Abstract：
PURPOSE:To investigate the relationship between idiopathic nonarteritic ischemic optic neuropathy (NAION) and serum lipid levels in patients /= 240 mg/dl) with NAION was 3.3 (95% confidence interval, 1.4-7.8), and the likelihood increased when the comparison was restricted to nondiabetic patients. Diabetes mellitus was more common in cases than controls (P = 0.027), but systemic hypertension was not significantly different (P = 0.63). No patient (0 of 24) had a magnetic resonance imaging study consistent with optic neuritis or central nervous system demyelination. Visual improvement was uncommon. CONCLUSIONS:This study demonstrates that hypercholesterolemia is associated with NAION in younger patients. NAION may be the first manifestation of a lipid disorder, a previously unrecognized syndrome. These patients have experienced a focal, microvascular central nervous system ischemic event at a relatively young age. Aggressive treatment of lipid abnormalities in these patients may be warranted.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Deramo VA,Sergott RC,Augsburger JJ,Foroozan R,Savino PJ,Leone Adoi
10.1016/S0161-6420(03)00079-4subject
Has Abstractpub_date
2003-05-01 00:00:00pages
1041-6; discussion 1046issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(03)00079-4journal_volume
110pub_type
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