Enterovirus infection during pregnancy is not a risk factor for celiac disease in the offspring.

Abstract:

BACKGROUND:There is a strong genetic influence on the susceptibility to celiac disease but it is also evident that environmental factors play a role in the development of the disease. Diverging studies about adenovirus infection as a possible triggering factor in the pathogenesis have been reported. Our study was undertaken to determine whether enterovirus infection during pregnancy is a risk factor for the development of celiac disease later in childhood. METHODS:Cord blood from 76 mothers whose children developed celiac disease before 15 years of age were analyzed for IgA, IgG, and IgM antibodies for enteroviruses and Ig-A endomysium antibodies. The control group comprised cord blood from 327 mothers with children without known celiac disease. RESULTS:There were no significant differences in antibody titers for enterovirus between the two groups. IgA-endomysium antibodies were elevated in 3 of the 76 mothers, whereas none had known celiac disease. CONCLUSION:This study does not show that enterovirus infection during pregnancy is associated with the development of celiac disease in childhood. Of the mothers whose children developed celiac disease, 4% had Ig-A endomysium antibodies, which may reflect a silent celiac disease.

authors

Carlsson AK,Lindberg BA,Bredberg AC,Hyöty H,Ivarsson SA

doi

10.1097/00005176-200211000-00011

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

649-52

issue

5

eissn

0277-2116

issn

1536-4801

journal_volume

35

pub_type

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