Abstract:
BACKGROUND:Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF).
METHODS AND RESULTS:For the derivation study, 112 patients with CHF (age 59+/-12 years, peak oxygen consumption [Vo2] 17+/-7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between MFH score and the decision to list patients for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 micromol/L (9.50 mg/dL) (independently of age, peak Vo2, left ventricular ejection fraction, diuretic dose, sodium, creatinine, and urea; P<0.0001). In the validation study, UA >or=565 micromol/L predicted mortality (hazard ratio, 7.14; P<0.0001). In 16 patients (from both studies) with UA >or=565 micromol/L, left ventricular ejection fraction journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
相关文献
CIRCULATION文献大全abstract:BACKGROUND:Atrial fibrillation (AF) is frequently encountered in patients with heart failure (HF) and is also a predictor of morbidity and mortality in this population. Recent experimental studies have shown electrical and structural atrial remodeling with increased fibrosis in animals with HF and have suggested a prev...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000072793.81076.D4
更新日期:2003-06-17 00:00:00
abstract:BACKGROUND:Because of the marked difference in the incidence and severity of cardiovascular diseases between men and premenopausal women, several groups have studied the effect of sex steroids, particularly estrogen, on vascular endothelial prostacyclin (PGI2) release. No previous studies have addressed the effect of e...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.5.2519
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Considerable controversy exists regarding impairment of cardiac function in diabetes mellitus (DM). We investigated the serial changes in left ventricular (LV) histopathology and LV filling dynamics in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which have been established as an animal model of type II D...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.8.899
更新日期:2000-02-29 00:00:00
abstract:BACKGROUND:Higher carotid intimal-medial thickness (IMT) is associated with cardiovascular risk factors and is predictive of coronary artery disease and stroke in older adults. Carotid IMT was measured in young and middle-aged adults to determine its relationship with risk factors measured (1) in childhood, (2) current...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc4601.099486
更新日期:2001-12-04 00:00:00
abstract::To define the mechanisms of unexpected cardiac arrest in advanced heart failure, we reviewed the causes of cardiac arrest as established from electrocardiographic monitoring and from clinical and autopsy data in patients hospitalized for cardiac transplantation evaluation and management of advanced heart failure (mean...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.6.1675
更新日期:1989-12-01 00:00:00
abstract::Ten subjects with normal hemodynamics were studied during elective cardiac catheterization with right and left heart multisensor micromanometry to assess hemodynamic responses to the Mueller maneuver. Simultaneous right and left circulatory hemodynamics and left ventricular, pulmonary arterial, and aortic pressures we...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.5.1020
更新日期:1987-11-01 00:00:00
abstract::Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.1.56
更新日期:1978-07-01 00:00:00
abstract::The relation between ventricular dysrhythmia during the first 20 hours after hospitalization for acute myocardial infarction and enzymatically estimated infarct size was studied prospectively. The duration of dyshythmia was measured by the total time during which the average premature ventricular depolarization (PVC) ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Aortic valve-preserving procedures have resulted in excellent outcomes in selected patients, particularly those with normal aortic valve leaflets and dilated aortic roots. However, several congenital heart lesions are associated with abnormal aortic valve leaflets. The long-term results of aortic valve repai...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.suppl_3.iii-40
更新日期:2000-11-07 00:00:00
abstract:BACKGROUND:Patients with a non-ST-elevation acute coronary syndrome and prior CABG are at high risk of a recurrent ischemic event despite aspirin therapy. This trial investigated the potential benefit of secondary prevention with warfarin. METHODS AND RESULTS:In a double-blind randomized trial, 135 patients with unsta...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.103.25.3069
更新日期:2001-06-26 00:00:00
abstract:BACKGROUND:Vascular Ehlers-Danlos syndrome (vEDS), also known as EDS type IV, an inherited disorder of connective tissue, results from mutations in the gene encoding type III procollagen (COL3A1). Affected patients are at risk for arterial dissection or rupture, the main cause of death. To understand the pathogenesis o...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000121741.50315.C2
更新日期:2004-03-30 00:00:00
abstract::To evaluate possible occult myocardial disease in 18 patients whose only major manifestation of heart disease was spontaneous ventricular tachycardia or fibrillation, right ventricular endomyocardial biopsies were performed. None of the patients had symptoms of ischemic or congestive heart disease, and at catheterizat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.6.1171
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the adult heart experimentally. Moreover, whether these Ca(2+) release channels are present and play a critical role in human cardiomyocytes remains to be defined. IP3Rs may be activated after Gαq-protein-coupled receptor...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.002764
更新日期:2013-09-17 00:00:00
abstract:BACKGROUND:Adverse cardiovascular events associated with thrombotic occlusion occur in 4% to 12.8% of patients after coronary angioplasty. Recently, potent antiplatelet agents have been used to reduce those thrombotic complications. Tirofiban is a highly selective, short-acting inhibitor of fibrinogen binding to platel...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.96.5.1445
更新日期:1997-09-02 00:00:00
