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Liquid biopsy and prostate cancer. Current evidence applied to clinical practice.

Abstract：

CONTEXT:Despite being a validated source of biomarkers, liquid biopsy has not yet succeeded in becoming part of the standard clinical practice in prostate cancer patients. Few biomarkers undergo adequate validation, prospective and independent, of their predictive and/or prognostic value, which results in a lack of the different available tests in the clinical practice. OBJECTIVE:To carry out a pragmatic synthesis of current scientific evidence on liquid biopsy for prostate cancer patients. EVIDENCE ACQUISITION:Non-systematic literature review, narrowing the search to papers on liquid biopsy from blood samples in prostate cancer patients. We mainly selected works evaluating clinical endpoints in prostate cancer. EVIDENCE SYNTHESIS:The most clinically advanced forms of liquid biopsy are circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Both CTCs and ctDNA have demonstrated their prognostic value in metastatic disease. ARV7 determination is the first predictive biomarker of the disease. Its implementation into routine clinical practice requires methodological standardization and adequate clinical validation of the different available ways to detect it. The detection of CTCs in the early stages of the disease still depends on the optimization of the diagnostic methods and on the development of the biological characterization of these cells. The biological information provided by CTCs and ctDNA is different; therefore, the study of its adequate combination is the object of cutting-edge research. CONCLUSIONS:The absence of protocols and methodological standards is the limiting factor when aiming to reach conclusions that could have a potential impact on clinical practice. Therefore, the real short-term challenge for liquid biopsy is the establishment of consensus and common criteria.

journal_name

Actas Urol Esp

journal_title

Actas urologicas espanolas

authors

Puche-Sanz I,Rodríguez-Martínez A,Garrido-Navas MC,Robles-Fernández I,Vázquez-Alonso F,Álvarez Cubero MJ,Lorente-Acosta JA,Serrano-Fernández MJ,Cózar-Olmo JM

doi

10.1016/j.acuro.2019.08.007

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

139-147

issue

eissn

0210-4806

issn

1699-7980

pii

S0210-4806(19)30169-X

journal_volume

pub_type

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Liquid biopsy and prostate cancer. Current evidence applied to clinical practice.