A study of once-daily amikacin with low peak target concentrations in intensive care unit patients: pharmacokinetics and associated outcomes.


PURPOSE:The aim of this study was to assess the pharmacokinetics of individualized amikacin single-dosage regimens targeting low peak serum concentrations in a population of intensive care unit (ICU) patients, and to describe the outcomes associated with this dosing strategy. MATERIALS AND METHODS:In this prospective, noncomparative, pharmacokinetic study, 36 ICU patients with adequate renal function were treated with amikacin (intravenous infusion), in combination with other antibiotics, for hospital-acquired infections. The initial doses of amikacin were calculated based on individual creatinine clearance values whereas subsequent doses were calculated by using the amikacin pharmacokinetic parameters estimated from the serum concentration-time data of each individual patient (samples were drawn postinfusion, 1 h, 3 h, 6 h, and 10 h after the onset of the infusion and just before the next dose on days 2, 4, and 7 of therapy). RESULTS:Results showed moderate only interpatient and lack of intrapatient (except for the volume of distribution) variability in amikacin pharmacokinetic parameters. There were no significant differences between achieved and target peak levels. Clinical response was noted in 94% and bacteriologic response was noted in 86% of patients. Nephrotoxicity did not occur during or after treatment. CONCLUSIONS:Amikacin dosage individualization with low peak target concentrations was successful for the 36 ICU patients. This dosing strategy was not associated with nephrotoxicity, but conclusions on clinical efficacy cannot be drawn from this limited study.


J Crit Care


Journal of critical care


Bacopoulou F,Markantonis SL,Pavlou E,Adamidou M




Has Abstract


2003-06-01 00:00:00














  • The reliability and validity of passive leg raise and fluid bolus to assess fluid responsiveness in spontaneously breathing emergency department patients.

    abstract:PURPOSE:We investigated the reproducibility of passive leg raise (PLR) and fluid bolus (BOLUS) using the Non-Invasive Cardiac Output Monitor (NICOM; Cheetah Medical, Tel Aviv, Israel) for assessment of fluid responsiveness (FR) in spontaneously breathing emergency department (ED) patients. METHODS:Prospective, observa...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Duus N,Shogilev DJ,Skibsted S,Zijlstra HW,Fish E,Oren-Grinberg A,Lior Y,Novack V,Talmor D,Kirkegaard H,Shapiro NI

    更新日期:2015-02-01 00:00:00

  • Improving the 2007 Infectious Disease Society of America/American Thoracic Society severe community-acquired pneumonia criteria to predict intensive care unit admission.

    abstract:PURPOSE:To improve 2007 Infectious Disease Society of America/American Thoracic Society (IDSA/ATS) severity criteria to predict intensive care unit (ICU) admission in patients hospitalized with pneumonia. METHODS:A composite score that included the 2007 IDSA/ATS criteria for severe pneumonia and additional significant...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Sibila O,Meduri GU,Mortensen EM,Anzueto A,Laserna E,Fernandez JF,El-Sohl A,Restrepo MI

    更新日期:2013-06-01 00:00:00

  • Distribution and determinants of critical illness among status Aboriginal Canadians. A population-based assessment.

    abstract:PURPOSE:The aim of the study is to determine the incidence, demographic risk factors, and outcomes of critical illness among all adult status Aboriginal Canadians (SACs) admitted to intensive care units (ICUs). PATIENTS AND METHODS:A population-based cohort was conducted among adult residents of the Calgary Health Reg...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Laupland KB,Karmali S,Kirkpatrick AW,Crowshoe L,Hameed SM

    更新日期:2006-09-01 00:00:00

  • Comparison between ultrasound- and bronchoscopy-guided percutaneous dilational tracheostomy in critically ill patients: a retrospective cohort study.

