Abstract:
OBJECTIVES:To determine what clinical, analytic and ultrasound parameters, are more effective to predict the result of a second biopsy in patient with high PSA and a first prostate biopsy negative. MATERIAL AND METHODS:It was carried out a longitudinal study in a series of 435 cases with negative prostate biopsy. In 59 of these cases it was practiced a second biopsy due to a permanent or sudden high PSA levels with or without a suspicious digital rectal examination. Of the 31 cases with a negative second biopsy, in 4 cases it was carried out a third biopsy. The biopsy was made in all the occasions by transrectal ultrasound guided sextant biopsy. It were also valued the ultrasound characteristic of the prostate, the prostate volume and the proportion of free PSA. RESULTS:It was demonstrated statistically significant differences among the patients with a second biopsy negative and positive regarding: the age, proportion of free PSA, abnormal digital rectal examination and presence of hipoechogenic areas in the prostate. The multivariate analysis demonstrated that the only significant parameters were the proportion of free PSA and the existence of an abnormal digital rectal examination. Based on the data of multivariate analysis, we settled down for the patients with normal digital rectal examination a cut-off point of 0.23 of proportion of free PSA as indication for the realization of a second biopsy, and of 0.59 for the patients with abnormal digital rectal examination. This protocol applied to our series would avoid the realization of a second biopsy in 8 patients, and a third biopsy in 1 patient, diagnosing all the cases of prostate cancer. CONCLUSIONS:The digital rectal examination associated with the proportion of free PSA constitutes a reliable parameter to indicate the realization of a second prostate biopsy in patient with high PSA and previous negative biopsy.
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Valer Algarabel J,Agüera Fernández L,Adot Zurbano JM,Virseda Chamorro M,Marcos Díaz J,Gómez López A,Alpuente Román C,Plaza Martos JAdoi
10.1016/s0210-4806(02)72757-5subject
Has Abstractpub_date
2002-03-01 00:00:00pages
196-203issue
3eissn
0210-4806issn
1699-7980pii
S0210-4806(02)72757-5journal_volume
26pub_type
杂志文章abstract:INTRODUCTION:There is a need for a precise and reliable imaging to improve the management of prostate cancer. In recent years the PET/CT with choline has changed the handling of prostate cancer in Europe, and it is commonly used for initial stratification or for the diagnosis of a biochemical recurrence, although it do...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
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abstract::A case of unilateral cavernosal body abscess appears after fifteen days of 40 degrees C fever, without urological symptoms. The diagnosis started from a big scrotum aedema, related of a local septic focus in the left cavernosal body. ECO and TAC confirmed the diagnosis, and a surgical treatment was required. After a s...
journal_title:Actas urologicas espanolas
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abstract::Some feasibility problems were detected during the evaluation of the IPSS questionnaire in Spanish that might limit its application. Our initial experience with the IPSS in patients undergoing surgery had 3 aims: 1) assess if changes in format and wording will improve feasibility; 2) evaluate symptoms before and after...
journal_title:Actas urologicas espanolas
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更新日期:1995-03-01 00:00:00
abstract:RATIONALE:To investigate whether, in the same way incidence is affected, biological aggressiveness of bladder cancer at diagnosis is greater in men than in women. METHOD:Using data from a retrospective study on urothelial cancer of the bladder between 1975 and 1991 in La Rioja (Spain), an estimate was made of total Re...
journal_title:Actas urologicas espanolas
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更新日期:1998-01-01 00:00:00
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journal_title:Actas urologicas espanolas
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abstract::Long-term results obtained in 54 surgical procedures to correct effort urinary incontinence performed in 49 patients with this pathology are reviewed. One group was treated with suprapubic urethrovesical suspension with the Marshall-Marchetti-Krantz technique; the other group with endoscopic suspension of the neck of ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
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journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
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更新日期:1999-02-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Actas urologicas espanolas
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journal_title:Actas urologicas espanolas
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更新日期:1989-09-01 00:00:00
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更新日期:2005-04-01 00:00:00
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journal_title:Actas urologicas espanolas
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pub_type: 杂志文章,多中心研究
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journal_title:Actas urologicas espanolas
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更新日期:1992-11-01 00:00:00
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journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1999-05-01 00:00:00