Abstract:
OBJECTIVES:Ultrasound guided prostate biopsy is the most effective test for prostate cancer diagnosis, but its sensitivity is not higher than 80% so that biopsy repetition must be considered in patients with persistent diagnostic doubts after a previous negative one. However, the majority will be negative as it happened in the first biopsy and the percentage of normal biopsies increases successively. Various indexes based on PSA are proposed to determine which patients have a higher risk of cancer detection by biopsy. We evaluate the efficacy of PSA density (PSAD), free/total PSA ratio (F/T PSA) and PSA velocity (PSAV) to select patients with high PSA and previous negative biopsy. METHODS:546 patients who underwent more than one prostate biopsy were included in the study. 121 patients underwent 3 biopsies, 25 underwent 4 biopsies and 7 five biopsies, for a total of 1245 biopsies. Patients already diagnosed of prostate cancer who had received treatment, and postoperative urethrovesical anastomosis biopsies were excluded. Between 4 and 6 samples were obtained; transitional zone was included if previous biopsy was negative; sextant biopsy was repeated in high grade PIN, and 4 or 5 cores were taken from the affected side in cases with non conclusive glandular atypia. The relationship between PSAD, PSAV and F/T PSA and the diagnosis of cancer was evaluated, as well as its sensitivity, specificity, positive and negative predictive values. RESULTS:21.2% patients presented cancer on 2nd biopsy and 26% overall. Mean age was 68.3 years (51-84). Patients with cancer and negative biopsy showed significant differences in F/T PSA and PSAD, but not in PSAV. Sensitivities for PSAD higher than 0.15 ng/ml/ml, F/T PSA lower than 0.18 and PSAV higher than 0.75 ng/ml/year were 0.89, 0.9 and 0.49 respectively and specificities were 0.28, 0.2 and 0.4 respectively. ROC curve areas were calculated for these indexes being 0.63 for F/T PSA, and 0.47 for PSAV. CONCLUSIONS:Although their specificity is low, free to total PSA ratio and PSA density showed the highest sensitivity; PSAV is almost non valid to discriminate the result in the biopsy. Although we could slightly diminish the number of repeat biopsies loosing a few tumors, only the urologist can determine when biopsies should be repeated in patients with elevated PSA, taking into consideration all concurrent factors (Baseline status, age, risk-benefit ratio of new biopsies...).
journal_name
Arch Esp Uroljournal_title
Archivos espanoles de urologiaauthors
Rodríguez-Patrón Rodríguez R,Mayayo Dehesa T,González Galán A,Zuccarino AL,García González R,Cuesta Roca Csubject
Has Abstractpub_date
2002-12-01 00:00:00pages
225-34issue
10eissn
0004-0614issn
1576-8260journal_volume
55pub_type
杂志文章abstract:INTRODUCTION:Urosepsis is an underdiagnosed entity with high morbidity and mortality and significant associated costs. The delay in diagnosis leads to an increased risk of multiorgan failure and death. Although its prognosis is better than that of other sepsis, the mortality rate is 20 - 40%. OBJECTIVE:Describe the ob...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:The advances of minimally invasive surgery in urology over the last years have enabled a progressive and constant implementation of endourology and laparoscopy in pediatric patients. We perform a review of our experience, as a general hospital, with minimally invasive surgery performed in pediatric patients ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:Experimental data show the relationship between the area of injured urothelium and recurrence rates in superficial bladder cancer. Tumor cell adherence is increased by the exposure to the extracellular matrix (ECM). Transurethral resection uncovers the ECM and might lead to recurrent tumors. The question if ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Erectile dysfunction is not the only cause of impotence in the male; impotencia coeundi may result from various disorders, although cavernosal erectile function is normal. The present study reviews the congenital and acquired penile disorders, as well as the cutaneous disorders that may cause penile morphological chan...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To review the diagnostic and therapeutic aspects of carcinoma in situ of the testis, the preinvasive stage of testicular germ cell tumors. METHODS:The indications for performing testicular biopsy in patients with a higher incidence of testicular carcinoma in situ (patients with infertility, cryptorchidism an...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
abstract::The results of treatment of urethral strictures using the Sachse urethrotome in 31 patients are presented. These patients had consulted between 1985 and 1990 and were followed for a minimum of 6 months. The most common etiology in our series was iatrogenic (57.57%), particularly incorrect catheter placement. Single (6...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:To report a case of giant diverticulum of the bladder associated with inguinal hernia. METHODS/RESULTS:An uncommon case of giant diverticulum associated with inguinal hernia is presented and the literature reviewed. The enormous size of the diverticulum and the associated lower urinary tract obstruction aris...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::A retrospective review of 186 cases of transitional cell carcinoma of the bladder observed between 1987 and 1990 is described. Squamous metaplasia was present in 37 cases. This histological feature was especially found in association with poorly differentiated and invasive tumors: the presence of extensive areas of sq...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVES:To analyze the long-term results of treatment of urethral strictures by internal endoscopic urethrotomy, a simple, easily reproducible procedure that carries a low morbidity and requires a short period of convalescence. MATERIAL AND METHODS:We report our experience of 78 cases submitted to urethrotomy as pr...
journal_title:Archivos espanoles de urologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::A rare case of testicular malacoplakia is described herein. To our knowledge only 32 cases have been reported up to 1989. The microscopic features are described and the literature is briefly reviewed. ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00
abstract::Renal lithiasis is known for its high incidence and prevalence, but mainly for its morbidity and recurrence. Despite a good indication and appropriate surgical treatment, the essential problem, the origin of the formation of the stones, generally persists and it is not uncommon that patients suffer multiple treatments...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:The efficacy and morbidity of transurethral resection of the prostate (TURP) were evaluated in patients with urinary retention and prostatic carcinoma. METHODS:From 1990 to 1993, 30 patients with infravesical obstruction secondary to prostate cancer were treated by TURP. The results were considered good whe...
