Abstract:
:A significant proportion of patients with coronary artery disease have symptoms refractory to medical treatment, yet are unsuitable for conventional revascularization techniques, like percutaneous coronary intervention and coronary artery bypass surgery. Such patients are potential candidates for alternative forms of coronary revascularization, like therapeutic angiogenesis. This strategy is designed to promote the development of supplemental collateral blood vessels that will act as endogenous bypass conduits. Two major avenues for achieving therapeutic angiogenesis are currently under intense investigation: gene therapy (the introduction of new genetic material into somatic cells to synthesize proteins that are missing, defective, or desired for specific therapeutic purposes) and protein-based therapy (administration of the growth factors, instead of the genes encoding for the growth factors responsible for angiogenesis). This article provides a concise review of the "components" of gene and protein-based therapy, namely, the growth factors, the vector (for gene therapy), the route of delivery, the therapeutic target, the desired therapeutic effect, and quantifiable clinical end points for trials of angiogenesis. Based on preliminary studies, the authors believe that therapeutic angiogenesis represents a promising novel therapy for treatment of the ischemic heart. In the future, angiogenesis will likely be offered as an adjunct to conventional revascularization strategies in subsets of patients who are only "suboptimally" revascularized with conventional techniques, and might evolve into a stand-alone treatment for some patients with nonrevascularizable disease.
journal_name
J Interv Cardioljournal_title
Journal of interventional cardiologyauthors
Harjai KJ,Chowdhury P,Grines CLdoi
10.1111/j.1540-8183.2002.tb01062.xsubject
Has Abstractpub_date
2002-06-01 00:00:00pages
223-9issue
3eissn
0896-4327issn
1540-8183journal_volume
15pub_type
杂志文章,评审abstract::Transcatheter aortic valve replacement (TAVR) has emerged as an attractive option for patients with severe symptomatic aortic stenosis (AS) who are either at high risk or extreme risk for surgical aortic valve replacement (SAVR). This article summarizes the major advances in TAVR that were published or reported in 201...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/joic.12274
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Current guidelines recommend coronary artery bypass grafting (CABG) for patients with multivessel coronary disease and left ventricular (LV) dysfunction. However, some patients undergo percutaneous coronary intervention (PCI) or solely medical therapy (MT) in actual practice. The comparison of long-term ou...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12497
更新日期:2018-06-01 00:00:00
abstract::Coronary angiography, despite its inherent invasiveness and need for contrast media and radiographic exposure, is still routinely employed every year for the diagnostic and therapeutic management of millions of patients with or at risk for coronary artery disease. Whereas approximate visual estimation is the most comm...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/j.1540-8183.2009.00491.x
更新日期:2009-12-01 00:00:00
abstract:Objectives:We aimed to identify mechanical and pharmacological revascularization strategies correlated with the index of microcirculatory resistance (IMR) in ST-elevation myocardial infarction (STEMI) patients. Background:Microvascular dysfunction (MVD) after STEMI is correlated with infarct size and poor long-term pr...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2020/5036396
更新日期:2020-07-09 00:00:00
abstract::Four different types of occluder systems were used to close a persistent foramen ovale (PFO) in 162 patients with paradoxical embolic events. Ninety-eight patients had ischemic stroke, 60 transient ischemic attacks (TIA) or prolonged reversible ischemic neurological deficit (PRIND), and 4 had peripheral arterial embol...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2001.tb00740.x
更新日期:2001-04-01 00:00:00
abstract::Forty patients undergoing percutaneous transluminal coronary angioplasty (PTCA) with severely impaired left ventricular ejection fraction (LVEF) < 30% were randomized between prophylactic intraaortic balloon pump (IABP) support (N = 20) and percutaneous cardiopulmonary bypass (PCPB) support (N = 20). The indications f...