    abstract:INTRODUCTION:Percutaneous dilational tracheostomy (PDT) is routinely performed in the intensive care unit with bronchoscopic guidance. Recently, ultrasound (US) has emerged as a new safety adjunct tool to increase the efficacy of PDT. However, the available data are limited to case series without any control group. Hen...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Gobatto AL,Besen BA,Tierno PF,Mendes PV,Cadamuro F,Joelsons D,Melro L,Park M,Malbouisson LM

    更新日期:2015-02-01 00:00:00

  • Development of a fluid resuscitation protocol using inferior vena cava and lung ultrasound.

    abstract::Appropriate fluid resuscitation has been a major focus of critical care medicine since its inception. Currently, the most accurate method to guide fluid administration decisions uses "dynamic" measures that estimate the change in cardiac output that would occur in response to a fluid bolus. Unfortunately, their use re...

    journal_title:Journal of critical care

    pub_type: 杂志文章,评审


    authors: Lee CW,Kory PD,Arntfield RT

    更新日期:2016-02-01 00:00:00

  • Prevalence of acute kidney injury after liver transplantation in children: Comparison of the pRIFLE, AKIN, and KDIGO criteria using corrected serum creatinine.

    abstract:PURPOSE:To compare the application of three standardized definitions of acute kidney injury (AKI), using corrected serum creatinine values, in children immediately after liver transplantation. METHODS:Retrospective search of a tertiary pediatric hospital database yielded 77 patients (age < 18 years) who underwent live...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Nahum E,Kadmon G,Kaplan E,Weissbach A,Hijazi H,Haskin O,Mozer-Glassberg Y

    更新日期:2019-04-01 00:00:00

  • Acute respiratory distress syndrome in leptospirosis.

    abstract:PURPOSE:Acute Respiratory Distress Syndrome is a major complication of leptospirosis, leading to the majority of fatalities. METHODS:Retrospective, descriptive and single-center cohort study. The primary outcome was the Standardized Mortality Ratio (SMR) for ARDS in leptospirosis based on the quartiles of the SAPS2 sc...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Vandroux D,Chanareille P,Delmas B,Gaüzère BA,Allou N,Raffray L,Jaffar-Bandjee MC,Martinet O,Ferdynus C,Jabot J

    更新日期:2019-06-01 00:00:00

  • Pleurodesis using autologous blood: a new concept in the management of persistent air leak in acute respiratory distress syndrome.

    abstract:OBJECTIVE:Pneumothorax is present as a frequent complication in acute respiratory distress syndrome (ARDS). Persistent air leak (PAL) prolongs pneumothorax in 2% of cases of ARDS, increasing the rate of mortality by 26%. Pleurodesis using autologous blood (PAB) is an effective method in cases of oncological pulmonary s...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Martínez-Escobar S,Ruiz-Bailén M,Lorente-Acosta MJ,Vicente-Rull JR,Martínez-Coronel JF,Rodríguez-Cuartero A

    更新日期:2006-06-01 00:00:00

  • Impact of positive fluid balance on critically ill surgical patients: a prospective observational study.

    abstract:PURPOSE:The purpose of this study is to determine the effect of postoperative fluid balance (FB) on subsequent outcomes in acute care surgery (ACS) patients admitted to the surgical intensive care unit (ICU). MATERIAL AND METHODS:Acute care surgery patients admitted to the surgical ICU from 06/2012 to 01/2013 were fol...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Barmparas G,Liou D,Lee D,Fierro N,Bloom M,Ley E,Salim A,Bukur M

    更新日期:2014-12-01 00:00:00

  • Patient-ventilator dyssynchronies: Are they all the same? A clinical classification to guide actions.

    abstract::Patient ventilatory dyssynchrony (PVD) is a mismatch between the respiratory drive of the patient and ventilatory assistance. It is a complex event seen in almost all ventilated patients and at any ventilator mode, with uncertain significance and prognosis. Due to its different pathophysiological mechanisms, there is ...

    journal_title:Journal of critical care

    pub_type: 杂志文章,评审


    authors: Damiani LF,Bruhn A,Retamal J,Bugedo G

    更新日期:2020-12-01 00:00:00

  • Risk factors for prolonged duration of mechanical ventilation in acute traumatic tetraplegic patients--a retrospective cohort study.

