Parental presence during induction of anesthesia: physiological effects on parents.

abstract：BACKGROUND:: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are at an increased risk of cognitive impairment. The authors therefore have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice...

journal_title：Anesthesiology

authors： Shen X,Dong Y,Xu Z,Wang H,Miao C,Soriano SG,Sun D,Baxter MG,Zhang Y,Xie Z

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Because ephedrine infusion (2 mg/min) does not adequately prevent spinal hypotension during cesarean delivery, the authors investigated whether adding phenylephrine would improve its efficacy. METHODS:Thirty-nine parturients with American Society of Anesthesiologists physical status I-II who were scheduled ...

journal_title：Anesthesiology

authors： Mercier FJ,Riley ET,Frederickson WL,Roger-Christoph S,Benhamou D,Cohen SE

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Clinically used general anesthetics, alone or in combination, are damaging to the developing mammalian brain. In addition to causing widespread apoptotic neurodegeneration in vulnerable brain regions, exposure to general anesthesia at the peak of synaptogenesis causes learning and memory deficiencies later i...

journal_title：Anesthesiology

authors： Sanchez V,Feinstein SD,Lunardi N,Joksovic PM,Boscolo A,Todorovic SM,Jevtovic-Todorovic V

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Inflammation is a key element in the pathophysiology of cerebral ischemia. This study investigated the role of N-Myc downstream-regulated gene-2 in nuclear transcription factor κB-mediated inflammation in ischemia models. METHODS:Mice (n = 6 to 12) with or without nuclear transcription factor κB inhibitor p...

journal_title：Anesthesiology

authors： Deng YL,Ma YL,Zhang ZL,Zhang LX,Guo H,Qin P,Hou YS,Gao ZJ,Hou WG

更新日期：2018-03-01 00:00:00

abstract：:The effect of neuromuscular blockade with vecuronium on the hemodynamic responses to a noxious stimulus was investigated in male Sprague-Dawley rats. The rats were anesthetized with either halothane (group 1, n = 10), or isoflurane (group 2, n = 10). The maximum values for heart rate and mean arterial pressure during ...

journal_title：Anesthesiology

authors： Gibbs NM,Larach DR,Schuler HG

更新日期：1989-08-01 00:00:00

abstract：INTRODUCTION:The knowledge on the mechanism of the postoperative exacerbation of sleep-disordered breathing may direct the perioperative management of patients with obstructive sleep apnea. The objective of this study is to investigate the factors associated with postoperative severity of sleep-disordered breathing. M...

journal_title：Anesthesiology

authors： Chung F,Liao P,Elsaid H,Shapiro CM,Kang W

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:In vitro, halothane appears to affect the role played by nitric oxide in the regulation of vascular tone and cardiac function. In vivo, the results of the interactions between halothane and the nitric oxide pathway remain controversial. The authors investigated the effects of halothane on the cardiac and reg...

journal_title：Anesthesiology

authors： Chelly JE,Doursout MF,Lechevalier T,Liang YY,Chelly F,Hartley C,Kilbourn RG

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Experimental and clinical studies have shown reduction in intrapulmonary shunt with improved oxygenation by spontaneous breathing with airway pressure release ventilation (APRV) in acute lung injury. The mechanisms of these findings are not clear. The authors hypothesized that spontaneous breathing results i...

journal_title：Anesthesiology

authors： Wrigge H,Zinserling J,Neumann P,Defosse J,Magnusson A,Putensen C,Hedenstierna G

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Left ventricular diastolic function is known to be impaired in patients with coronary artery disease and patients with valvular aortic stenosis. Phenylephrine is frequently administered as an intravenous bolus in these patients perioperatively to increase coronary perfusion pressure. Although this is common ...

journal_title：Anesthesiology

authors： Goertz AW,Lindner KH,Schütz W,Schirmer U,Beyer M,Georgieff M

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Initial postoperative core temperature is a physician and hospital performance measure. However, the extent to which core temperature changes during emergence from anesthesia and transport from the operating room to the postanesthesia care unit (PACU) remains unknown. Similarly, the accuracy of many noninvas...

