[Current role of PSA and other markers in the diagnosis of prostate cancer].

Abstract:

OBJECTIVES:To evaluate the current role of PSA as a diagnostic method for prostate cancer, as well as to analyze possible new markers. METHODS:We perform a bibliographic review for PSA, and its molecular forms, as a marker to define the presence of prostate cancer. We review the factors related to PSA modifications, predictive models, or the current controversies about the usefulness of its cutpoint to define the risk of prostate cancer or the marker itself. We analyze possible new markers and the most interesting work lines in the development of new markers. We used MEDLINE for the bibliographic search. RESULTS:Available data confirm that PSA has a high sensitivity; although specificity is low, mainly in the < 10 ng/ml range, it may be increased with the use of various molecular isoforms, ratios or predictive models. Nevertheless, it is true that despite such studies it is difficult to increase specificity, so biopsies are reduced. Currently we have new markers, some of them already marketed, others in development, which seem to improve the specificity of PSA (isoforms, use of molecular biology). CONCLUSIONS:PSA is still the standard marker for the diagnosis of prostate cancer. It is important to improve the specificity; therefore we need new predictive models or new isoforms that help us to do a better selection of candidates for biopsy. There are various promising research lines with new markers, but there is not ideal substitute for PSA yet.

journal_name

Arch Esp Urol

authors

Gómez Veiga F,Ponce Reixa J,Barbagelata López A,Fernández Rosado E,Gonzaĺez Martiń M

doi

10.4321/s0004-06142006001000014

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1069-82

issue

10

eissn

0004-0614

issn

1576-8260

journal_volume

59

pub_type

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