

journal_title：Blood

authors： Mantel CR,Braun SE,Lee Y,Kim YJ,Broxmeyer HE

更新日期：2001-03-01 00:00:00

abstract：:TLRs expressed on dendritic cells (DCs) differentially activate DCs when activated alone or in combination, inducing distinct cytokines and costimulatory molecules that influence T-cell responses. Defining the requirements of DCs to program T cells during priming to become memory rather than effector cells could enhan...

journal_title：Blood

authors： Pufnock JS,Cigal M,Rolczynski LS,Andersen-Nissen E,Wolfl M,McElrath MJ,Greenberg PD

更新日期：2011-06-16 00:00:00

abstract：:Incubation of normal human plasma with dextran sulfate for 7 min at 4 degrees C generates kallikrein amidolytic activity. No kallikrein activity is generated in factor XII or prekallikrein-deficient plasma and only small amounts (8%) in high molecular weight (HMW) kininogen-deficient plasma. Addition of specific antis...

journal_title：Blood

authors： van der Graaf F,Keus FJ,Vlooswijk RA,Bouma BN

更新日期：1982-06-01 00:00:00

abstract：:Despite androgens and intensive supportive care, satisfactory survival in severe aplastic anemia remains at 20% or less. Histocompatible bone marrow transplantation can restore normal hematopoiesis in approximately 40% of similarly severe individuals. Delay of transplantation for 3 wk after diagnosis allows time for p...

journal_title：Blood

authors： Camitta BM,Rappeport JM,Parkman R,Nathan DG

更新日期：1975-03-01 00:00:00

abstract：:High-dose chemoradiotherapy (HDT) with autologous stem cell transplantation (ASCT) is the treatment of choice for patients with relapsed aggressive non-Hodgkin lymphoma (NHL). However, its role in the treatment of patients with primary refractory disease is not well defined. The outcomes of 85 patients with primary re...

journal_title：Blood

authors： Kewalramani T,Zelenetz AD,Hedrick EE,Donnelly GB,Hunte S,Priovolos AC,Qin J,Lyons NC,Yahalom J,Nimer SD,Moskowitz CH

更新日期：2000-10-01 00:00:00

abstract：:We examined the IgM VH gene subgroup use-distribution in serial blood samples of 37 human immunodeficiency virus (HIV)-infected patients and a group of HIV-seronegative healthy adults. The IgM VH gene repertoires of healthy adults were relatively similar to one another and were stable over time. In contrast, individua...

journal_title：Blood

authors： Bessudo A,Rassenti L,Havlir D,Richman D,Feigal E,Kipps TJ

更新日期：1998-08-15 00:00:00

abstract：:Megakaryopoiesis is the hierarchical differentiation of hematopoietic stem cells into megakaryocytes. Differentiating megakaryocytes undergo maturation characterized by endomitosis and produce numerous platelets through proplatelet formation. C-type lectin-like receptor 2 (CLEC-2) is a podoplanin (PDPN) receptor mainl...

journal_title：Blood

authors： Tamura S,Suzuki-Inoue K,Tsukiji N,Shirai T,Sasaki T,Osada M,Satoh K,Ozaki Y

更新日期：2016-03-31 00:00:00

abstract：:Parasitic worms of the genus Schistosoma excrete relatively large amounts of immunogenic glycoproteins (circulating cathodic antigen [CCA]) that contain polysaccharide side chains with the trisaccharide Lewis-x (L(ex)) as a repeating unit. These carbohydrates evoke high titers of specific IgM antibodies that cross-rea...

journal_title：Blood

authors： van Dam GJ,Claas FH,Yazdanbakhsh M,Kruize YC,van Keulen AC,Ferreira ST,Rotmans JP,Deelder AM

更新日期：1996-12-01 00:00:00

abstract：:We previously showed that incorporating target sequences for the hematopoietic-specific microRNA miR-142 into an antigen-encoding transgene prevents antigen expression in antigen-presenting cells (APCs). To determine whether this approach induces immunologic tolerance, we treated mice with a miR-142-regulated lentivir...

journal_title：Blood

authors： Annoni A,Brown BD,Cantore A,Sergi LS,Naldini L,Roncarolo MG

更新日期：2009-12-10 00:00:00

abstract：:Artemisinin resistance threatens worldwide malaria control and elimination. Elevation of phosphatidylinositol-3-phosphate (PI3P) can induce resistance in blood stages of Plasmodium falciparum The parasite unfolded protein response (UPR) has also been implicated as a proteostatic mechanism that may diminish artemisinin...

journal_title：Blood

authors： Bhattacharjee S,Coppens I,Mbengue A,Suresh N,Ghorbal M,Slouka Z,Safeukui I,Tang HY,Speicher DW,Stahelin RV,Mohandas N,Haldar K

