The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation.


UNLABELLED:One-lung ventilation (OLV) induces an increase in pulmonary shunt sometimes associated with a decrease in PaO2 despite ventilation with 100% oxygen. PaO2 improvement has been reported in one-lung ventilated animals receiving IV almitrine, a pulmonary vasoconstrictor. We evaluated the ability of almitrine to prevent a decrease in PaO2 during OLV. Patients without pulmonary hypertension undergoing OLV for lung surgery were randomly assigned to receive either placebo (Group P, n = 8) or almitrine infusion at a rate of 8 microg x kg(-1) x min(-1) (Group A, n = 8) from the start of OLV. Gasometric and hemodynamic values were recorded with the patient in the lateral decubitus position during two-lung ventilation and at 10-min intervals during OLV over a 30-min period (OLV-10, OLV-20, OLV-30). Compared with the values found during two-lung ventilation (434 +/- 22 mm Hg in Group P and 426 +/- 23 mm Hg in Group A), PaO2 decreased at OLV-10 (305 +/- 46 mm Hg), OLV-20 (203 +/- 20 mm Hg), and OLV-30 (178 +/- 18 mm Hg) in Group P (P < 0.05) and at OLV-20 (354 +/- 25 mm Hg) and OLV-30 (325 +/- 17 mm Hg) in Group A (P < 0.05). PaO2 values differed between the groups at OLV-20 and OLV-30 (P < 0.05). Pulmonary artery pressure and cardiac output did not change. In conclusion, 8 microg x kg(-1) x min(-1) IV almitrine prevents and limits the OLV-induced decrease in PaO2 without causing any hemodynamic modification. IMPLICATIONS:Eight microg x kg(-1) x min(-1) IV almitrine limits one-lung ventilation-induced decrease in PaO2 without causing any hemodynamic modification in patients without pulmonary hypertension.


Anesth Analg


Anesthesia and analgesia


Moutafis M,Dalibon N,Liu N,Kuhlman G,Fischler M




Has Abstract


2002-04-01 00:00:00


830-4, table of contents










  • Comparison of Supraglottic Airway Devices With Endotracheal Intubation in Low-Risk Patients for Cesarean Delivery: Systematic Review and Meta-analysis.

    abstract:BACKGROUND:The safety and adverse event rate of supraglottic airway (SGA) devices for cesarean delivery (CD) is poorly characterized. The primary aims of this review were to determine whether the first-pass success was higher and time to insertion for SGA was faster than endotracheal intubation for elective CD. The sec...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析


    authors: White LD,Thang C,Hodsdon A,Melhuish TM,Barron FA,Godsall MG,Vlok R

    更新日期:2020-10-01 00:00:00

  • Lateral approach to the sciatic nerve in the popliteal fossa.

    abstract:UNLABELLED:We describe a modification of the sciatic nerve (SN) block in the popliteal fossa through the lateral approach. After a brief anatomic study using previously reported landmarks, we propose a new needle orientation associated with a double injection technique after identification of the tibial and the common ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Zetlaoui PJ,Bouaziz H

    更新日期:1998-07-01 00:00:00

  • A laboratory evaluation of an auditory display designed to enhance intraoperative monitoring.

    abstract:UNLABELLED:Encouraged by the popularity of the pulse oximeter pulse-tone, we developed and tested an auditory display of six physiologic variables. The display consisted of a cardiovascular sound triggered by every heartbeat (conveying heart rate) and a respiratory sound triggered by every breath (conveying respiratory...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Loeb RG,Fitch WT

    更新日期:2002-02-01 00:00:00

  • Postoperative analgesia after spinal blockade in infants and children undergoing cardiac surgery.

    abstract::The aim of this prospective, randomized, controlled clinical trial was to define the opioid analgesic requirement after a remifentanil (REMI)-based anesthetic with spinal anesthetic blockade (SAB+REMI) or without (REMI) spinal blockade for open-heart surgery in children. We enrolled 45 patients who were candidates for...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hammer GB,Ramamoorthy C,Cao H,Williams GD,Boltz MG,Kamra K,Drover DR

    更新日期:2005-05-01 00:00:00

  • Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine.

    abstract:BACKGROUND:Postoperative sore throat (POST) is a common complication after endotracheal intubation. We compared the effectiveness on POST of spraying the endotracheal tube (ETT) cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. METHODS:Three hundred seventy-two patients were randomly allocated into...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Hung NK,Wu CT,Chan SM,Lu CH,Huang YS,Yeh CC,Lee MS,Cherng CH

