Agonist-bound nuclear receptors: not just targets of coactivators.

abstract：:Corticotrophin-releasing hormone (CRH) has been identified in several peripheral tissues, including the female reproductive organs. CRH is expressed in the placenta, myometrium, epithelial endometrium and the endometrial stromal cells at all phases of the menstrual cycle. Similarly, CRH receptors are present in pregna...

journal_title：Journal of molecular endocrinology

authors： Karteris E,Papadopoulou N,Grammatopoulos DK,Hillhouse EW

更新日期：2004-02-01 00:00:00

abstract：:FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays...

journal_title：Journal of molecular endocrinology

authors： Abel MH,Baban D,Lee S,Charlton HM,O'Shaughnessy PJ

更新日期：2009-04-01 00:00:00

abstract：:The interaction of IGF binding protein-2 (IGFBP-2) with IGF-I and -II has been investigated in solution using nuclear magnetic resonance (NMR) spectroscopy. Chemical shift perturbations in 15N- and 2H/15N-labelled IGF-I or -II upon binding to unlabelled thioredoxin-tagged bovine IGFBP-2 (Trx(1-279)IGFBP-2) have been m...

journal_title：Journal of molecular endocrinology

authors： Carrick FE,Hinds MG,McNeil KA,Wallace JC,Forbes BE,Norton RS

更新日期：2005-06-01 00:00:00

abstract：:The p160 coactivators, steroid receptor coactivator-1 (SRC-1), transcriptional intermediary factor-2 (TIF2) and receptor-associated coactivator-3 (RAC3), as well as the coactivator/integrator CBP, mediate estrogen receptor-alpha (ERalpha)-dependent gene expression. Although these coactivators are widely expressed, ERa...

journal_title：Journal of molecular endocrinology

authors： Jaber BM,Mukopadhyay R,Smith CL

更新日期：2004-02-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of fibrate hypolipidaemic drugs and non-genotoxic rodent hepatocarcinogens that are collectively termed peroxisome proliferators. A key marker of peroxisome proliferator action is...

journal_title：Journal of molecular endocrinology

authors： Issemann I,Prince RA,Tugwood JD,Green S

更新日期：1993-08-01 00:00:00

abstract：:Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte function is well established, the role of this protein in other cell types remains unknown. Given that GRAIL is abundant in the liver, we investigated the pote...

journal_title：Journal of molecular endocrinology

authors： Nakamichi S,Senga Y,Inoue H,Emi A,Matsuki Y,Watanabe E,Hiramatsu R,Ogawa W,Kasuga M

更新日期：2009-02-01 00:00:00

abstract：:Type 2 diabetes is characterized by islet dysfunction resulting in hyperglycemia, which can then lead to further deterioration in islet function. A possible mechanism for hyperglycemia-induced islet dysfunction is the accumulation of advanced glycation end products (AGE). The DBA/2 mouse develops pancreatic islet dysf...

journal_title：Journal of molecular endocrinology

authors： Kooptiwut S,Kebede M,Zraika S,Visinoni S,Aston-Mourney K,Favaloro J,Tikellis C,Thomas MC,Forbes JM,Cooper ME,Dunlop M,Proietto J,Andrikopoulos S

更新日期：2005-08-01 00:00:00

abstract：:Screening by differential display of oestrogen-sensitive MCF7 human breast cancer cells grown in the short-term (6 days) and long-term (70 weeks) absence of oestrogen has led to the identification of a new oestrogen-regulated mRNA. The cDNA isolated by differential display has 100% homology from nucleotides 615 to 859...

journal_title：Journal of molecular endocrinology

authors： Stephen R,Corcoran D,Darbre PD

更新日期：1998-06-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. How...

journal_title：Journal of molecular endocrinology

authors： Cerrato A,De Falco V,Santoro M

更新日期：2009-10-01 00:00:00

abstract：:Abnormal placental function is well-established as a major cause for poor pregnancy outcome. Placental blood flow within the maternal uteroplacental compartment, the fetoplacental circulation or both is a vital factor in mediating placental function. Impairment in flow in either or both vasculatures is a significant r...

journal_title：Journal of molecular endocrinology

authors： Li Y,Lorca RA,Su EJ

更新日期：2018-01-01 00:00:00

abstract：:The GnRH receptor (GnRHR) is expressed in several non-pituitary tissues, notably in gonads. However, mechanisms underlying the gonad-specific expression of Gnrhr are not well understood. Here, Gnrhr expression was analysed in the developing testes and pituitaries of rats and transgenic mice bearing the human placental...

