Abstract：
PURPOSE:To document keratocyte distribution and changes with age in the cellular network of the human cornea in vivo. SETTING:Department of Ophthalmology, University of Rostock, Rostock, Germany. METHODS:Forty-nine eyes of 31 healthy subjects of various ages were examined with a modified Microphthal scanning-slit confocal microscope (SSCM) (Hund) to document keratocyte distribution in the intact living cornea. Optical sections made by confocal microscopy were recorded on videotape, and the keratocyte density was determined for the total volume of the cornea and for the stromal sublayers. RESULTS:The highest cell density was in the anterior stroma of the cornea immediately posterior to Bowman's membrane (24 320 cells/mm(3) +/- 6740 [SD]), the lowest in the central area (11,610 +/- 4290 cells/mm(3)), and an intermediate density in the posterior stroma immediately adjacent to Descemet's membrane (18,850 +/- 4610 cells/mm(3)). The differences were statistically significant (P <.005). The keratocyte density was significantly lower in the anterior and posterior regions in the group older than 50 years: Cell density at 4% depth was 20,960 +/- 8200 cells/mm(3) and at 96%, 15 520 +/- 4290 cells/mm(3) (P <.05). CONCLUSIONS:In healthy living corneas, the keratocyte density was high in the areas adjacent to Bowman's and Descemet's membranes and was lower in patients older than 50 years than in those younger than 50 years. Further studies are needed to document the rate of change with age and to better understand the role and capacity of aging keratocytes in regenerative processes following corneal diseases or surgical procedures.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Berlau J,Becker HH,Stave J,Oriwol C,Guthoff RFdoi
10.1016/s0886-3350(01)01227-5subject
Has Abstractpub_date
2002-04-01 00:00:00pages
611-6issue
4eissn
0886-3350issn
1873-4502pii
S0886335001012275journal_volume
28pub_type
杂志文章abstract：PURPOSE:To investigate the long-term effect of phacoemulsification on intraocular pressure (IOP) in patients with ocular hypertension and open-angle glaucoma. SETTING:Three multispecialty ophthalmology practices and one glaucoma specialty group. DESIGN:Retrospective comparative case series. METHODS:Review of medical...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrs.2012.01.016
更新日期：2012-05-01 00:00:00
abstract：:Over a 12 month period, we used the anterior chamber maintainer (ACM) in cataract surgery in 258 patients; ages ranged from 15 to 95 years (mean 73 years). Surgery was performed using general or local anesthesia. The procedures were standard extracapsular cataract extraction (ECCE), mini-nuc ECCE, vectis extraction of...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(96)80214-8
更新日期：1996-03-01 00:00:00
abstract：PURPOSE:To validate changes in intraocular pressure (IOP) after phacoemulsification with intraocular lens (IOL) implantation without pressure-lowering surgery in previously unoperated eyes of normal and glaucoma patients. SETTING:University Eye Clinic, Otto-von-Guericke-University, Magdeburg, Germany. DESIGN:Cohort s...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.11.034
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:To understand, demonstrate, and further research the mechanisms of accommodation and presbyopia. SETTING:Private practice, Little Silver, New Jersey, USA. DESIGN:Experimental study. METHODS:The CAMA 2.0 computer-animated model of accommodation and presbyopia was produced in collaboration with an experienced ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2014.07.028
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:To quantify the cyclorotation occurring between wavefront measurement and laser refractive surgery. SETTING:LaserVue Eye Center Ophthalmic Clinic, Santa Rosa, California, USA. METHODS:The pupil camera of the Visx WaveScan wavefront device was used to obtain images of 51 eyes (26 patients) from 5 to 20 minutes...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2003.08.022
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:To evaluate the safety and efficacy of Intacs inserts in keratoconic eyes to alter corneal shape and refractive power and stabilize the progression of corneal ectasia. SETTING:Service d'Ophtalmologie, Bordeaux, France. METHODS:In this prospective study, 57 eyes with clear central corneas that were diagnosed w...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrs.2006.01.064
更新日期：2006-05-01 00:00:00
abstract：:A modified version of peribulbar anesthesia is described. An analysis of 230 consecutive ophthalmic procedures including cataract surgery, penetrating keratoplasty, and scleral buckling demonstrates the safety and effectiveness of this modified peribulbar anesthesia technique. ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(88)80156-1