journal_title:Archivos espanoles de urologia
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVE:To study lytic lesions in a patient with past history of renal cancer. METHODS:A 62 year-old man was admitted to hospital for investigation of the cause of polyostotic bone pain. RESULTS:Brown tumors due to hyperparathyroidism turned out to be the cause of bone pain. CONCLUSIONS:Differential diagnosis is i...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:The growing interest on increasing the number of biopsy samples during ultrasound guided prostatic biopsies moved us to evaluate the tolerability and complications of the extensive biopsy with/without blockage of neurovascular bundles. METHODS:A group of 222 patients underwent prostatic biopsy with the aim ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:10.4321/s0004-06142005001000003
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:The management of stone disease in renal abnormalities is a challenge for urologist due to its rarity. The aim of the current manuscript is to report our experience in Retrograde Intrarenal Surgery (RIRS) in 4 complex-abdnormal cases using the flexible videoureterorrenoscopy. MATERIAL AND METHODS:Data was pr...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2020-04-01 00:00:00
abstract::We analyzed the results of surgical treatment of vesical neck sclerosis in 81 patients who underwent 97 procedures. Most of these patients had post-operative sclerosis of the vesical neck. The different surgical techniques and their results are reviewed. Excision of the sclerotic tissue by transurethral encircling res...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVES:To investigate the postoperative surgical complications and patient satisfaction with the outside-in transobturator tape (TOT) procedure performed by an experienced surgeon compared to those performed by residents in training. METHODS:Patients who received TOT surgery performed by a resident under supervisi...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2019-06-01 00:00:00
abstract::Our experience in stenosis of the urinary tract after renal transplantation is described. We reviewed the records of 160 consecutive cases of renal transplantation. The data gleaned over a period of 10 years (1982-1992) show a stenosis rate of 4.37%. All the cases were successfully treated by surgery. ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:We describe and document the first case of PEcoma published in Spain following the PubMed database. We review the bibliography about these tumors. METHODS/RESULTS:39 year-old female patient with a 9 cm pelvic tumor discovered in a routine gynecologic review. CT scan showed multiple periaortic adenopathies ex...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:To report the principles of penile resculpturing of different deformities caused by M. Peyronie: restoration of penile length, girth and shape with or without penile prosthesis implantation. METHODS:In the period between February 2007 and March 2009, we performed grafting surgery for M. Peyronie in 98 patie...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract::The author carries out a sonographic study on 200 expansive kidney processes, in which he assess the possibilities of this method of diagnosis at the same time offering the echographic semiology of the different disorders being studied. Finally, he explains the limitations and drawbacks of this technique. ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract::The authors present a case of sarcomatoid kidney adenocarcinome of the fibrosarcomatoid kind. They stress the importance and difficulty of making a differential diagnosis between the sarcomatoid type of kidney adenocarcinomas and pure sarcomas of the kidney, this being an entirely histopathological and extremely compl...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the current role of PSA as a diagnostic method for prostate cancer, as well as to analyze possible new markers. METHODS:We perform a bibliographic review for PSA, and its molecular forms, as a marker to define the presence of prostate cancer. We review the factors related to PSA modifications, p...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章,评审
doi:10.4321/s0004-06142006001000014
更新日期:2006-12-01 00:00:00
abstract::In the centenary of Dr. Luis Cifuentes Delatte we tell several histories about his teaching, which help to know and understand his professional and human quality. ...
journal_title:Archivos espanoles de urologia
pub_type: 传,历史文章,杂志文章
doi:10.4321/s0004-06142008001000010
更新日期:2008-12-01 00:00:00
abstract::To determine the usefulness of ultrasound in the diagnosis of acute renal graft failure, 48 renal transplants were retrospectively studied. The characteristic morphologic signs of acute rejection (AR) were compared with the histologic analysis of the graft using material obtained from percutaneous renal biopsy and/or ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:The authors present their experience in the management of a rare complication observed during long-term use of a ureteral catheter. The calcification along the entire surface of the catheter followed by incrustation can make its removal by means of cystoscopy difficult, thus becoming a great challenge to the ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To define, based on PSA value, Gleason score (GS), clinical stage and age, those patients diagnosed with asymptomatic prostate cancer whose cases warrant further study of bone metastasis (BMet). METHODS:From January 2006 to May 2010, we evaluated 263 patients diagnosed with prostate cancer who were chosen fo...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To describe an additional case of desmoid tumor of the penis. The incidence, etiopathogenesis, symptoms, diagnosis and treatment of this condition are discussed. METHODS:A 70-year-old male consulted at the emergency services for pain and urinary symptoms. Physical examination showed no regional lymphadenopat...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of the Anderson-Hynes pyeloplasty in 47 patients with pelviureteric junction syndrome and to compare our results with the reported results for open surgery and other techniques. METHODS:The records of 47 patients (21 males, 26 females) with pelviureteric junction syndrome treated at ...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:Serotonin and norepinephrine systems are involved in the neural control of lower urinary tract function. The aim of this study was to compare the response on striated anal sphincter electromyographic (SAS-EMG) activity and cystometric parameters, when duloxetine and clomipramine were intravenously administrat...
journal_title:Archivos espanoles de urologia
pub_type: 杂志文章
doi:10.4321/s0004-06142006000800019
更新日期:2006-10-01 00:00:00