Clear cell renal cell carcinoma with osseous metaplasia: Two extremely rare cases and review of the literature.

Abstract:

OBJECTIVE:Renal cell carcinoma is constantly associated with calcification, but ossification is extremely scarce. METHOD: We retrospectively analyzed two cases with clear cell renal cell carcinoma with osseous metaplasia. RESULTS: We criticized the oldest case of woman whose a 32x31mm irregular renal mass with calcifications and we also mentioned about a diffusely calcified mass of 90 mm of a 68-year-old male patient. The histopathological examinations of both were reported as clear cell carcinoma with metaplastic bone formation. CONCLUSION: Although there are no definitive data on prognosis and follow-up due to the low number of cases; this entity usually occurs with early stage disease and a favorable prognosis as in our cases. While the prognostic importance of osseous metaplasia existence in renal cell carcinoma is controversial, such that can safely be managed with nephron sparing surgery in appropriate cases. As the number of cases and follow-up periods increased; more definitive information will be obtained. OBJETIVO:El carcinoma de células renales se asocia constantemente con la calcificación, pero la osificación es extremadamente escasa. MÉTODO: Analizamos retrospectivamente dos casos del carcinoma de células renales de células claras con metaplasia ósea. RESULTADOS: Criticamos el caso más antiguo de una mujer cuya masa renal irregular era de 32x31 mm con calcificaciones y también mencionamos una masa calcificada de forma difusa de 90 mm de un paciente masculino de 68 años. Los exámenes histopatológicos de ambos demostraron que se trataba del carcinoma de células claras con formación de hueso metaplásico. CONCLUSIÓN: Aunque, debido al bajo número de casos, no hay datos definitivos sobre el pronóstico y el seguimiento; esta entidad generalmente ocurre en un estadio temprano de la enfermedad con un pronóstico favorable como en nuestros casos. Si bien la importancia pronóstica de la existencia de metaplasia ósea en el carcinoma de células renales es controvertida, puede manejarse de manera segura con cirugía conservadora de nefronas en los casos apropiados. Dado el hecho de que se aumentó el número de casos y períodos de seguimiento, se obtendrá más información definitiva.

journal_name

Arch Esp Urol

authors

Cakici MC,Kır G,Akalın MK,Yıldırım A

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

651-654

issue

7

eissn

0004-0614

issn

1576-8260

pii

2020-73-7-38559b180927a8408a317a9920bf26c4a05094cc

journal_volume

73

pub_type

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