更新日期：1988-07-01 00:00:00
abstract：PURPOSE:To evaluate the postoperative intraocular positional stability of 1 rigid poly(methyl methacrylate) (PMMA) phakic intraocular lens (pIOL) model and 2 foldable polysilicone-PMMA iris-fixated pIOL models. SETTING:Department of Ophthalmology, Johann Wolfgang Goethe-University Frankfurt am Main, Germany. METHODS:...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2007.08.037
更新日期：2008-01-01 00:00:00
abstract：:The ocular response analyzer (ORA) (Reichert, Inc.) was used in the case of a middle-aged man who developed unilateral corneal ectasia after bilateral laser in situ keratomileusis (LASIK). The preoperative refraction was similar in the 2 eyes. Post-LASIK ectasia was central in the left eye; topography was oblate in th...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2007.11.018
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:To assess the effect of preoperative tear function on early changes in functional visual acuity (FVA) after laser in situ keratomileusis (LASIK). SETTING:Minamiaoyama Eye Clinic, Tokyo, Japan. METHODS:This prospective single-center study assessed the effect of preoperative and postoperative tear functions on ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.02.086
更新日期：2004-11-01 00:00:00
abstract：PURPOSE:To use capsule dyes to enhance visualization to learn and perform various critical steps of the phacoemulsification procedure in a laboratory setting using postmortem human eyes. SETTING:Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charle...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(00)00363-1
更新日期：2000-07-01 00:00:00
abstract：PURPOSE:To report 4 cases of Pseudomonas aeruginosa endophthalmitis caused by internal contamination of the internal pathways of a phacoemulsifier. SETTING:Ophthalmology Center, Perpignan, France. METHODS:Four clinical cases of postoperative endophthalmitis occurred after phacoemulsification. An investigation was nec...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)80052-2
更新日期：1999-04-01 00:00:00
abstract：PURPOSE:To compare short-term refractive and visual acuity outcomes after topography-guided laser in situ keratomileusis (LASIK) planned with a new topography analysis system to those based on the manifest refraction. SETTING:Four clinical sites in the United States. DESIGN:Double-arm, nonmasked, nonrandomized retros...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000176
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To compare the coaxial light intensity required during cataract surgery, and rate of postoperative visual recovery, with surgical visualization achieved with a traditional analog operating microscope compared to a 3D digital visualization system. SETTING:Weill Cornell Medical Center, New York Presbyterian Hosp...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000448
更新日期：2020-09-24 00:00:00
abstract：PURPOSE:To compare the effects of fluidic parameters on the central corneal thickness (CCT), corneal endothelium, and anterior segment inflammation after phacoemulsification with longitudinal ultrasound. SETTING:Iladevi Cataract & IOL Research Center, Ahmedabad, India. METHODS:In this prospective randomized patient- ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2009.11.009
更新日期：2010-04-01 00:00:00
abstract：:We present a case of late traumatic flap dislocation 47 months after laser in situ keratomileusis (LASIK). This is the latest reported case of traumatic LASIK flap dislocation to date. The patient was examined 5 days after being struck in the face and found to have a flap dislocation. The flap was repositioned surgica...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2005.01.022
更新日期：2005-08-01 00:00:00
abstract：:Contrast sensitivity was measured in 25 patients who had a multifocal diffractive intraocular lens and in 23 control patients with a monofocal lens in four simulated light conditions: (1) daylight, (2) daylight with peripheral glare, (3) twilight, (4) twilight with central glare. In normal daylight and twilight, contr...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80952-2
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:To assess the performance of a partial coherence interferometry (PCI)-based device for the determination of anterior segment biometry. SETTING:Clinica Centrofama, Cartagena, Murcia, Spain. METHODS:Central corneal thickness (CCT), anterior chamber depth (ACD), and lens thickness (LT) were measured with the ACM...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.10.038
更新日期：2009-02-01 00:00:00
abstract：:A 25-year-old woman with moderate myopia presented for refractive surgery. Bilateral femtosecond laser-assisted small-incision lenticule extraction (SMILE) was scheduled and her right eye was completed smoothly. However, during the lenticule cutting of her left eye, a large inferior black area was noted. The operation...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000185