journal_title：Anesthesiology

authors： Langham GE,Maheshwari A,Contrera K,You J,Mascha E,Sessler DI

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Optimal management of anesthesia-induced respiratory depression requires identification of the neural pathways that are most effective in maintaining breathing during anesthesia. Lesion studies point to the brainstem retrotrapezoid nucleus. We therefore examined the respiratory effects of common anesthetic/a...

journal_title：Anesthesiology

authors： Bourgeois T,Ringot M,Ramanantsoa N,Matrot B,Dauger S,Delclaux C,Gallego J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Electrical stimulation of acupuncture point P6 reduces the incidence of postoperative nausea or vomiting (PONV) in adult patients. However, acupressure, laser stimulation of P6, and acupuncture during anesthesia have not been effective for reducing PONV in the pediatric population. The authors studied the ef...

journal_title：Anesthesiology

authors： Rusy LM,Hoffman GM,Weisman SJ

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Optimal analgesia for total knee arthroplasty remains challenging. Many modalities have been used, including peripheral nerve block, periarticular infiltration, and epidural analgesia. However, the relative efficacy of various modalities remains unknown. The authors aimed to quantify and rank order the effic...

journal_title：Anesthesiology

authors： Terkawi AS,Mavridis D,Sessler DI,Nunemaker MS,Doais KS,Terkawi RS,Terkawi YS,Petropoulou M,Nemergut EC

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The transfusion of erythrocytes that have been stored for long periods of time can produce visceral ischemia and favor the acquisition of postsurgical infections. To estimate the role of the duration of storage of erythrocytes on morbidity in cardiac surgery, we performed an observational study. METHODS:All...

journal_title：Anesthesiology

authors： Leal-Noval SR,Jara-López I,García-Garmendia JL,Marín-Niebla A,Herruzo-Avilés A,Camacho-Laraña P,Loscertales J

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Some studies suggest that the orbicularis oculi is resistant to neuromuscular blocking drugs and behaves like laryngeal muscles. Others report little or no difference between the orbicularis oculi and the adductor pollicis. These discrepancies could be related to the exact site of recording. The purpose of t...

journal_title：Anesthesiology

authors： Plaud B,Debaene B,Donati F

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Dysrhythmias and death occur in patients with acquired long QT syndrome (LQTS). Little information exists regarding interactions between anesthetics and drugs that prolong ventricular repolarization. Therefore the effects of three commonly used intravenous anesthetics on ventricular repolarization were inves...

journal_title：Anesthesiology

authors： Morey TE,Martynyuk AE,Napolitano CA,Raatikainen MJ,Guyton TS,Dennis DM

更新日期：1997-11-01 00:00:00

abstract：:The effects of increased intracranial pressure (ICP) and increased cardiac output (QT) on the pulmonary vascular response to regional alveolar hypoxia were compared in pentobarbital-anesthetized, closed-chested dogs. A bronchial divider was inserted, the right lung (RL) was continuously ventilated with 100% O2, and th...

journal_title：Anesthesiology

authors： Domino KB,Hlastala MP,Cheney FW

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor 1 (PAI-1) attenuates the conversion of plasminogen to plasmin. Polymorphisms of the PAI-1 gene are associated with varying PAI-1 levels and risk of prothrombotic events in nonsurgical patients. The purpose of this study, a secondary analysis of a clinical trial, was to investi...

journal_title：Anesthesiology

authors： Iribarren JL,Jimenez JJ,Hernández D,Brouard M,Riverol D,Lorente L,de La Llana R,Nassar I,Perez R,Martinez R,Mora ML

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:In animals, systemic and intrathecal administration of the alpha2 -adrenergic receptor agonist dexmedetomidine results in robust antinociceptive effects in models of heat pain. In humans, systemically administered dexmedetomidine is approved for sedating patients in the intensive care unit. However, whether ...

journal_title：Anesthesiology

authors： Angst MS,Ramaswamy B,Davies MF,Maze M

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:The dose-response relation for spinal ropivacaine is undetermined, and there are few data available for obstetric patients. METHODS:In a prospective, randomized, double-blind investigation, the authors studied 72 patients undergoing elective cesarean delivery. An epidural catheter was placed at the L2-L3 ve...