    更新日期:2010-10-01 00:00:00

  • New Strategies to Expand and Optimize Heart Donor Pool: Ex Vivo Heart Perfusion and Donation After Circulatory Death: A Review of Current Research and Future Trends.

    abstract::Heart transplantation remains the definitive management for end-stage heart failure refractory to medical therapy. While heart transplantation cases are increasing annually worldwide, there remains a deficiency in organ availability with significant patient mortality while on the waiting list. Attempts have therefore ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Beuth J,Falter F,Pinto Ribeiro RV,Badiwala M,Meineri M

    更新日期:2019-03-01 00:00:00

  • Postoperative ventilatory failure in an obese, myopathic woman with periodic somnolence: A case report.

    abstract::An obese woman with periodic sommolence developed postoperative ventilatory problems following an uncomplicated cholecystectomy. A severe myopathic process involving the respiratory muscles was found at necropsy. A brother, who died a week later, had myotonic dystrophy. ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Tsueda K,Shibutani K,Lefkowitz M

    更新日期:1975-07-01 00:00:00

  • The sevoflurane washout profile of seven recent anesthesia workstations for malignant hyperthermia-susceptible adults and infants: a bench test study.

    abstract:BACKGROUND:Preoperative flushing of an anesthesia workstation is an alternative for preparation of the anesthesia workstation before use in malignant hyperthermia-susceptible patients (MHS). We studied in vitro, using a test lung, the washout profile of sevoflurane in 7 recent workstations during adult and, for the fir...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Cottron N,Larcher C,Sommet A,Fesseau R,Alacoque X,Minville V,Fourcade O,Kern D

    更新日期:2014-07-01 00:00:00

  • The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery.

    abstract::The common adverse effects of traditional nonsteroidal antiinflammatory drugs on renal function include reductions in renal blood flow, glomerular filtration rate, and sodium and potassium excretion, mainly via inhibition of renal cyclooxygenase. We designed the present study to determine the effects of IV paracetamol...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Koppert W,Frötsch K,Huzurudin N,Böswald W,Griessinger N,Weisbach V,Schmieder RE,Schüttler J

    更新日期:2006-11-01 00:00:00

  • Emergency tracheal intubation: complications associated with repeated laryngoscopic attempts.

    abstract::Repeated conventional tracheal intubation attempts may contribute to patient morbidity. Critically-ill patients (n = 2833) suffering from cardiovascular, pulmonary, metabolic, neurologic, or trauma-related deterioration were entered into an emergency intubation quality improvement database. This practice analysis was ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Mort TC

    更新日期:2004-08-01 00:00:00

  • In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity.

    abstract:BACKGROUND:Animal models show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, bupivacaine and ropivacaine. We investigated the hypotheses that these ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Lirk P,Haller I,Colvin HP,Lang L,Tomaselli B,Klimaschewski L,Gerner P

    更新日期:2008-05-01 00:00:00

  • Influence and relative sensitivities of 50-Hz and 100-Hz tetanic stimuli on subsequent tetanic fade ratios in patients receiving vecuronium.

    abstract::We studied the possible effects of repetitive (1-min interval) 50- and 100-Hz tetanic stimuli on 50-Hz and 100-Hz tetanic fade ratios (RF50HZ and RF100HZ). We also evaluated the sensitivity of the recorded responses to these two tests to assess residual neuromuscular block (isometric adductor pollicis mechanical activ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baurain MJ,Hoton F,Dernovoi BS,d'Hollander AA

    更新日期:1996-01-01 00:00:00

  • Capnography accurately detects apnea during monitored anesthesia care.

    abstract::Apnea and airway obstruction are common during monitored anesthesia care (MAC). Because their early detection is essential, we sought to measure the efficacy of capnography as an indicator of apnea during MAC at a variety of oxygen flow rates compared with thoracic impedance. Anesthesia care providers using standard A...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Soto RG,Fu ES,Vila H Jr,Miguel RV

    更新日期:2004-08-01 00:00:00

  • A comparison of two epidural alpha 2-agonists, guanfacine and clonidine, in regard to duration of antinociception, and ventilatory and hemodynamic effects in goats.