更新日期：2020-06-01 00:00:00
abstract：:A 56-year-old man developed a nasal field defect in his left eye 3 months after a traumatic accident. An examination showed a posterior subcapsular cataract in the left eye with no neurologic deficits. Humphrey 24-2 visual field testing revealed a nasal hemianopsia in the left eye. After cataract extraction and intrao...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00152-2
更新日期：1999-09-01 00:00:00
abstract：PURPOSE:To present a complex surgical technique used for the management of luxated crystalline lenses and evaluate treatment results. SETTING:Department of Ophthalmology, Medical University of Lodz, Lodz, Poland. METHODS:This prospective study involved 29 consecutive patients (30 eyes) with the mean age of 60.3 years...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2005.04.039
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:To assess the incidence, risk factors, and impact on visual outcomes of an opaque bubble layer (OBL) produced by an Intralase femtosecond laser (60 kHz) during laser in situ keratomileusis (LASIK). SETTING:Laser Vision Center, Chang Gung Memorial Hospital, Keelung, Taiwan. DESIGN:Case series. METHODS:Patient...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.08.055
更新日期：2014-03-01 00:00:00
abstract：:We describe a variation of stop and chop phacoemulsification. During chopping the chopper's vertical element is depressed posteriorly toward the optic nerve and is placed well within the capsulorhexis margin, leading to in situ chopping. Each fragment is continuously chopped, and the small pieces are stuffed inside th...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,评审
doi：10.1016/s0886-3350(96)80003-4
更新日期：1996-06-01 00:00:00
abstract：PURPOSE:To investigate the prevalence of preoperative cataract surgery testing and consultation at a single United States teaching hospital. SETTING:Academic-affiliated Veterans Affairs Medical Center. DESIGN:Retrospective chart review. METHODS:This study included patients who received cataract surgery from 2014 to ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000153
更新日期：2020-06-01 00:00:00
abstract：:For one year we followed 46 eyes that had photoastigmatic refractive keratectomy with an excimer laser to correct simple myopic astigmatism. Mean preoperative cylinder was -2.50 +/- 0.70 diopters (D); mean preoperative best corrected visual acuity was 20/25 +/- 1 Snellen line. Mean postoperative refraction one year af...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80207-6
更新日期：1995-09-01 00:00:00
abstract：PURPOSE:To evaluate anterior chamber angle alterations after phakic intraocular lens (pIOL) implantation using the Pentacam rotating Scheimpflug camera (Oculus) and the effect on intraocular pressure (IOP) and anterior chamber inflammation. SETTING:Department of Ophthalmology, Keio University School of Medicine, Tokyo...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.04.033
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To demonstrate the proper method for evaluating and reporting astigmatism for individual and aggregate data. SETTING:University of Texas Medical School and Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. METHODS:The surgically induced refractive change (SIRC) was determined for three da...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(98)80075-8
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To compare the efficiencies of the operative procedures and the reductions in postoperative corneal endothelial cell density (ECD) after cataract surgery using 2 different phacoemulsification tips and their associated cassettes and tubing. SETTING:Wolfe Clinic, Marshalltown, Iowa, USA. METHODS:A randomized pr...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0886-3350(99)00201-1
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:To analyze anterior segment structure changes during accommodative stimuli after monofocal intraocular lens (IOL) implantation using 2 ultrasound biomicroscopy (UBM) systems. SETTING:Department of Ophthalmology, University of Verona, Verona, Italy. METHODS:Twenty-six eyes (23 patients) with 1 of 4 monofocal I...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.02.018
更新日期：2008-06-01 00:00:00
abstract：:We compared the effect of biconvex and convex-plano (posterior plano) intraocular lenses on posterior capsule opacification (PCO) following continuous curvilinear capsulorhexis (CCC) in 212 eyes. During the three years following surgery, the cumulative frequency of neodymium:YAG laser posterior capsulotomy, calculated...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80569-x
更新日期：1995-11-01 00:00:00
