Abstract:
:Local delivery of immunosuppressive or antiproliferative agents using a drug-eluting stent is a new technology that is supposed to inhibit in-stent restenosis, thus providing a biological and mechanical solution. This technique is a very promising. To date, several agents have been used, including paclitaxel, QP-2, rapamycin, actinomycin D, dexamethason, tacrolimus, and everolimus. Several studies, published recently or still ongoing, have evaluated these drugs as to their release kinetics, effective dosage, safety in clinical practice, and benefit. These studies include: SCORE (paclitaxel derivative), TAXUS I-VI, ELUTES, ASPECT, DELIVER (paclitaxel), RAVEL, SIRIUS (sirolimus), ACTION (actinomycin), EVIDENT, PRESENT (tacrolimus), EMPEROR (dexamethason), and FUTURE (everolimus). Paclitaxel was one of the first stent-based antiproliferative agents under clinical investigation that provided profound inhibition of neointimal thickening depending on delivery duration and drug dosage. The randomized, multicenter SCORE trail (Quanam stent, paclitaxel-coated) enrolled 266 patients at 17 sites. At 6-month's follow-up, a drop of 83% in stent restenosis using the drug-eluting stent could be achieved (6.4% drug-eluting stent vs 36.9% control group), which was attributable to a remarkable decrease in intimal proliferation. Unfortunately, due to frequent stent thrombosis and side-branch occlusions, the reported 30-day MACE rate was 10.2%. The randomized TAXUS-I safety trial (BSC, NIRx, paclitaxel-coated) also demonstrated beneficial reduction of restenotic lesions at 6-month's follow-up (0% vs 10%) but was associated with the absence of thrombotic events presumably due to less drug dosage. The ongoing TAXUS II-VI trials are addressing additional insight regarding the efficacy of the TAXUS paclitaxel-eluting stent. ASPECT and ELUTES evaluated paclitaxel-coated stents (i.e., Cook and Supra G), including subgroups with different drug dosages. With respect to stent restenosis and neointimal proliferation, both studies demonstrated a clear dose response. The RAVEL and the SIRIUS trials evaluated sirolimus-coated stents (i.e., Cordis, Johnson & Johnson, and Bx VELOCITY stents). Results confirmed the beneficial findings regarding reduction of renarrowing using a drug-eluting stent without any major adverse effects. Although parameters such as drug toxicity, optimal drug dosage, or delayed endothelial healing still need to be evaluated, today's clinical experience indicates that drug-coated stents are extremely beneficial in the interventional treatment of coronary lesions.
journal_name
J Interv Cardioljournal_title
Journal of interventional cardiologyauthors
Grube E,Büllesfeld Ldoi
10.1111/j.1540-8183.2002.tb01091.xsubject
Has Abstractpub_date
2002-12-01 00:00:00pages
471-5issue
6eissn
0896-4327issn
1540-8183journal_volume
15pub_type
杂志文章,评审abstract:Objective:The aim of this study was to compare feasibility, effectiveness, safety, and outcome of atrial septal defect (ASD) device closure in children with and without fluoroscopy guidance. Methods and Results:Children undergoing transcatheter ASD closure between 2002 and 2016 were included into this single center, r...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2019/6598637
更新日期:2019-04-07 00:00:00
abstract:Background:Transcatheter aortic valve implantation (TAVI) is currently recommended for patients with severe aortic stenosis at intermediate or high surgical risk. The decision process during TAVI evaluation includes a thorough benefit-risk assessment, and knowledge about long-term benefits and outcomes may improve pati...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2019/4292987
更新日期:2019-10-01 00:00:00
abstract:Objectives:The aim of this study was to assess the clinical impact of 3 bifurcation angles in left main (LM) bifurcation treated with the 2-stent technique. Background:Data are limited regarding the impact of bifurcation angles after LM percutaneous coronary intervention (PCI). Methods:Using patient-level 4 multicent...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2020/2475930
更新日期:2020-07-11 00:00:00
abstract:BACKGROUND:Optimal management of multivessel disease (MVD) in ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PCI) is still unclear. OBJECTIVES:To compare short- and long-term clinical outcomes of early-staged, angio-guided approach and delayed, ischem...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1540-8183.2011.00666.x
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:The authors investigated safety and efficacy of the MitraClip-System (MCS) using a systematic analysis. BACKGROUND:The safety and efficacy of the MCS continues to be debated, and randomized trials are still lacking. METHOD:A systematic literature search was conducted using common medical and scientific dat...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/joic.12168
更新日期:2015-02-01 00:00:00
abstract::Forty patients undergoing percutaneous transluminal coronary angioplasty (PTCA) with severely impaired left ventricular ejection fraction (LVEF) < 30% were randomized between prophylactic intraaortic balloon pump (IABP) support (N = 20) and percutaneous cardiopulmonary bypass (PCPB) support (N = 20). The indications f...
