Dual functionality of cyclooxygenase-2 as a regulator of tumor necrosis factor-mediated G1 shortening and nitric oxide-mediated inhibition of vascular smooth muscle cell proliferation.

abstract：BACKGROUND:Since 1990, sternotomy has been the preferred approach for construction of a modified Blalock-Taussig shunt (MBTS) at Children's Hospital, Boston, Mass. In retrospect, we sought to test the hypothesis that this approach yields less mortality and morbidity than the traditional thoracotomy approach. METHODS A...

journal_title：Circulation

authors： Odim J,Portzky M,Zurakowski D,Wernovsky G,Burke RP,Mayer JE Jr,Castaneda AR,Jonas RA

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemic mice lacking factors required for activation of CD4+ T cells are characterized by reduced development of atherosclerosis. Consequently, it has been assumed that atherosclerosis involves loss of tolerance against modified self-antigens generated in response to hypercholesterolemia and tha...

journal_title：Circulation

authors： Wigren M,Rattik S,Yao Mattisson I,Tomas L,Grönberg C,Söderberg I,Alm R,Sundius L,Ljungcrantz I,Björkbacka H,Fredrikson GN,Nilsson J

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:Cardiac mechanical restitution and relaxation restitution are thought to be physiological correlates of the recovery kinetics of Ca2+ release mechanisms and sequestration capacity of the sarcoplasmic reticulum (SR). Since congestive heart failure is characterized by abnormal intracellular Ca2+ handling, we s...

journal_title：Circulation

authors： Prabhu SD,Freeman GL

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore co...

journal_title：Circulation

authors： Medley TL,Cole TJ,Gatzka CD,Wang WY,Dart AM,Kingwell BA

更新日期：2002-02-19 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...

journal_title：Circulation

authors： Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

更新日期：1999-04-06 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：:In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (...

journal_title：Circulation

authors： Nakazawa M,Nakanishi T,Okuda H,Satomi G,Nakae S,Imai Y,Takao A

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:The pulmonary autograft procedure (Ross) is now considered the gold standard for aortic valve replacement. One of its advantages is the freedom from macroemboli without anticoagulation. Whether this holds true for circulating microemboli, detectable as high-intensity transient Doppler signals (HITS), has not...

journal_title：Circulation

authors： Nötzold A,Droste DW,Hagedorn G,Berndt S,Kaps M,Graf B,Sievers HH

更新日期：1997-09-16 00:00:00

abstract：BACKGROUND:The aim of the study was to establish the influence of proximal coronary artery atheroma and smoking habit on the stimulated release of tissue plasminogen activator (tPA) from the heart. METHODS AND RESULTS:After diagnostic coronary angiography in 25 patients, the left anterior descending coronary artery (L...

journal_title：Circulation

authors： Newby DE,McLeod AL,Uren NG,Flint L,Ludlam CA,Webb DJ,Fox KA,Boon NA

更新日期：2001-04-17 00:00:00

abstract：:Various electrocardiographic and vectorcardiographic (ECG-VCG) patterns of ventricular conduction disturbances are inducible by premature right atrial stimulation (PRAS). These patterns are a consequence of different degrees of refractoriness in the specialized ventricular conduction system. We observed that the inter...

journal_title：Circulation

authors： Piccolo E,Raviele A,Delise P,Dainese F,Pascotto P,Totaro G,Sartori F,D'Este D

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:We recently reported that arterial superoxide (O2-) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low renin hypertension. Tetrahydrobiopterin (BH4), a potent reducing molecule with antioxidant properties and an essential cofactor for endothe...

journal_title：Circulation

authors： Zheng JS,Yang XQ,Lookingland KJ,Fink GD,Hesslinger C,Kapatos G,Kovesdi I,Chen AF

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Cardiac tamponade is associated with fatal outcomes for patients with acute type A aortic dissection, and the presence of cardiac tamponade should prompt urgent aortic repair. However, treatment of the patient with critical cardiac tamponade who cannot survive until surgery remains unclear. We analyzed our e...