    abstract::Epidural clonidine produces analgesia in humans with acute and chronic pain. Its use is limited because of short-lasting analgesia, hemodynamic depression, sedation, and respiratory depression. Intrathecal guanfacine has a longer duration of action than intrathecal clonidine. The present study compares these two drugs...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Smith BD,Baudendistel LJ,Gibbons JJ,Schweiss JF

    更新日期:1992-05-01 00:00:00

  • The division of the sciatic nerve in the popliteal fossa: anatomical implications for popliteal nerve blockade.

    abstract:UNLABELLED:The sciatic nerve (SN) originates from the L4-S3 roots in the form of two nerve trunks: the tibial nerve (TN) and the common peroneal nerve (CPN). The TN and CPN are encompassed by a single epineural sheath and eventually separate (divide) in the popliteal fossa. This division of the SN occurs at a variable ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Vloka JD,Hadzić A,April E,Thys DM

    更新日期:2001-01-01 00:00:00

  • Time required for oral ranitidine to decrease gastric fluid acidity.

    abstract::This study documented gastric fluid acidity in ambulatory surgical patients 30-120 min after they had taken a 300-mg tablet of ranitidine, as changes specific to this relatively brief dose-to-sampling interval previously had not been delineated. At 20-120 min before outpatient surgery, ranitidine was given with 15 mL ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Jacobs BR,Swift CA,Dubow HD,Kosarussavadi B,McGoldrick K,O'Connor TZ,Silverman DG

    更新日期:1991-12-01 00:00:00

  • Clinical and metabolic responses to different types of premedication.

    abstract::Clinical and metabolic responses to three types of premedication were studied in ASA physical status I patients given any one of the following: (a) 0.5 mg of atropine and 50 mg of meperidine given intramuscularly plus an oral placebo tablet (n = 14), (b) 10 mg of oral diazepam and an intramuscular placebo (2 mL NaCl, ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kirvelä OA,Kanto JH

    更新日期:1991-07-01 00:00:00

  • The additive antinociceptive interaction between WIN 55,212-2, a cannabinoid agonist, and ketorolac.

    abstract::Combinations of nonsteroidal antiinflammatory drugs (NSAIDs) and opioids are widespread in the management of pain, allowing better analgesia with reduced side effects. Cannabinoids are promising analgesic drugs that have pharmacological properties similar to those of opioids. However, the beneficial effects of cannabi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Ulugöl A,Ozyigit F,Yesilyurt O,Dogrul A

    更新日期:2006-02-01 00:00:00

  • Sedation-analgesia with propofol and remifentanil: concentrations required to avoid gag reflex in upper gastrointestinal endoscopy.

    abstract:BACKGROUND:The purpose of this study was to identify optimal target propofol and remifentanil concentrations to avoid a gag reflex in response to insertion of an upper gastrointestinal endoscope. METHODS:Patients presenting for endoscopy received target-controlled infusions (TCI) of both propofol and remifentanil for ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验


    authors: Borrat X,Valencia JF,Magrans R,Gimenez-Mila M,Mellado R,Sendino O,Perez M,Nunez M,Jospin M,Jensen EW,Troconiz I,Gambus PL

    更新日期:2015-07-01 00:00:00

  • Comparison of the fascia iliaca compartment block with the 3-in-1 block in children.

    abstract::A new single injection procedure, the fascia iliaca compartment block, is described for blocking the femoral, lateral cutaneous, and obturator nerves. The technique consists of injecting a local anesthetic immediately behind the fascia iliaca at the union of the lateral with the two medial thirds of the inguinal ligam...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Dalens B,Vanneuville G,Tanguy A

    更新日期:1989-12-01 00:00:00

  • Influencing Anesthesia Provider Behavior Using Anesthesia Information Management System Data for Near Real-Time Alerts and Post Hoc Reports.

    abstract::In this review article, we address issues related to using data from anesthesia information management systems (AIMS) to deliver near real-time alerts via AIMS workstation popups and/or alphanumeric pagers and post hoc reports via e-mail. We focus on reports and alerts for influencing the behavior of anesthesia provid...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审


    authors: Epstein RH,Dexter F,Patel N

    更新日期:2015-09-01 00:00:00

  • Fast-tracking after outpatient laparoscopy: reasons for failure after propofol, sevoflurane, and desflurane anesthesia.

    abstract:IMPLICATIONS:In this study, although 41%-94% of the patients were fast-track eligible after laparoscopic surgery, only 35%-53% of the patients actually bypassed the postanesthesia care unit (PACU) because of anesthetic-related factors and surgical complications. Residual sedation was the most common anesthetic-related ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Coloma M,Zhou T,White PF,Markowitz SD,Forestner JE

