Abstract:
BACKGROUND AND OBJECTIVE:Drug-eluting stents have been shown to reduce the incidence of restenosis and target vessel revascularization (TVR) compared with bare metal stents (BMSs); however, the long-term efficacy of sirolimus-eluting stent (SES) implantation in patients with acute coronary syndrome (ACS) has not been well established. We have investigated the long-term clinical outcome of SES in patients with ACS. METHODS:Consecutive 245 patients with ACS treated by primary stenting within 24 hours after onset were enrolled. There were 128 patients treated with SES and 117 patients were treated with BMS. We evaluated the incidence of major cardiac events (MACE; total death, nonfatal myocardial infarction, TVR) at 3 years, comparing with 8-month clinical outcome. RESULTS:Eight-month clinical follow-up shows a significantly lower incidence of TVR in the SES group, 3.1% in the SES group versus 9.4% in the BMS group (P = 0.04). At 3-year clinical follow-up, there was no significant difference in the rate of TVR between the two groups, 8.4% versus 12.4% (P = 0.37). Cumulative incidence of total MACE was 9.2% in the SES group compared with 15.9% in the BMS group (P = 0.18). Only one case of stent thrombosis was observed in the SES (late thrombosis), while two cases of stent thrombosis occurred in the BMS group (late and very late thrombosis; P = 0.55). CONCLUSION:SES implantation in patients with ACS is associated with favorable long-term clinical outcome with no excess of late stent thrombosis. Further long-term clinical follow-up will be warranted to confirm the safety and efficacy of SES.
journal_name
J Interv Cardioljournal_title
Journal of interventional cardiologyauthors
Ogita M,Nakamura T,Fujiwara N,Sakakura K,Funayama H,Sugawara Y,Kubo N,Ako J,Momomura Sdoi
10.1111/j.1540-8183.2009.00446.xsubject
Has Abstractpub_date
2009-06-01 00:00:00pages
216-21issue
3eissn
0896-4327issn
1540-8183pii
JOIC446journal_volume
22pub_type
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pub_type: 杂志文章,meta分析
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abstract:OBJECTIVE:The following retrospective observational study assesses the long-term results of intracoronary beta-radiation therapy for patients with in-stent restenosis. BACKGROUND:Beta-radiation has been used to treat patients with coronary in-stent restenosis. However, long-term clinical success using this technique h...
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