    abstract:PURPOSE:Respiratory complications constitute an important determinant of length of stay in tetraplegic patients. In a population of tetraplegic patients, we investigated the factors involved in the duration of mechanical ventilation (MV) and whether the duration of MV was associated with the long-term neurologic status...

    journal_title:Journal of critical care

    pub_type: 杂志文章,多中心研究


    authors: Roquilly A,Seguin P,Mimoz O,Feuillet F,Rosenczweig E,Chevalier F,Loutrel O,Malledant Y,Sebille V,Asehnoune K,ATLANREA Study Group.

    更新日期:2014-04-01 00:00:00

  • Normal saline instillation before endotracheal suctioning: "What does the evidence say? What do the nurses think?": Multimethod study.

    abstract:PURPOSE:This study aimed to systematically review studies that investigated the effects of normal saline instillation before endotracheal suctioning and to determine the views of nurses concerning this procedure. METHODS:This study was carried out in 2 stages as a systematic review and a descriptive study. In the firs...

    journal_title:Journal of critical care

    pub_type: 杂志文章,评审


    authors: Ayhan H,Tastan S,Iyigun E,Akamca Y,Arikan E,Sevim Z

    更新日期:2015-08-01 00:00:00

  • Bedside implantation of a new temporary vena cava inferior filter - Safety and efficacy results of the European ANGEL-Registry.

    abstract:PURPOSE:Pulmonary embolism (PE) is a frequently occurring complication in critically ill patients. Simultaneous occurrence of PE and life-threatening bleeding, may render medical anticoagulation impossible. For these patients, inferior vena cava filters (IVCF) present a valuable therapeutic alternative. The Angel® cath...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Baumann S,Becher T,Giannakopoulos K,Jabbour C,Rutsch M,Fastner C,El-Battrawy I,Ansari U,Lossnitzer D,Behnes M,Alonso A,Kirschning T,Michels G,Stern D,Dissmann R,Kueck O,Taccone FS,Waldmann C,Bunker N,Postiglione M,

    更新日期:2018-04-01 00:00:00

  • Effectiveness of 7.5% hypertonic saline in children with severe traumatic brain injury.

    abstract:PURPOSE:Hyperosmolar therapies aim at controlling increased intracranial pressure (ICP) in patients with traumatic brain injury (TBI). The aim of this study was to evaluate the effect of 7.5% hypertonic saline (HTS) on ICP and cerebral perfusion pressure (CPP) in children with severe TBI. MATERIALS AND METHODS:Medical...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Rallis D,Poulos P,Kazantzi M,Chalkias A,Kalampalikis P

    更新日期:2017-04-01 00:00:00

  • Family satisfaction in the intensive care unit: cross-cultural adaptation of a questionnaire.

    abstract:PURPOSE:Family needs and expectations are often unmet in the intensive care unit (ICU), leading to dissatisfaction. This study assesses cross-cultural adaptability of an instrument evaluating family satisfaction in the ICU. MATERIALS AND METHODS:A Canadian instrument on family satisfaction was adapted for German langu...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Stricker KH,Niemann S,Bugnon S,Wurz J,Rohrer O,Rothen HU

    更新日期:2007-09-01 00:00:00

  • Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury.

    abstract:PURPOSE:Low tidal volume (LTV) ventilation reduces mortality in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This study investigates adherence of intraoperative LTV and whether patient outcomes were different with or without continued intraoperative LTV ventilation in patients wi...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Chaiwat O,Vavilala MS,Philip S,Malakouti A,Neff MJ,Deem S,Treggiari MM,Wang J,Lang JD

    更新日期:2011-04-01 00:00:00

  • Respiratory pathogen colonization of dental plaque, the lower airways, and endotracheal tube biofilms during mechanical ventilation.