journal_title：Journal of molecular endocrinology

authors： Ishaq M,Schang AL,Magre S,Laverrière JN,Guillou A,Coudouel N,Wargnier R,Cohen-Tannoudji J,Counis R

更新日期：2013-04-23 00:00:00

abstract：:Both 17beta-estradiol and prolactin play important roles in the mammary gland, raising the possibility of functional cross-talk between the two signaling pathways. Here, we demonstrate that estrogen receptor-alpha (ERalpha) and -beta (ERbeta) are both able to potentiate transcription from a Stat5-responsive promoter w...

journal_title：Journal of molecular endocrinology

authors： Björnström L,Kilic E,Norman M,Parker MG,Sjöberg M

更新日期：2001-08-01 00:00:00

abstract：:The nona-peptide oxytocin (OT) induces contraction of the myometrium by interaction with specific plasma membrane associated OT receptors (OTR), whereas stimulation of beta2-adrenoceptors (beta2AR) causes relaxation. Homologous desensitization of the myometrium to both hormones has been described. However, a possible ...

journal_title：Journal of molecular endocrinology

authors： Engstrøm T,Bratholm P,Vilhardt H,Christensen NJ

更新日期：1998-04-01 00:00:00

abstract：:In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism, a mutagenesis screen after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. One of the generated mouse lines with hyperaldosteronism was phenotypically and geneti...

journal_title：Journal of molecular endocrinology

authors： Perez-Rivas LG,Rhayem Y,Sabrautzki S,Hantel C,Rathkolb B,Hrabě de Angelis M,Reincke M,Beuschlein F,Spyroglou A

更新日期：2017-02-01 00:00:00

abstract：:Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid as the 'hormone of pregnancy'. It was the unique 'pro-gestational' bioactivity of progesterone that enabled eventual purification of this ovarian steroid to crystalline form by Willard Myron Allen in the early 1930s. While a fun...

journal_title：Journal of molecular endocrinology

authors： DeMayo FJ,Lydon JP

更新日期：2020-07-01 00:00:00

abstract：:In non-mammalian vertebrates, estrogens are key players in ovarian differentiation, but the mechanisms by which they act remain poorly understood. The present study on rainbow trout was designed to investigate whether estrogens trigger the female pathway by activating a group of early female genes (i.e. cyp19a1, foxl2...

journal_title：Journal of molecular endocrinology

authors： Vizziano-Cantonnet D,Baron D,Mahè S,Cauty C,Fostier A,Guiguen Y

更新日期：2008-11-01 00:00:00

abstract：:Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...

journal_title：Journal of molecular endocrinology

authors： Ackermann AM,Gannon M

更新日期：2007-02-01 00:00:00

abstract：:In contrast to the classical model describing the synthesis of androgens and estrogens as restricted to somatic cells, a previous study demonstrated that Xenopus laevis oocytes participate in androgen synthesis. The objective of our study was to determine whether Xenopus oocytes are also involved in estrogen synthesis...

journal_title：Journal of molecular endocrinology

authors： Gohin M,Bodinier P,Fostier A,Bobe J,Chesnel F

更新日期：2011-09-07 00:00:00

abstract：:Intracellular glucocorticoid (GC) receptor (GR) function determines tissue sensitivity to GCs and strongly affects the development of type 2 diabetes and obesity. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mediates intracellular steroid exposure to mouse liver GR by prereceptor reactivation of GCs and is...

journal_title：Journal of molecular endocrinology

authors： Liu Y,Nakagawa Y,Wang Y,Liu L,Du H,Wang W,Ren X,Lutfy K,Friedman TC

更新日期：2008-08-01 00:00:00

abstract：:In vertebrates, sex is determined essentially by two means, genetic factors located on sex chromosomes and epigenetic factors such as temperature experienced by the individual during development. Steroids, especially estrogens, are clearly involved in gonadal differentiation in non-mammalian vertebrates. In this regar...

journal_title：Journal of molecular endocrinology

authors： Kuntz S,Chesnel A,Flament S,Chardard D

更新日期：2004-12-01 00:00:00

abstract：:Transportation of vitamin C [also called ascorbic acid (AA)], an important water-soluble antioxidant and cofactor in testis, requires glucose transporter family (GLUTs) and sodium/vitamin C cotransporter family (SVCT1 and SVCT2). There is so far scant information vis-à-vis the functional roles of SVCTs in testis, alth...