abstract::The time of acute myocardial infarction was determined in all 1,741 patients of the ISAM (Intravenous Streptokinase in Acute Myocardial Infarction) Study, based on onset of clinical symptoms and evaluation of plasma CK-MB enzyme time-activity curves. The incidence of myocardial infarction was markedly increased betwee...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.4.853
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The cellular content of cAMP generated by activation of adenylylcyclase (AC) through the beta-adrenergic receptor (betaAR) is a key determinant of a cell's response to catecholamine stimulation. We tested the hypothesis that increased AC content, independently of betaAR number, increases responsiveness to ca...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.12.1618
更新日期:1999-03-30 00:00:00
abstract::Between 1973 and 1983, 90 patients with tricuspid atresia underwent the Fontan operation at the Mayo Clinic. Operative mortality was 12% overall and decreased to 7% during the second 5 year period. At postoperative follow-up of 65 patients (1 to 10 years, mean 4), 50 (86%) of 58 present survivors were in excellent con...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinase...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.921619
更新日期:2010-10-12 00:00:00
abstract:BACKGROUND:This article presents an update of the results achieved by modern surgery in congenital heart defects (CHDs) over the past 40 years regarding survival and the need for reoperations, especially focusing on the results from the past 2 decades. METHODS AND RESULTS:From 1971 to 2011, all 7038 patients <16 years...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.012033
更新日期:2015-01-27 00:00:00
abstract::Periodic fluctuations in the R-R interval have been used as noninvasive measures of cardiac autonomic tone. For example, a reduced heart rate variability has been shown to correlate with an increased mortality in patients recovering from myocardial infarction. The effects that physiologic perturbations such as exercis...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.1.146
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Pulmonary regurgitation frequently occurs after surgical correction of tetralogy of Fallot. To date, reliable quantitation of pulmonary regurgitation has not been possible, and therefore the clinical significance of pulmonary regurgitation is controversial. Nuclear magnetic resonance (NMR) velocity mapping a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.5.2257
更新日期:1993-11-01 00:00:00
abstract::Eight cases of ventricular parasystole are reported. In all these cases, regardless of whether parasystole seems intermittent or "continuous," the presence of second degree entrance block of the Mobitz type I was suggested. Parasystole alternated with concealed extrasystolic bigeminy showing occasional reentrant extra...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.4.715
更新日期:1978-10-01 00:00:00
abstract:BACKGROUND:Fibrinogen binding to the active conformation of the alpha(IIb)beta(3) integrin receptor (glycoprotein IIb/IIIa) and cytoskeletal reorganization are important events in platelet function. Tyrosine phosphorylation of platelet proteins plays an essential role in platelet signal transduction pathways. We studie...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.16.1924
更新日期:2000-10-17 00:00:00
abstract:BACKGROUND:The pulmonary autograft procedure (Ross) is now considered the gold standard for aortic valve replacement. One of its advantages is the freedom from macroemboli without anticoagulation. Whether this holds true for circulating microemboli, detectable as high-intensity transient Doppler signals (HITS), has not...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.6.1843
更新日期:1997-09-16 00:00:00
abstract::The acute coronary hemodynamic and metabolic effects of intravenous dipyridamole were studied in 13 patients. Total left ventricular (LV), anterior (supplied by the left anterior descending coronary artery) and inferior (supplied by circumflex and right coronary arteries) regional flows and metabolic responses were as...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.64.2.333
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:Endocarditis related to pacemaker (PM)-lead infection is a rare but serious complication of permanent transvenous pacing. To determine in which situations the diagnosis should be evoked and to determine optimal management, we reviewed our experience with endocarditis related to PM-lead infection. METHODS AN...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.95.8.2098
更新日期:1997-04-15 00:00:00
abstract:BACKGROUND:The Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX) trial demonstrated that in patients with 3-vessel or left main coronary artery disease, coronary artery bypass graft surgery (CABG) was associated with a lower rate of cardiovascular death, myocardial infarction, s...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.114.009985
更新日期:2014-09-30 00:00:00
abstract::R-wave synchronous equilbrium radionuclide angiography (RNA) is a noninvasive method that provides time-activity curve count information proportional to ventricular volumes and is used for relative volume comparisons within the left or right ventricle to derive the ejection fraction. Comparison of the ventricular coun...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.62.5.1089
更新日期:1980-11-01 00:00:00
abstract::Using a high-pressure liquid chromatographic assay, we measured serum amiodarone concentrations serially in 122 patients treated with amiodarone for 1.5-53 months (mean 9.3 months) for control of refractory symptomatic atrial or symptomatic and life-threatening ventricular tachyarrhythmias. The atrial tachyarrhythmias...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.67.6.1347
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:Convincing evidence suggests that atherosclerosis is an inflammatory disease. The inflammatory response is an important determinant of atherosclerotic plaque instability. Therefore, we investigated the prognostic impact of key inflammatory players, namely the inflammatory marker C-reactive protein (CRP) and ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000065232.57371.25
更新日期:2003-04-29 00:00:00