Abstract：
INTRODUCTION:The current advances in the field of human genetics allow for the development of alternative therapies for the treatment of diseases affecting the central nervous system (CNS). One of the most promising new therapies is the use of therapeutic genes or gene therapy. OBJECTIVE:To briefly review the recent advances for the treatment of diseases affecting the CNS. DEVELOPMENT:We consider the therapeutic strategies currently in study for gene therapy of diseases with neurologic symptoms as monogenic diseases, CNS malignancies and neurodegenerative diseases. We describe the pros and cons of viral, non viral vectors and cell based therapy. CONCLUSIONS:The current gene therapy approaches allow for specific and efficient administration of therapeutic genes to the CNS. Despite the need of optimization of the available vectors, mainly regarding to safety and efficacy, gene therapy has an important potential for the treatment of neuropediatric diseases.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Bosch Asubject
Has Abstractpub_date
2002-07-16 00:00:00pages
158-62issue
2eissn
0210-0010issn
1576-6578pii
rn2002124journal_volume
35pub_type
杂志文章,评审abstract：INTRODUCTION:Strachan's disease is a condition which mainly affects the nervous system. It is characterized by optic, auditory and peripheral neuropathies and lesions of the skin and mucous membranes. In 1955 Miller Fisher gave it this name, since the clinical condition described by Henry Strachan in Jamaica during the...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:The association of unilateral ptosis and contralateral palpebral retraction named as "palpebral plus-minus syndrome" by Gaynard et al is an infrequent finding. Most cases described are of peripheral origin and secondary to muscle pathology or neuromuscular union. Cases secondary to central lesions are exceptional. We ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：AIMS:In this study we review the economic impact involved in suffering from this disease in an attempt to determine how it affects both the individual and society, and the potential benefits deriving from its prevention and treatment. DEVELOPMENT:The World Health Organisation and the World Bank have pointed out that 9...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Myasthenia gravis is an autoimmune disease of the neuromuscular junction that presents clinically as fluctuating weakness of skeletal muscles, as of the ocular region (myasthenia ocular). AIM:To demonstrate that the sensitivity and specificity of the ice pack test are high, in the differential diagnosis o...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:'Sword stroke' linear scleroderma, which is better known as linear scleroderma en coup de sabre (LSCS), is a rare disease with an uncertain causation that is characterised by progressive craniofacial focal atrophy and is, at least in part, different from Parry-Romberg syndrome (PRS). CASE REPORTS:Here, we...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:Numerous drugs have been related to exacerbation of myasthenia gravis. So far there are no studies examining the extent of use of drugs related to exacerbation of myasthenia gravis. AIMS:We sought to assess the extent of use of drugs related to exacerbations and the annual incidence rate of exacerbations ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：10.33588/rn.7104.2020198
更新日期：2020-08-16 00:00:00
abstract：INTRODUCTION:«Man-in-the-barrel» syndrome refers to diplegia of the upper extremities in which mobility of the head and lower limbs is preserved. Brachial plexitis that presents as «man-in-the-barrel» syndrome is an unusual manifestation of giant cell arteritis. We report a case of C5-C6 plexitis as part of the clinica...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:The occupational environment generates a large amount of illness which involves several specialities, including neurology. However, there is little awareness--or little training--in this field as in most medical specialities, since in the basic tool of a doctor's work, the clinical history, importance is s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：TITLE:Epilepsia dependiente de piridoxina por deficiencia en el gen PNPO. ...
journal_title：Revista de neurologia
pub_type： 信件
doi：10.33588/rn.6907.2019084
更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION:Arterial gas embolism (AGE) is a main iatrogenic complication resulting from the use of invasive procedures. It is difficult to diagnose if it is not clinically suspected. CASE REPORT:A 67-year-old male patient, with a history of interventions involving a mitral prosthesis and a double aortocoronary bypas...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：INTRODUCTION:Epilepsy is a chronic disease with high prevalence. Its impact in the quality of life is influenced by factors like disease characteristics, comorbidities, stigma perception and treatment adherence. AIM:To assess the quality of life, the social stigma and the treatment adherence of patients with epilepsy ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-10-16 00:00:00
abstract：INTRODUCTION:In the early stages of their development, children acquire the skills and knowledge that provide them with the foundations on which they will later add what they learn at school, including skills such as reading, writing and mathematics. The presence of learning difficulties at the infantile stage can affe...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2006-02-13 00:00:00
abstract：AIM:The aim is to review the molecular and genetic aspects of the dystrophic and no dystrophic myotonias. BACKGROUND:Myotonic diseases are hereditary conditions of the skeletal muscle, classified in two groups depending on the symptoms. In the first group are the myotonic dystrophies, with the myotonic dystrophies typ...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2004-04-01 00:00:00
abstract：INTRODUCTION:The differential diagnosis of diseases that are accompanied by adult-onset girdle weakness is broad and includes motor neurone, neuromuscular junction or muscular diseases. The 8344A>G mutation of the MTTK gene of mitochondrial DNA usually presents with involvement of multiple organs associated (or not) wi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2018-04-16 00:00:00