    更新日期:2001-07-01 00:00:00

  • Transesophageal echocardiography in myocardial revascularization: I. Accuracy of intraoperative real-time interpretation.

    abstract::Transesophageal echocardiography (TEE) is increasingly used intraoperatively as a monitor of ventricular function and volume. Despite its increasing use, whether data from TEE monitoring can be interpreted accurately on-line in real-time is unknown. We studied the performance of five community-based, full-time cardiac...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Bergquist BD,Leung JM,Bellows WH

    更新日期:1996-06-01 00:00:00

  • The discriminant power of simultaneous monitoring of spontaneous electroencephalogram and evoked potentials as a predictor of different clinical states of general anesthesia.

    abstract::Spontaneous or evoked electrical brain activity is increasingly used to monitor general anesthesia. Previous studies investigated the variables from spontaneous electroencephalogram (EEG), acoustic (AEP), or somatosensory evoked potentials (SSEP). But, by monitoring them separately, the available information from simu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究


    authors: Jeleazcov C,Schneider G,Daunderer M,Scheller B,Schüttler J,Schwilden H

    更新日期:2006-10-01 00:00:00

  • The use and effectiveness of electrocardiographic telemetry monitoring in a community hospital general care setting.

    abstract:UNLABELLED:The purpose of this study was to determine if rates of telemetry events differ between patients whose monitoring is appropriately "indicated" versus "not indicated" by systematically applying rigorous criteria for appropriateness of electrocardiogram (ECG) telemetry usage. We performed a retrospective cohort...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Curry JP,Hanson CW 3rd,Russell MW,Hanna C,Devine G,Ochroch EA

    更新日期:2003-11-01 00:00:00

  • Balloon versus conventional laryngoscopy: a comparison of laryngoscopic findings and intubation difficulty.

    abstract::We compared laryngeal aperture (LA) exposure and endotracheal intubation difficulty scale (IDS) scores between balloon-assisted and conventional laryngoscopy. Thirty-two anesthetized and paralyzed elective surgery patients underwent laryngoscopy with a standard number 4 and a modified number 4 curved blade carrying a ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章


    authors: Mentzelopoulos SD,Romana CN,Corolanoglou DS,Tzoufi MJ,Karamichali EA

    更新日期:2000-12-01 00:00:00

  • Cerebral metabolism assessed with microdialysis in uncontrolled hemorrhagic shock after penetrating liver trauma.

    abstract::In a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects of fluid resuscitation versus arginine vasopressin (AVP) combined with hypertonic-hyperoncotic hydroxyethyl starch solution (HHS) on cerebral perfusion pressure (CPP) and on cerebral metabolism using intracerebral microdialysis. Sixteen ane...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Meybohm P,Cavus E,Bein B,Steinfath M,Brand PA,Scholz J,Dörges V

    更新日期:2006-10-01 00:00:00

  • Gabapentin enhances the analgesic effect of morphine in healthy volunteers.

    abstract:UNLABELLED:The most effective group of drugs for the treatment of severe pain is opioid analgesics. Their use, however, is limited by decreased effects in neuropathic and chronic pain as a result of increased pain and development of tolerance. Gabapentin (GBP) is effective in both experimental models of chronic pain an...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Eckhardt K,Ammon S,Hofmann U,Riebe A,Gugeler N,Mikus G

    更新日期:2000-07-01 00:00:00

  • Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw.

    abstract::This study evaluated the role of nitric oxide (NO) in spinal cord nociceptive transmission during peripheral inflammation evoked by formalin injection into the rat paw, using N omega-nitro-L-arginine (N-Arg), an NO synthase inhibitor. Male rats were prepared with intrathecal (IT) catheters. To quantify the formalin re...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Yamamoto T,Shimoyama N,Mizuguchi T

    更新日期:1993-11-01 00:00:00

  • Use of ProSeal laryngeal mask airway in 2114 adult patients: a prospective study.

    abstract:BACKGROUND:There have been numerous studies published on the ProSeal laryngeal mask airway (PLMA). However, few have investigated its utility in a large practice setting. We sought to gather comprehensive data about the characteristics, efficacy, and safety of its use by a representative group of anesthesiologists work...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章


    authors: Goldmann K,Hechtfischer C,Malik A,Kussin A,Freisburger C

    更新日期:2008-12-01 00:00:00