Can Whipple's disease be transmitted by gastroscopes?

Abstract:

OBJECTIVE:To determine whether disinfection protocols currently used for gastroscopes are effective against cultures of Tropheryma whipplei. DESIGN:The bactericidal activity of 2% glutaraldehyde and two peracetic acids on the Twist-Marseille strain of T. whipplei grown in cell monolayers was determined. PATIENTS:Two patients who were diagnosed as having Whipple's disease 3 years after they had had intestinal biopsies. RESULTS:The disinfectants reduced bacteria by approximately 2 log to 3 log10 after 5 to 60 minutes of contact. CONCLUSION:The bactericidal activity of a disinfectant is usually considered significant if it causes a 5 log10 or greater reduction in viable bacterial titers. Disinfecting gastroscopes with 2% glutaraldehyde or peracetic acids for 20 minutes may be insufficient to prevent transmission of T. whipplei on the instruments or stop false-positive results on polymerase chain reaction.

authors

La Scola B,Rolain JM,Maurin M,Raoult D

doi

10.1086/502188

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

191-4

issue

3

eissn

0899-823X

issn

1559-6834

pii

ICHE5038

journal_volume

24

pub_type

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