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Prolonged remission of longstanding systemic lupus erythematosus after autologous bone marrow transplant for non-Hodgkin's lymphoma.

Abstract：

:We describe a patient with longstanding steroid-dependent systemic lupus erythematosus (SLE) in whom clinical and serological remission was achieved following high-dose therapy and autologous bone marrow rescue for high-grade non-Hodgkin's lymphoma. However, 3 years later, autoimmune disease re-presented in the form of immune thrombocytopenia (ITP), which had not previously been a feature of the SLE, necessitating reintroduction of steroid immunosuppression. Relapse of SLE is most likely, although de novo ITP post-BMT is also a possibility. The case suggests that severe long-standing autoimmune disease may be controlled by high-dose therapy and autologous stem cell reconstitution. However, further studies are required to determine the mechanism of re-emergence of autoimmunity and to evaluate optimal regimens and the potential value of such therapy in severe autoimmune diseases.

journal_name

Bone Marrow Transplant

journal_title

Bone marrow transplantation

authors

Snowden JA,Patton WN,O'Donnell JL,Hannah EE,Hart DN

doi

10.1038/sj.bmt.1700815

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

1247-50

issue

12

eissn

0268-3369

issn

1476-5365

journal_volume

19

pub_type

杂志文章

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