journal_title：Journal of molecular endocrinology

authors： Gao G,Zhao Y,Wang K,Wang F

更新日期：2020-12-01 00:00:00

abstract：:The mouse knockout of the estrogen receptor alpha (ERalpha) gene, known as alphaERKO, has been extensively used for several years to study the role and function of ERalpha. Residual estradiol binding capacity in uterine tissue of 5-10% raised doubts if this knockout is a genuine null mutation of ERalpha. Although alte...

journal_title：Journal of molecular endocrinology

authors： Kos M,Denger S,Reid G,Korach KS,Gannon F

更新日期：2002-12-01 00:00:00

abstract：:High energy intake and, specifically, high dietary fat intake challenge the mammalian metabolism and correlate with many metabolic disorders such as obesity and diabetes. However, dietary restriction (DR) is known to prevent the development of metabolic disorders. The current western diets are highly enriched in fat, ...

journal_title：Journal of molecular endocrinology

authors： Duivenvoorde LP,van Schothorst EM,Bunschoten A,Keijer J

更新日期：2011-08-01 00:00:00

abstract：:Seven bovine follistatin (FS) cDNA clones were isolated from a bovine ovarian follicle cDNA library. The predicted amino acid sequences revealed that six of the cDNA clones represented an FS precursor of 344 amino acids which corresponded to a mature FS of 315 amino acids (FS 315), with one cDNA clone containing the e...

journal_title：Journal of molecular endocrinology

authors： Saleh M,Garcia S,Mercer JE,Findlay JK

更新日期：1994-12-01 00:00:00

abstract：:Fatty acids are essential nutrients that contribute to several intracellular functions. Fatty acid synthesis and oxidation are known to be regulated by sterol regulatory element-binding proteins (SREBPs), which play a pivotal role in the regulation of cellular triglyceride synthesis and cholesterol biogenesis. Recent ...

journal_title：Journal of molecular endocrinology

authors： Park HY,Kang HS,Im SS

更新日期：2018-10-01 00:00:00

abstract：:Endometriosis is an incurable hormone-dependent inflammatory disease that causes chronic pelvic pain and infertility characterized by implantation and growth of endometrial tissue outside the uterine cavity. Symptoms have a major impact on the quality of life of patients resulting in socioeconomic, physical and psycho...

journal_title：Journal of molecular endocrinology

authors： Piccinato CA,Malvezzi H,Gibson DA,Saunders PTK

更新日期：2018-08-01 00:00:00

abstract：:Sucrose density gradient purified plasma membranes isolated from brown adipose tissue of cold-acclimated hamsters (4-10 weeks at 0-4 degreesC) were analysed for the content of the short (GsalphaS) and long (GsalphaL) variants of Gsalpha protein (the alpha subunit of the stimulatory G protein) and compared with the mem...

journal_title：Journal of molecular endocrinology

authors： Bourová L,Novotn J,Svoboda P

更新日期：1999-02-01 00:00:00

abstract：:Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downst...

journal_title：Journal of molecular endocrinology

authors： Folch J,Pedrós I,Patraca I,Sureda F,Junyent F,Beas-Zarate C,Verdaguer E,Pallàs M,Auladell C,Camins A

更新日期：2012-10-10 00:00:00

abstract：:It has recently been shown that 20 kDa human growth hormone (hGH) forms the 1:2 hGH:hGH receptor (hGHR) complex and expresses full agonistic activity, although it hardly forms the 1:1 GH:GHR complex as compared with 22 kDa hGH. To clarify this mechanism, we analyzed the mode of receptor dimerization of 20 kDa hGH usin...

journal_title：Journal of molecular endocrinology

authors： Uchida H,Banba S,Wada M,Matsumoto K,Ikeda M,Naito N,Tanaka E,Honjo M

更新日期：1999-12-01 00:00:00

abstract：:The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, and memory. The zebrafish has been proposed as a candidate to study the in vivo effects of several drugs of abuse and to discover new pharmacolog...

journal_title：Journal of molecular endocrinology

authors： Rivas-Boyero AA,Herrero-Turrión MJ,Gonzalez-Nunez V,Sánchez-Simón FM,Barreto-Valer K,Rodríguez RE

更新日期：2011-03-03 00:00:00