journal_title:Journal of interventional cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1540-8183.1995.tb00532.x
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:While the efficacy of drug-eluting coronary stents (DES) has been demonstrated by several clinical trials, the impact of DES on health-care costs and recipient quality of life (QOL) is controversial. We performed a systematic review of the published literature on DES costs and the QOL effects of restenosis a...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/j.1540-8183.2007.00214.x
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Paradoxical embolization from right-to-left shunt (RLS) resulting in neurological events is well described and patients with cryptogenic neurological disease are commonly evaluated for this condition. In the course of testing for RLS by bubble contrast transcranial Doppler (TCD), we observed that some patien...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2010.00557.x
更新日期:2010-06-01 00:00:00
abstract:INTRODUCTION:Hemostasis following transradial cardiac catheterization is achieved by external pressure application using various devices, TR Band being one. There is no standardized protocol for the application and removal of such devices. OBJECTIVE:To assess the safety and feasibility of a more rapid (1 hour) initiat...
journal_title:Journal of interventional cardiology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1540-8183.2009.00501.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:To determine whether drug-eluting stent (DES) coronary complete revascularization (CR) confers clinical benefit over incomplete revascularization (IR) in patients with multivessel coronary artery disease (MVD). BACKGROUND:Clinical benefit of CR over IR in patients with MVD with angina (both stable and unsta...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/joic.12390
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Drug-eluting stents have been shown to reduce the incidence of restenosis and target vessel revascularization (TVR) compared with bare metal stents (BMSs); however, the long-term efficacy of sirolimus-eluting stent (SES) implantation in patients with acute coronary syndrome (ACS) has not been w...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2009.00446.x
更新日期:2009-06-01 00:00:00
abstract::A group of 312 patients who underwent percutaneous coronary intervention for bifurcation lesions at 12 centers in China, Singapore, Thailand, Israel, India, and Japan were enrolled in a prospective, randomized DKCRUSH-1 trial. The goal of the study was to compare the double kissing (DK) crush technique with the classi...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1540-8183.2009.00440.x
更新日期:2009-04-01 00:00:00
abstract::Catheter-based vascular interventions have been in development worldwide for several decades, leading to remarkable progress in device technology. Mechanical interventional devices, such as angioplasty balloons, atherectomy devices, and stents, were invented and have contributed greatly to the treatment of atheroscler...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
doi:10.1111/j.1540-8183.2002.tb01070.x
更新日期:2002-10-01 00:00:00
abstract:INTRODUCTION:Irrigated tip radiofrequency ablation of cardiac arrhythmias was developed to increase the size of the radiofrequency-induced lesion, since cooling of the electrode tip allows use of higher power settings. The purpose of this study was to determine if the increased lesion size during irrigated tip ablation...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2004.09879.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVES:We present our single center experience with Medtronic CoreValve and Evolut R regarding procedural outcome and 3 years follow-up in patients with degenerated bioprostheses. METHODS:From 1645 patients who underwent transfemoral TAVI at our institution between February 2009 and December 2016, 37 patients with...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12498
更新日期:2018-06-01 00:00:00
abstract::Aims To compare clinical outcome in Chronic kidney disease (CKD) patients receiving coronary stents according to stent type BMS versus DES and 1st generation versus 2nd generation DES. Methods and Results PubMed, Cinhal, Cochrane, Embase, and Web of Science were searched for studies including CKD patients. CKD was def...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/joic.12473
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:The valve-in-valve (VIV) technique is an emerging therapeutic option for patients with failure of previously implanted xenografts. We describe a balloon-expandable transthoracic transapical mitral VIV implantation in an emergency setting in a 69-year-old woman with dysfunction of the mitral bioprosthesis. M...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2011.00637.x
更新日期:2011-10-01 00:00:00
abstract::Percutaneous intervention of tortuous coronary arteries can be challenging. We describe four cases that illustrate complications associated with coronary tortuosity (coronary dissection and stent loss) and strategies that can improve procedural success (such as use of soft delivery catheters, deep guide intubation, me...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2008.00374.x