journal_title:Journal of interventional cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1540-8183.1995.tb00532.x
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Routine use of adjunctive devices to percutaneous coronary intervention (PCI) for the treatment of patients of ST-segment elevation myocardial infarction (STEMI) is questionable. Also, the clinical characteristics of STEMI patients that can modulate the treatment benefits of adjunctive devices are not fully ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,meta分析
doi:10.1111/j.1540-8183.2008.00420.x
更新日期:2009-02-01 00:00:00
abstract::We sought to determine if advances in percutaneous coronary intervention (PCI) are associated with better outcomes among patients with diabetes mellitus (DM). Patients with DM enrolled in the National Heart, Lung, and Blood Institute (NHLBI) early PTCA Registry (1985-1986) were compared to those in the subsequent cont...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2006.00211.x
更新日期:2006-12-01 00:00:00
abstract::Different coils have been used to close the patient ductus arteriosus (PDA). In small- and moderate-sized PDA, coils are an adequate alternative to surgery and/or to other devices. The aim of the study is to review and discuss the advantages and disadvantages of using coils (excluding PFM coils PFM Medical, Germany) t...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1046/j.1540-8183.2003.08029.x
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND: Twelve-month dual antiplatelet therapy (DAT) with aspirin and clopidogrel after drug-eluting stent (DES) implantation is routinely recommended. It is unclear if prolonged (>12-month) DAT is also favorable. We compared the outcome of patients discontinuing DAT 12 months after off-label DES implantation versu...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2011.00713.x
更新日期:2012-12-01 00:00:00
abstract:Background:Urinary kidney injury molecule 1 (uKIM-1) is a proximal tubular injury biomarker for predicting acute kidney injury (AKI); its prognostic value varies depending on the clinical and population characteristics. However, the predictive value of uKIM-1 for diagnosis of contrast-induced acute kidney injury (CI-AK...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,meta分析
doi:10.1155/2020/4982987
更新日期:2020-08-13 00:00:00
abstract::Local delivery of immunosuppressive or antiproliferative agents using a drug-eluting stent is a new technology that is supposed to inhibit in-stent restenosis, thus providing a biological and mechanical solution. This technique is a very promising. To date, several agents have been used, including paclitaxel, QP-2, ra...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/j.1540-8183.2002.tb01091.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To examine the long-term outcome of the stent fracture (SF) and the potential predictive factors contributing to in-stent restenosis (ISR) in the fractured stent. BACKGROUND:The SF is thought to be a higher risk of ISR in drug-eluting stent, although SF does not always develop ISR. METHODS:The consecutive 1...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2010.00614.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Main purpose of this study is to emphasize the usage and safety of transthoracic echocardiography (TTE) in percutaneous atrial septal defect (ASD) closure in appropriate pediatric cases. BACKGROUND:Nowadays, percutaneous closure is preferred as treatment modality for ASD in pediatric age group. METHODS:Betw...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12197
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:The present study assesses clinical outcomes in patients from the Potential Angina Class Improvement From Intramyocardial Channels (PACIFIC) trial of percutaneous transmyocardial revascularization (PTMR) who had previously been considered "no-option," but who subsequently underwent percutaneous coronary inte...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2004.00325.x
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To assess long-term outcome and parameters associated with poor and favorable outcome in patients with a left ventricular ejection fraction (LV-EF) ≤25% and severe mitral regurgitation (MR) after percutaneous edge-to-edge mitral valve repair (pMVR). BACKGROUND:There is no data on long-term outcome in this co...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12193
更新日期:2015-04-01 00:00:00
abstract::The aim of this study was to review current studies relevant to the link between impaired glucose tolerance (IGT), diabetes, and cardiovascular disease. Cardiovascular disease is a major cause of the reduction in life expectancy in patients with diabetes. Seventy-five percent of diabetic patients die prematurely of ca...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/j.1540-8183.2005.00080.x
更新日期:2005-12-01 00:00:00
abstract::This case report and subsequent literature review describes the management difficulties in a patient who developed abciximab-induced thrombocytopenia and gastrointestinal bleeding. Abciximab was used to treat the no-reflow phenomenon, which occurred during insertion of three sequential Taxus coronary artery stents. Re...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2007.00296.x