    abstract:PURPOSE:In mechanically ventilated patients, the endotracheal tube is an essential interface between the patient and ventilator, but inadvertently, it also facilitates the development of ventilator-associated pneumonia (VAP) by subverting pulmonary host defenses. A number of investigations suggest that bacteria coloniz...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Sands KM,Wilson MJ,Lewis MAO,Wise MP,Palmer N,Hayes AJ,Barnes RA,Williams DW

    更新日期:2017-02-01 00:00:00

  • Serial changes in adiponectin and resistin in critically ill patients with sepsis: associations with sepsis phase, severity, and circulating cytokine levels.

    abstract:PURPOSE:The aim of the present study was to describe the variation in adiponectin and resistin levels, 2 adipokines with opposing effects on metabolism, in mechanically ventilated patients with sepsis and their relationships to disease severity and cytokine levels. MATERIALS AND METHODS:An observational prospective st...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Vassiliadi DA,Tzanela M,Kotanidou A,Orfanos SE,Nikitas N,Armaganidis A,Koutsilieris M,Roussos C,Tsagarakis S,Dimopoulou I

    更新日期:2012-08-01 00:00:00

  • Outcomes comparison in patients admitted to low complexity rural and urban intensive care units in the Veterans Health Administration.

    abstract:PURPOSE:To evaluate mortality, length of stay, and inter-hospital transfer in the Veteran Health Administration (VHA) among low complexity Intensive Care Unit (ICU) patients. MATERIALS AND METHOD:Retrospective study of adult ICU admissions identified in VHA Medical SAS®; 2010-2015 at Veterans Affairs (VA) Medical Cent...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: O'Shea AMJ,Fortis S,Vaughan Sarrazin M,Moeckli J,Yarbrough WC,Schacht Reisinger H

    更新日期:2019-02-01 00:00:00

  • Evidence summary resources may influence clinical decision making: A case-based scenario evaluation of an evidence summary tool.

    abstract:PURPOSE:Evidence summary resources are popular with clinicians but it is unknown whether they can influence clinical decision making. We evaluated whether an extremely condensed and explicit evidence summary tool could influence clinical decision making. MATERIALS AND METHODS:An evidence summary tool was developed usi...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Heighes PT,Doig GS

    更新日期:2020-02-01 00:00:00

  • Heated humidified high-flow nasal cannula oxygen after thoracic surgery - A randomized prospective clinical pilot trial.

    abstract:BACKGROUND:Thoracic surgery patients are at high-risk for adverse pulmonary outcomes. Heated humidified high-flow nasal cannula oxygen (HHFNC O2) may decrease such events. We hypothesized that patients randomized to prophylactic HHFNC O2 would develop fewer pulmonary complications compared to conventional O2 therapy. ...

    journal_title:Journal of critical care

    pub_type: 杂志文章,随机对照试验


    authors: Brainard J,Scott BK,Sullivan BL,Fernandez-Bustamante A,Piccoli JR,Gebbink MG,Bartels K

    更新日期:2017-08-01 00:00:00

  • Predictive value of plasma biomarkers for mortality and organ failure development in patients with acute respiratory distress syndrome.

    abstract:PURPOSE:To evaluate the predictive value of 6 different biomarkers in the development of multiple-organ failure (MOF) and mortality in a contemporary prospective cohort of acute respiratory distress syndrome (ARDS). METHODS:Patients with ARDS admitted to a tertiary referral center during an 8-month period were include...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Cartin-Ceba R,Hubmayr RD,Qin R,Peters S,Determann RM,Schultz MJ,Gajic O

    更新日期:2015-02-01 00:00:00

  • Barbiturate coma for intracranial hypertension: clinical observations.

    abstract:PURPOSE:To determine the neurologic outcome of patients with intracranial hypertension treated with barbiturate-induced coma. MATERIALS AND METHODS:The records of 49 patients who were admitted to a 31-bed medicosurgical intensive care unit over a 5-year period in whom a barbiturate coma was induced to control intracra...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Dereeper E,Berré J,Vandesteene A,Lefranc F,Vincent JL

