Abstract:
:In a randomised, double-blind study we compared the efficacy of continuous remifentanil infusion (0.25 microg x kg(-1) x min(-1) with 40 mg lidocaine and placebo in the prevention of injection pain due to intravenous propofol administration (1.5-2 mg x kg(-1)) in 155 patients scheduled for elective surgery. Pain severity was evaluated using a four-point scale. The incidence of injection pain was 62% in the placebo group and could be reduced significantly by using remifentanil (30%; p < 0.0015) or lidocaine (33%; p < 0.005). Analysis of the pain scores showed a significant difference between remifentanil and placebo (p < 0.00005) as well as between lidocaine and placebo (p < 0.0002). There was no significant difference between remifentanil and lidocaine. Remifentanil provided effective pain relief, comparable with lidocaine, and is an alternative as part of an intravenous anaesthesia regimen to using another concomitant drug.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Roehm KD,Piper SN,Maleck WH,Boldt Jdoi
10.1046/j.1365-2044.2003.02964_2.xsubject
Has Abstractpub_date
2003-02-01 00:00:00pages
165-70issue
2eissn
0003-2409issn
1365-2044journal_volume
58pub_type
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