更新日期:2008-02-01 00:00:00
abstract:AIMS:In severe myocardial dysfunction, extracorporeal life support (ECLS) can preserve organ perfusion. Occasionally, the high resulting afterload can lead to refractory pulmonary edema. We report our experience with percutaneous balloon atrioseptostomy used in this circumstance to discharge the left heart and prevent ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2011.00681.x
更新日期:2012-02-01 00:00:00
abstract::Alcohol septal ablation is increasingly being offered as a therapy for patients with hypertrophic obstructive cardiomyopathy. The procedure is most often performed in stable patients with a history of increasing symptoms. We describe a patient with hypertrophic obstructive cardiomyopathy with an acute decompensation s...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2005.00069.x
更新日期:2005-10-01 00:00:00
abstract::The reliability, rapidity, and safety of nonsurgical, transatrial pericardial access for local cardiac therapy have been demonstrated in healthy animals. Since many patients take aspirin or have increased right-sided pressures, we evaluated the procedure's safety under these conditions. Transatrial pericardial access ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2001.tb00364.x
更新日期:2001-10-01 00:00:00
abstract::Dextrocardia is a rare anomaly affecting 0.01% of newborns. We report on a case of a 60-year-old female with mirror-image dextrocardia who presented with an acute myocardial infarction and underwent primary angioplasty of the left circumflex artery. A review of the literature and technical challenges of the case will ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2005.00350.x
更新日期:2005-04-01 00:00:00
abstract::Transcatheter dilatation is considered the elective treatment of residual coarctation. In the presence of native coarctation, dilatation is often effective but in the first months of life, and the risk of aneurysm formation is not low. The use of stents in adolescents and adults provides excellent results and seems to...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1046/j.1540-8183.2003.01004.x
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The transradial approach for coronary procedures is associated with a low complication rate, but specific training is considered mandatory. METHODS:Procedural characteristics (contrast dye: CD; fluoroscopy time: FT, patient radiation dose: RD) and local complication rates were prospectively assessed in 784 ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2010.00603.x
更新日期:2011-02-01 00:00:00
abstract:Aim:To investigate the relationship between stent length and changes in microvascular resistance during PCI in stable coronary artery disease (CAD). Methods and Results:We measured fractional flow reserve (FFR), index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) before and after stenting in 42...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2019/1397895
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Intramyocardial injection of bone marrow cells (BMC) in refractory angina patients with chronic myocardial ischemia has shown to be safe and improve clinical status during short-term follow-up. However, scarce data are available on long-term (>12 months) safety and efficacy. Therefore, the occurrence of clin...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12408
更新日期:2017-10-01 00:00:00
abstract::The concept of the "vulnerable" plaque has recently emerged to explain how quiescent atherosclerotic lesions evolve to cause clinical events. The morphologic and immunologic determinants specific for the vulnerable plaque have been reported: a large lipid core (>or=40% plaque volume) composed of free cholesterol cryst...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/j.1540-8183.2005.00090.x
更新日期:2005-12-01 00:00:00
abstract::Catheter-based vascular interventions have been in development worldwide for several decades, leading to remarkable progress in device technology. Mechanical interventional devices, such as angioplasty balloons, atherectomy devices, and stents, were invented and have contributed greatly to the treatment of atheroscler...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/j.1540-8183.2002.tb01070.x
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:There is limited comparative clinical data regarding the safety and efficacy profile of paclitaxel delivery via balloon versus stent-polymer matrix. In this study, we aimed to compare the clinical and angiographic results of two different methods of paclitaxel delivery among patients undergoing percutaneous ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/joic.12210
更新日期:2015-08-01 00:00:00
abstract::While coronary revascularization strategies guided by instantaneous wave-free ratio (iFR) are, in general, noninferior to those guided by fractional flow reserve (FFR) with respect to the rate of major adverse cardiac events at one-year follow-up in patients with stable angina or an acute coronary syndrome, the overal...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2020/4094121
更新日期:2020-05-11 00:00:00