[The influence of "differentiated trandurethral resection" in the recurrence and progression of superficial bladder cancer].

Abstract:

OBJECTIVES:Experimental data show the relationship between the area of injured urothelium and recurrence rates in superficial bladder cancer. Tumor cell adherence is increased by the exposure to the extracellular matrix (ECM). Transurethral resection uncovers the ECM and might lead to recurrent tumors. The question if recurrences are increased by enlarged urothelium resection areas is difficult to answer because there will be no prospective studies available. We investigated if deeper and larger urothelial injuries, which are caused by differentiated resections lead to higher recurrence and progression rates than regular resections of bladder tumors. METHODS:163 patients with superficial bladder cancer were retrospectively evaluated. Sixty-six received a differentiated resection and 97 a regular one. We analyzed the recurrence and progression rates over a minimum of 48 months as well as tumor persistence in the second resection. RESULTS:Patients with differentiated resections of bladder tumors were found to have no higher incidence of tumor recurrence and progression but showed a significantly higher percentage of tumor free second resections. CONCLUSIONS:As a model of enlarged urothelial lesions the differentiated resection technique for superficial bladder cancer has no negative influence on recurrence or progression rates. It seems unlikely that the extracellular matrix uncovered by resection is the main reason for the high recurrence rates. The significantly lower incidence of tumor persistence in the second resection favors the differentiated resection technique in the transurethral treatment.

journal_name

Arch Esp Urol

authors

Angbein S,Guzmán S,Haecker A,Weib C,Michel MS,Alken P,Siegsmund M

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

25-30

issue

1

eissn

0004-0614

issn

1576-8260

journal_volume

59

pub_type

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    authors: Matouschek E,Huber R

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