更新日期:2008-12-01 00:00:00
abstract::Dextrocardia is a rare anomaly affecting 0.01% of newborns. We report on a case of a 60-year-old female with mirror-image dextrocardia who presented with an acute myocardial infarction and underwent primary angioplasty of the left circumflex artery. A review of the literature and technical challenges of the case will ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2005.00350.x
更新日期:2005-04-01 00:00:00
abstract::This case report and subsequent literature review describes the management difficulties in a patient who developed abciximab-induced thrombocytopenia and gastrointestinal bleeding. Abciximab was used to treat the no-reflow phenomenon, which occurred during insertion of three sequential Taxus coronary artery stents. Re...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2007.00296.x
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:The transradial approach for coronary procedures is associated with a low complication rate, but specific training is considered mandatory. METHODS:Procedural characteristics (contrast dye: CD; fluoroscopy time: FT, patient radiation dose: RD) and local complication rates were prospectively assessed in 784 ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2010.00603.x
更新日期:2011-02-01 00:00:00
abstract::An intravascular ultrasonic imaging device (40 MHz) was used to obtain in vitro ultrasonic images and matching histologic cross-sections, derived from human vascular specimens. The feasibility of assessing vessel wall morphology as well as the ability to accurately document plaque thickness was determined. Based on ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.1991.tb01008.x
更新日期:1991-01-01 00:00:00
abstract::Paravalvular leaks are a recognized complication of valve replacement surgery. We report a 47-year-old man with left atrial isomerism, interrupted left sided inferior caval vein with unilateral left sided superior caval vein, a common atrium, and anomalous pulmonary venous connection to the coronary sinus, who had rec...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2007.00290.x
更新日期:2007-12-01 00:00:00
abstract::The 6Fr Hydrolyser thrombectomy catheter for acute myocardial infarction (AMI) successfully removed a massive thrombus in the coronary artery in three patients. The 6Fr Hydrolyser catheter could be advanced into the right coronary artery with bare-wire methods via a 6Fr sheath at the radial artery. This approach sugge...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2001.tb00356.x
更新日期:2001-08-01 00:00:00
abstract::We discuss the case of a 61-year-old male patient with hypertrophic cardiomyopathy and chest pain on exertion. Coronary angiography and intravascular ultrasound revealed an intermediate stenosis in the proximal site of the left anterior descending artery, while Tc-99m myocardial scintigraphy revealed exercise-induced ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2002.tb01029.x
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Left main coronary artery (LMCA) disease is associated with significant cardiovascular mortality. The data on patient characteristics' predicting outcomes after LMCA revascularization is sparse. METHODS:A retrospective study of 227 patients with LMCA disease documented on coronary angiography from March 200...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2013.12012.x
更新日期:2013-02-01 00:00:00
abstract:UNLABELLED:The aim of this study was to determine the impact of previous with cytomegalovirus (CMV) on restenosis after aggressive angioplasty with provisional stenting. DESIGN:We prospectively studied 78 consecutive patients scheduled for 6-month follow-up coronary angiography as part of the SIPS study. Anti-CMV IgG ...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1034/j.1600-6143.2003.08060.x
更新日期:2003-08-01 00:00:00
abstract:Objectives:We aimed to identify mechanical and pharmacological revascularization strategies correlated with the index of microcirculatory resistance (IMR) in ST-elevation myocardial infarction (STEMI) patients. Background:Microvascular dysfunction (MVD) after STEMI is correlated with infarct size and poor long-term pr...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2020/5036396
更新日期:2020-07-09 00:00:00
abstract:OBJECTIVE:Main purpose of this study is to emphasize the usage and safety of transthoracic echocardiography (TTE) in percutaneous atrial septal defect (ASD) closure in appropriate pediatric cases. BACKGROUND:Nowadays, percutaneous closure is preferred as treatment modality for ASD in pediatric age group. METHODS:Betw...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12197
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:There were insufficient data on the prognosis of stenting for patients with trifurcated unprotected left main lesions (UPLMS). METHODS:From the SPEED (stents for percutaneous treatment of coronary artery disease) registry of all percutaneous coronary interventions (PCI) for all types of UPLMS, data of 44 pa...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2010.00569.x
更新日期:2010-08-01 00:00:00