更新日期：2018-03-15 00:00:00

abstract：:Somatic mutation in immunoglobulin variable (V) region genes occurs largely in the germinal center and, after neoplastic transformation, imprints V genes of B-cell tumors with the mutational history of the cell of origin. Recently, it has been found that chronic lymphocytic leukemia (CLL) consists of 2 subsets, each w...

journal_title：Blood

authors： Sahota SS,Davis Z,Hamblin TJ,Stevenson FK

更新日期：2000-06-01 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells with the capacity to prime naive T cells for efficient cellular responses against pathogens such as HIV-1. DCs are also susceptible to HIV-1 infection, which may impair their ability to induce immunity. Here, we examined the ability of HIV-1-infected, in vitro-derived...

journal_title：Blood

authors： Smed-Sörensen A,Loré K,Walther-Jallow L,Andersson J,Spetz AL

更新日期：2004-11-01 00:00:00

abstract：:To determine whether the sensitivity of the human long-term culture-initiating cell (LTC-IC) assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for their abilities to influence the number of cells detectable as LTC-IC, to influence LTC-IC maintenance, and/or to influence LTC-IC d...

journal_title：Blood

authors： Hogge DE,Lansdorp PM,Reid D,Gerhard B,Eaves CJ

更新日期：1996-11-15 00:00:00

abstract：:Although the genes for four hematopoietic colony-stimulating factors (CSFs) have been cloned, neither the mechanism of the regulation of their production nor their cellular origins have been established with certainty. Monocytes are known to produce colony-stimulating and burst-promoting activities, as well as several...

journal_title：Blood

authors： Sieff CA,Niemeyer CM,Mentzer SJ,Faller DV

更新日期：1988-10-01 00:00:00

abstract：:It has recently been shown that the Naka antigen, which is absent in 3% to 11% of Japanese blood donors, is expressed on platelet glycoprotein IV (GPIV; CD36) (Tomiyama et al, BLOOD, 75:684, 1990). In the present studies, flow cytometry was used to distinguish differences in the reactivity of Naka+ and Naka- platelets...

journal_title：Blood

authors： Yamamoto N,Ikeda H,Tandon NN,Herman J,Tomiyama Y,Mitani T,Sekiguchi S,Lipsky R,Kralisz U,Jamieson GA

更新日期：1990-11-01 00:00:00

abstract：:Down-regulation of immune responses by regulatory T (Treg) cells is an important mechanism involved in the induction of tolerance to allo-antigens (Ags). Recently, a novel subset of Ag-specific T-cell receptor (TCR)alpha beta+ CD4(-)CD8- (double-negative [DN]) Treg cells has been found to be able to prevent the reject...

journal_title：Blood

authors： Fischer K,Voelkl S,Heymann J,Przybylski GK,Mondal K,Laumer M,Kunz-Schughart L,Schmidt CA,Andreesen R,Mackensen A

更新日期：2005-04-01 00:00:00

abstract：:Although the rheologic behavior of sickle erythrocytes (SS cells) is highly dependent on oxygen tension (pO2) and temperature, very little data exist regarding the effects of deoxygenation and reoxygenation on the rheology of "individual" SS cells at body temperature. We have devised and assessed a new experiment syst...

journal_title：Blood

authors： Itoh T,Chien S,Usami S

更新日期：1992-04-15 00:00:00

abstract：:A hybridoma-derived monoclonal antibody, produced by immunization with the Burkitt's tumor-derived B-lymphoblastoid cell line, B35M, was previously shown to detect a 68,000 dalton surface membrane protein, BL2, on the surface of peripheral blood B cells, which is absent from thymocytes, T cells, and granulocytes. In t...

journal_title：Blood

authors： Knowles DM 2nd,Tolidjian B,Marboe CC,Halper JP,Azzo W,Wang CY

更新日期：1983-07-01 00:00:00

abstract：:Many lineage-specific developmental regulator genes are transcriptionally primed in embryonic stem (ES) cells; RNA Pol(II) is bound at their promoters but is prevented from productive elongation by the activity of polycomb repressive complexes (PRC) 1 and 2. This epigenetically poised state is thought to enable ES cel...

journal_title：Blood

authors： Mazzarella L,Jørgensen HF,Soza-Ried J,Terry AV,Pearson S,Lacaud G,Kouskoff V,Merkenschlager M,Fisher AG

更新日期：2011-01-06 00:00:00

abstract：:Crystallographic structures indicate that gamma-chain residue Asn308 participates in D:D interactions and indeed substitutions of gammaAsn308 with lysine or isoleucine have been identified in dysfibrinogens with impaired polymerization. To probe the role of Asn308 in polymerization, we synthesized 3 variant fibrinogen...