journal_title：Anesthesiology

authors： Khaw KS,Ngan Kee WD,Wong EL,Liu JY,Chung R

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Intrathecal methylprednisolone acetate (MPA) has been used in patients with chronic pain syndromes. Its safety has been debated after reports of adverse events. No systematic preclinical evaluation of MPA has been reported. In the current study, the acute and long-term effects of intrathecal MPA on dog spina...

journal_title：Anesthesiology

authors： Rijsdijk M,van Wijck AJ,Kalkman CJ,Meulenhoff PC,Grafe MR,Steinauer J,Yaksh TL

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Myocardial contractility is regulated by intracellular concentration of free Ca2+ ([Ca2'],) and myofilament Ca2+ sensitivity. The objective of this study was to elucidate the direct effects of thiopental on cardiac excitation-contraction coupling using individual, field-stimulated ventricular myocytes. METH...

journal_title：Anesthesiology

authors： Kanaya N,Zakhary DR,Murray PA,Damron DS

更新日期：1998-07-01 00:00:00

abstract：:Perioperative myocardial ischemia is associated with an increased risk of perioperative myocardial infarction (PMI). Several attempts have been made to define intraoperative hemodynamic predictors of myocardial ischemia. In a canine preparation with coronary stenosis, a pressure rate quotient (PRQ = mean arterial pres...

journal_title：Anesthesiology

authors： Gordon MA,Urban MK,O'Connor T,Barash PG

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Postoperative nausea and vomiting continue to be a significant problem for pediatric ambulatory surgery patients. Although ondansetron has been demonstrated to be effective in the prophylactic treatment of postoperative nausea and vomiting (surrogate end point) no one has demonstrated a benefit of antiemetic...

journal_title：Anesthesiology

authors： Davis PJ,McGowan FX Jr,Landsman I,Maloney K,Hoffmann P

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Cardiac surgery requiring the use of cardiopulmonary bypass is frequently complicated by coagulopathic bleeding that, largely due to the shortcomings of conventional coagulation tests, is difficult to manage. This study evaluated a novel transfusion algorithm that uses point-of-care coagulation testing. MET...

journal_title：Anesthesiology

authors： Karkouti K,McCluskey SA,Callum J,Freedman J,Selby R,Timoumi T,Roy D,Rao V

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Lidocaine inhalation attenuates histamine-induced bronchospasm while evoking airway anesthesia. Because this occurs at plasma concentrations much lower than those required for intravenous lidocaine to attenuate bronchial reactivity, this effect is likely related to topical airway anesthesia and presumably in...

journal_title：Anesthesiology

authors： Groeben H,Grosswendt T,Silvanus MT,Pavlakovic G,Peters J

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Patients who receive a combination of a benzodiazepine and an opioid for conscious sedation are at risk for developing respiratory depression. While flumazenil effectively antagonizes the respiratory depression associated with a benzodiazepine alone, its efficacy in the presence of both a benzodiazepine and ...

journal_title：Anesthesiology

authors： Gross JB,Blouin RT,Zandsberg S,Conard PF,Häussler J

更新日期：1996-10-01 00:00:00

abstract：:Reversal of the usual relationship between aortic and radial artery pressure can occur in patients following cardiopulmonary bypass. Radial systolic (and often radial mean) pressures were lower, relative to aortic pressure, after cardiopulmonary bypass than before bypass in all 18 patients studied. The systolic pressu...

journal_title：Anesthesiology

authors： Stern DH,Gerson JI,Allen FB,Parker FB

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Adding sodium bicarbonate to lidocaine to enhance its efficacy during peripheral nerve block is controversial. The authors studied the effect of adding sodium bicarbonate to lidocaine with and without epinephrine versus equivalent alkalinization by sodium hydroxide (NaOH) on onset, degree, and duration of pe...

journal_title：Anesthesiology

authors： Sinnott CJ,Garfield JM,Thalhammer JG,Strichartz GR

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Thermoregulatory vasoconstriction minimizes further core hypothermia during anesthesia. Elderly patients become more hypothermic during surgery than do younger patients, and take longer to rewarm postoperatively. These data indicate that perianesthetic thermoregulatory responses may be especially impaired in...

journal_title：Anesthesiology

authors： Kurz A,Plattner O,Sessler DI,Huemer G,Redl G,Lackner F

更新日期：1993-09-01 00:00:00