journal_title：Circulation

authors： Hayashi T,Tsukube T,Yamashita T,Haraguchi T,Matsukawa R,Kozawa S,Ogawa K,Okita Y

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:While previous clinical studies have shown a possible beneficial effect of the reperfusion performed at a relatively late phase of acute myocardial infarction ("late reperfusion") in preventing left ventricular enlargement, the mechanism has not been clarified. METHODS AND RESULTS:Of 89 patients with an ini...

journal_title：Circulation

authors： Hirayama A,Adachi T,Asada S,Mishima M,Nanto S,Kusuoka H,Yamamoto K,Matsumura Y,Hori M,Inoue M

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF. METH...

journal_title：Circulation

authors： Narkiewicz K,Pesek CA,van de Borne PJ,Kato M,Somers VK

更新日期：1999-07-20 00:00:00

abstract：BACKGROUND:NAD(P)H oxidases are important sources of superoxide in the vasculature, the activity of which is associated with risk factors for human atherosclerosis. This study was designed to investigate the localization of superoxide production and the expression of the Nox family of NAD(P)H oxidase proteins (gp91phox...

journal_title：Circulation

authors： Sorescu D,Weiss D,Lassègue B,Clempus RE,Szöcs K,Sorescu GP,Valppu L,Quinn MT,Lambeth JD,Vega JD,Taylor WR,Griendling KK

更新日期：2002-03-26 00:00:00

abstract：:The evidence supporting the thesis that hypertension can be prevented by eliminating salt from the diet is based on four principal sources: (1) epidemiological studies in unacculturated peoples showing that the prevalence of hypertension is inversely correlated with the degree of salt intake; (2) hemodynamic studies s...

journal_title：Circulation

authors： Freis ED

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:The positions, sizes, and shapes of ventricular septal defects (VSDs) can be difficult to assess by 2-dimensional echocardiography (2DE). Volume-rendered 3-dimensional echocardiography (3DE) can provide unique views of VSDs from the left ventricular (LV) side, allowing complete assessment of their circumfere...

journal_title：Circulation

authors： Kardon RE,Cao QL,Masani N,Sugeng L,Supran S,Warner KG,Pandian NG,Marx GR

更新日期：1998-09-29 00:00:00

abstract：BACKGROUND:An estimated 275,000 patients undergo heart valve replacement each year. However, existing solutions for valve replacement are complicated by the morbidity associated with lifelong anticoagulation of mechanical valves and the limited durability of bioprostheses. Recent advances in tissue engineering and our ...

journal_title：Circulation

authors： Sutherland FW,Perry TE,Yu Y,Sherwood MC,Rabkin E,Masuda Y,Garcia GA,McLellan DL,Engelmayr GC Jr,Sacks MS,Schoen FJ,Mayer JE Jr

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural dispersion of repolarization (TDR), and torsade de pointes (TdP) induced by beta-adrenergic agonists under conditions mimicking the LQT1 form of the congenital long-QT syndrome. METHODS AND RESU...

journal_title：Circulation

authors： Shimizu W,Antzelevitch C

更新日期：1998-11-24 00:00:00

abstract：BACKGROUND:Q waves on a 12-lead ECG are markers of a prior myocardial infarction (MI). However, they may regress or even disappear over time, and there is no specific ECG sign of a non-Q-wave MI. Fragmented QRS complexes (fQRSs), which include various RSR' patterns, without a typical bundle-branch block are markers of ...

journal_title：Circulation

authors： Das MK,Khan B,Jacob S,Kumar A,Mahenthiran J

更新日期：2006-05-30 00:00:00

abstract：:Despite a 2% to 3% prevalence of echocardiographically defined mitral valve prolapse (MVP) in the general population, the actual burden, risk stratification, and treatment of the so-called arrhythmic MVP are unknown. The clinical profile is characterized by a patient, usually female, with mostly bileaflet myxomatous d...