journal_title：Blood

authors： Okumura N,Gorkun OV,Terasawa F,Lord ST

更新日期：2004-06-01 00:00:00

abstract：:We compared the ability of aspirin to suppress platelet aggregation and thromboxane synthesis in ten normal subjects and ten patients with diabetic angiopathy and high rate of entry of new platelets into the circulation. When single doses of 100 to 1,000 mg aspirin were ingested daily for 1 month, there were time gaps...

journal_title：Blood

authors： DiMinno G,Silver MJ,Cerbone AM,Murphy S

更新日期：1986-10-01 00:00:00

abstract：:We report 3 cases of a previously uncharacterized form of histiocytosis presenting in early infancy and showing ALK immunoreactivity. The patients presented with pallor, massive hepatosplenomegaly, anemia, and thrombocytopenia. Liver biopsy showed infiltration of the sinusoids by large histiocytes with markedly folded...

journal_title：Blood

authors： Chan JK,Lamant L,Algar E,Delsol G,Tsang WY,Lee KC,Tiedemann K,Chow CW

更新日期：2008-10-01 00:00:00

abstract：:Extracellular histones have been shown to play an important pathogenic role in many diseases, primarily through their cytotoxicity toward nucleated cells and their ability to promote platelet activation with resultant thrombosis and thrombocytopenia. In contrast, little is known about the effect of extracellular histo...

journal_title：Blood

authors： Kordbacheh F,O'Meara CH,Coupland LA,Lelliott PM,Parish CR

更新日期：2017-12-28 00:00:00

abstract：:Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to de...

journal_title：Blood

authors： Warfvinge R,Geironson L,Sommarin MNE,Lang S,Karlsson C,Roschupkina T,Stenke L,Stentoft J,Olsson-Strömberg U,Hjorth-Hansen H,Mustjoki S,Soneji S,Richter J,Karlsson G

更新日期：2017-04-27 00:00:00

abstract：:A recent clinical trial for adrenoleukodystrophy (ALD) showed the efficacy and safety of lentiviral vector (LV) gene transfer in hematopoietic stem progenitor cells. However, several common insertion sites (CIS) were found in patients' cells, suggesting that LV integrations conferred a selective advantage. We performe...

journal_title：Blood

authors： Biffi A,Bartolomae CC,Cesana D,Cartier N,Aubourg P,Ranzani M,Cesani M,Benedicenti F,Plati T,Rubagotti E,Merella S,Capotondo A,Sgualdino J,Zanetti G,von Kalle C,Schmidt M,Naldini L,Montini E

更新日期：2011-05-19 00:00:00

abstract：:Src activation involves the coordinated regulation of positive and negative tyrosine phosphorylation sites. The mechanism whereby receptor tyrosine kinases, cytokine receptors, and integrins activate Src is not known. Here, we demonstrate that granulocyte colony-stimulating factor (G-CSF) activates Lyn, the predominan...

journal_title：Blood

authors： Futami M,Zhu QS,Whichard ZL,Xia L,Ke Y,Neel BG,Feng GS,Corey SJ

更新日期：2011-07-28 00:00:00

abstract：:The introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has dramatically changed the management of chronic lymphocytic leukemia (CLL). Although responses have been durable in the majority of patients, relapses do occur, especially in the high-risk patient population. Most relapses occur as the result ...

journal_title：Blood

authors： Woyach JA

更新日期：2017-03-09 00:00:00

abstract：:Severe elevation of red blood cell number is often associated with hypertension and thromboembolism resulting in severe cardiovascular complications. However, some individuals such as high altitude dwellers cope well with an increased hematocrit level. We analyzed adaptive mechanisms to excessive erythrocytosis in our...

journal_title：Blood

authors： Vogel J,Kiessling I,Heinicke K,Stallmach T,Ossent P,Vogel O,Aulmann M,Frietsch T,Schmid-Schönbein H,Kuschinsky W,Gassmann M

更新日期：2003-09-15 00:00:00

abstract：:Rap family GTPases consist of multiple members with substantial functional redundancy. With the use of transgenic mice conditionally expressing a bona fide dominant-negative Rap1 mutant, Rap1A17, capable of inhibiting the activation of all Rap family members in B-lineage cells (mb.1-Rap1A17 Tg), we demonstrate that th...

journal_title：Blood

authors： Katayama Y,Sekai M,Hattori M,Miyoshi I,Hamazaki Y,Minato N

更新日期：2009-08-27 00:00:00

abstract：:It is currently debated whether the mechanism of action of therapeutic doses of recombinant factor VIIa (rFVIIa, Novo-Seven) relies on the tissue factor (TF)-independent activity of the enzyme. The present study was conducted to investigate the in vivo hemostatic effects of rFVIIa and 3 analogs thereof with superior i...

journal_title：Blood

authors： Tranholm M,Kristensen K,Kristensen AT,Pyke C,Røjkjaer R,Persson E

更新日期：2003-11-15 00:00:00