    更新日期:2002-03-01 00:00:00

  • National registries: Lessons learnt from quality improvement initiatives in intensive care.

    abstract::National clinical quality registries (CQRs) are effective tools for improving the outcomes of patients admitted to the intensive care unit (ICU), and are increasingly important as healthcare needs evolve. A high-quality ICU CQR is built from a foundation of common requirements and challenges. First, performance indica...

    journal_title:Journal of critical care

    pub_type: 杂志文章,评审


    authors: Litton E,Guidet B,de Lange D

    更新日期:2020-12-01 00:00:00

  • Organ-specific therapy in critical illness: interfacing molecular mechanisms with physiological interventions.

    abstract::Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, which, if sustained, induces widespread endothelial damage and MODS. Immunomodulating therapies, at present, have proven ineffective in reducing morbidity and mortality, presumably because of the heterogeneous nature of s...

    journal_title:Journal of critical care

    pub_type: 杂志文章,评审


    authors: Pinsky MR

    更新日期:1996-06-01 00:00:00

  • Gastric intramucosal PCO2 as a quantitative indicator of the degree of acute hemorrhage.

    abstract:PURPOSE:Gastric intramucosal PCO2 (PiCO2) is a marker of splanchnic dysoxia and hypoperfusion that is increasingly used in intensive care medicine. We assessed two methods, saline-balloon tonometry versus continuous capnometric recirculating gas tonometry (CRGT), for detecting changes in PiCO2 in animals subjected to v...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Guzman JA,Kruse JA

    更新日期:1998-06-01 00:00:00

  • Recovery of cough after extubation after coronary artery bypass grafting: A prospective study.

    abstract:PURPOSE:This study aims to evaluate the effect of intubation for coronary artery bypass grafting (CABG) on the cough reflex, an important airway protection mechanism. MATERIALS:Eighty-six participants (70 males) underwent cough reflex texting (CRT) before intubation for CABG to establish baseline threshold for reflexi...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Kallesen M,Psirides A,Huckabee ML

    更新日期:2015-08-01 00:00:00

  • Postintubation hypotension in intensive care unit patients: A multicenter cohort study.

    abstract:PURPOSE:To determine the incidence of postintubation hypotension (PIH) and associated outcomes in critically ill patients requiring endotracheal intubation. MATERIALS AND METHODS:Medical records were reviewed for 479 consecutive critically ill adult patients who required intubation by an intensive care unit (ICU) serv...

    journal_title:Journal of critical care

    pub_type: 杂志文章,多中心研究


    authors: Green RS,Turgeon AF,McIntyre LA,Fox-Robichaud AE,Fergusson DA,Doucette S,Butler MB,Erdogan M,Canadian Critical Care Trials Group (CCCTG).

    更新日期:2015-10-01 00:00:00

  • Postreperfusion syndrome: hypotension after reperfusion of the transplanted liver.

    abstract::Sixty-nine patients undergoing liver transplantation were evaluated to elucidate the relationship between hypotension and physiological changes seen on reperfusion of the grafted liver. Measured variables included hemodynamic profiles, core temperature, serum potassium, ionized calcium levels, arterial blood-gas tensi...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Aggarwal S,Kang Y,Freeman JA,Fortunato FL Jr,Pinsky MR

    更新日期:1993-09-01 00:00:00

  • Indocyanine green clearance as an outcome prediction tool in cardiac surgery: a prospective study.

    abstract:PURPOSE:To evaluate the role of plasma disappearance rate of indocyanine green (PDR-ICG) as an outcome prediction tool in cardiac surgery. PATIENTS AND METHODS:One hundred ninety patients undergoing coronary artery bypass grafting, valve surgery or combined procedures were enrolled. PDR-ICG measurements along with sta...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Weis F,Kilger E,Beiras-Fernandez A,Hinske CL,Nassau K,Adnan L,Vicol C,Kur F,Möhnle P

    更新日期:2014-04-01 00:00:00