journal_title：Circulation

authors： Basso C,Iliceto S,Thiene G,Perazzolo Marra M

更新日期：2019-09-10 00:00:00

abstract：:Neutrophil activation and infiltration into the ischemic myocardium after reperfusion may limit the amount of salvageable myocardium (reperfusion injury). The effects of intravenous perfluorochemicals (Fluosol-DA) on infarct size, ventricular contractility, and neutrophil function were assessed in an occlusion-reperfu...

journal_title：Circulation

authors： Bajaj AK,Cobb MA,Virmani R,Gay JC,Light RT,Forman MB

更新日期：1989-03-01 00:00:00

abstract：:From November 1981 to November 1982, intra-aortic balloon pumping (IABP) was used after surgery in eight patients who were from 6 weeks to 6 years old and who weighed from 4.2 to 16.2 kg. In seven patients, specially constructed intra-aortic balloons with 2.5 and 5.0 ml volumes mounted on No. 5F catheters were used. I...

journal_title：Circulation

authors： Veasy LG,Blalock RC,Orth JL,Boucek MM

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...

journal_title：Circulation

authors： Tobis JM,Mallery J,Mahon D,Lehmann K,Zalesky P,Griffith J,Gessert J,Moriuchi M,McRae M,Dwyer ML

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Epidemiological studies aimed at correlating coronary heart disease (CHD) with serum ferritin levels have thus far yielded inconsistent results. We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might...

journal_title：Circulation

authors： van der A DL,Marx JJ,Grobbee DE,Kamphuis MH,Georgiou NA,van Kats-Renaud JH,Breuer W,Cabantchik ZI,Roest M,Voorbij HA,van der Schouw YT

更新日期：2006-04-25 00:00:00

abstract：BACKGROUND:The effects of cardiac transplantation on cognitive brain function are uncertain. METHODS AND RESULTS:We measured cognitive brain function and quality of life in out-of-hospital cardiac transplant candidates (n = 55; ejection fraction, 19.9%; age, 54.8 years [means]). After transplantation, the patients wer...

journal_title：Circulation

authors： Grimm M,Yeganehfar W,Laufer G,Madl C,Kramer L,Eisenhuber E,Simon P,Kupilik N,Schreiner W,Pacher R,Bunzel B,Wolner E,Grimm G

更新日期：1996-09-15 00:00:00

abstract：:Thirteen male patients with NYHA class IV congestive heart failure refractory to conventional therapy were treated with oral fenoximone, a new imidazole compound with inotropic and vasodilator effects, for a mean duration of 11 weeks (range 2 to 34). On initial hemodynamic evaluation, the effects of oral fenoximone we...

journal_title：Circulation

authors： Shah PK,Amin DK,Hulse S,Shellock F,Swan HJ

更新日期：1985-02-01 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with preexisting cardiovascular disease, hypertension, and related conditions incur disproportionately worse outcome. The high infectivity of severe a...

journal_title：Circulation

authors： Liu PP,Blet A,Smyth D,Li H

更新日期：2020-07-07 00:00:00

abstract：:Although exercise ECG testing has been shown to have important prognostic value after acute myocardial infarction, exercise 201Tl scintigraphy offers several potential advantages, including: 1) increased sensitivity for detecting residual myocardial ischemia; 2) the ability to localize ischemia to a specific area or a...

journal_title：Circulation

authors： Gibson RS,Watson DD

更新日期：1991-09-01 00:00:00

abstract：:Electrophysiologic effects of 50 mg iv ajmaline were evaluated in 10 patients with atrioventricular nodal reentrant paroxysmal supraventricular tachycardia (PSVT) utilizing the slow pathway for antegrade and the fast pathway for retrograde conduction. Ajmaline terminated the PSVT in all 10 patients in 17 to 165 sec (m...

journal_title：Circulation

authors： Sethi KK,Jaishankar S,Gupta MP

更新日期：1984-11-01 00:00:00