Tumor load in patients with follicular lymphoma post stem cell transplantation may correlate with clinical course.

Abstract:

:The purpose of this study was to evaluate if the tumor load, as determined by a real-time quantitative PCR (RQ-PCR) assay, correlated with the clinical course of follicular lymphoma patients after stem cell transplantation (SCT). Cryopreserved bone marrow and/or peripheral blood samples obtained at different time intervals after SCT from 11 patients (seven allogeneic, T-cell depleted/four autologous) were tested for tumor load, as defined by t(14;18) positive cells/total cells, using RQ-PCR. None of the six patients who remained in remission had samples with a tumor load >0.01% after SCT, although fluctuating tumor loads of 0.01% after SCT (0/6 vs 4/5, P<0.02, Fisher's exact). Our results suggest that RQ-PCR measurable tumor load >0.01% after SCT may correlate with relapsed/progressive disease. Prospective studies with greater numbers of cases are indicated to better determine the critical tumor load that predicts poor outcome after SCT with RQ-PCR.

journal_name

Bone Marrow Transplant

authors

Chang CC,Bredeson C,Juckett M,Logan B,Keever-Taylor CA

doi

10.1038/sj.bmt.1704130

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

287-91

issue

3

eissn

0268-3369

issn

1476-5365

pii

1704130

journal_volume

32

pub_type

杂志文章
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