abstract：:It has been stated that findings in neonatal neurological examinations can play a role as a pointer to adverse developmental outcome. The description of the examinations, and their presence or absence differed among authors without clear reference to their physiological variability ranges. We approached the study of s...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：INTRODUCTION:Cavernous angiomas account for 5-13% of all vascular malformations. In 75% of cases they are situated in the posterior fossa and up to 30% are associated with abnormal venous drainage. The main complication is haemorrhage; the presence of a neurological focus without radiological evidence of bleeding is ve...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：INTRODUCTION:Infantile autism is a disorder that is characterised by alterations affecting reciprocal social interactions, abnormal verbal and non-verbal communication, poor imaginative activity and a restricted repertoire of activities and interests. The causes of autism remain unknown, but there are a number of diffe...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-02-27 00:00:00
abstract：INTRODUCTION:The surgery of epilepsy is expanding considerably all over the world. It is becoming a standard treatment in patients who are resistant to conventional medical treatment. DEVELOPMENT:In this article we explain the methodology used by the authors and suggest concepts regarding the epileptogenous area. We a...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-16 00:00:00
abstract：:INTRODUCTION. A large number of neurological diseases course with impairment of higher cognitive functions, their evaluation being important for diagnostic, prognostic and therapeutic purposes. The main purpose of neuropsychological assessment is to identify behavioral, emotional and cognitive consequences of brain dy...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2014-12-16 00:00:00
abstract：INTRODUCTION:Lyme disease is a complex infectious disease affecting multiple organic systems. The most frequent complications are of a dermatological, rheumatological, ophthalmological, cardiac and neurological nature. Among the neurological complications, pseudotumour cerebri is considered to be a rare manifestation o...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-04-16 00:00:00
abstract：OBJECTIVE:To review the mechanisms involved in the appearance of respiratory failure in patients with neuromuscular disorders. DEVELOPMENT:The development of respiratory failure in patients with weakness of the respiratory muscles secondary to neuromuscular disease is not only due to the disease itself. There are also...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2001-01-01 00:00:00
abstract：INTRODUCTION:The inmuno checkpoints inhibitors are new revolutionary treatment for many neoplastic diseases in advanced stadium. There are described several types of neurological complications induced by nivolumab: polyneuropathy, seizures, radiculitis and myasthenia gravis disease. CASE REPORT:A 65 years old man with...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：10.33588/rn.6808.2018497
更新日期：2019-04-16 00:00:00
abstract：:What appears in this article is nothing more than a series of reflections on psychiatry and neurology based on my own experience as an educator, practitioner and scholar of both disciplines. It is not, therefore, a piece of research work in the usual sense of the word. Such has been my commitment to Revista de Neurolo...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2007-12-16 00:00:00
abstract：INTRODUCTION:Unilateral isolated paralysis of the soft palate is a rare clinical entity. CASE REPORT:We describe the case of a 12 year old girl who presented acute dysphagia, a nasal voice and regurgitation of liquids into the nose. Exploration revealed right velopalatine insufficiency with normal gag reflex and phary...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-02-15 00:00:00
abstract：INTRODUCTION:A spinal cord injury implies the loss of or alteration to the gait pattern. Stimulating the pattern generating centres in the sublesional spinal cord determines the appearance of flexion and extension automatisms that are useful for gait training in patients with spinal cord injuries. These centres can be ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：INTRODUCTION:Recent studies suggest that furosemide (FUR), a chloride cotransporting antagonist, acts directly on neurons of central nervous system modifying the ionic flow. OBJECTIVE:The aim of the present study was to determine the extrarenal antiedema effect of FUR. MATERIAL AND METHODS:Male Sprague-Dawley rats we...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical, electro-encephalographic and evolutionary characteristics of a series of patients diagnosed as having benign neonatal sleep myoclonus (BNSM). MATERIAL AND METHODS:The clinical histories of 21 patients with BNSM were analyzed. Criteria for inclusion in the study were: neonates who ha...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-04-01 00:00:00
abstract：:The term 'acute myelopathies'--referred to a spinal cord dysfunction--represent a heterogeneous group of disorders with distinct etiologies, clinical and radiologic features, and prognoses. The objective of this review is to discuss the non-traumatic acute myelopathies. Acute myelopathy can be due to several causes as...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-06 00:00:00
abstract：INTRODUCTION:Although subjective memory complaints are one of the most common causes behind visits to health services, there are hardly any validated instruments in Spanish for evaluating their magnitude. Since memory complaint questionnaires usually include items referring to attentional and executive aspects, it has ...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：AIM:To document reversible cognitive deterioration associated to high doses of zonisamide, using the Reliable Change Index to control practice effects derived from repetitive neuropsychological assessments. CASE REPORT:A 11 year-old boy with tuberous sclerosis complex and left frontal refractory epilepsy, evaluated wi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2015-01-16 00:00:00
