Abstract:
BACKGROUND:Meconium aspiration syndrome is a disease in near term infants which requires invasive techniques to decrease mortality. Lavage of the tracheobronchial tree with exogenous surfactant has been shown to be effective in animal studies. We studied the effectiveness of this technique in newborn infants and compared them with a historical control group. PATIENTS AND METHODS:From 1987 to 1998, we treated 18 neonates with meconium aspiration syndrome. In 11 babies a lavage with bovine derived diluted surfactant was carried out immediately after admission. In 7 infants of the control group only the meconium was suctioned or a lavage with saline performed. There were no differences between both groups concerning other therapeutic interventions like high frequency ventilation or inhalative NO. The control group contained significantly more outborn patients compared with the lavage group. Criteria of effectiveness were change in oxygenation index (OI), duration of mechanical ventilation and oxygen supplementation greater than 30 %. In addition, the two groups were compared for incidence of death, need for ECMO, and air leaks. RESULTS:One infant of the lavage group died, one had to be transferred to ECMO (no significant difference). There was a significant decrease in OI after surfactant lavage from 22 at admission to 5.1 one day later (p=0.007), whereas in the control group, OI did not change significantly over time (15.8 to 11.4). There were no differences in the duration of mechanical ventilation or oxygen supplementation. CONCLUSIONS:In our study, lavage with exogenous surfactant had only a short-term effect in decreasing OI in neonates with meconium aspiration. Larger numbers of patients need to be investigated to demonstrate an improvement in long-term outcome.
journal_name
Z Geburtshilfe Neonatoljournal_title
Zeitschrift fur Geburtshilfe und Neonatologieauthors
Schlössser RL,Veldman A,Fischer D,Allendorf A,von Loewenich Vdoi
10.1055/s-2002-20945subject
Has Abstractpub_date
2002-01-01 00:00:00pages
15-8issue
1eissn
0948-2393issn
1439-1651journal_volume
206pub_type
杂志文章abstract::Fetomaternal hemorrhage (FMH) is usually detected by either the Kleihauer-Betke (KB) test or by 2 cytometry, the latter of which represents the gold standard of FMH diagnosis today. But what do we do when neither method is available? We present two cases of suspected FMH due to their characteristic signs and symptoms ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-1041-3443
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abstract:BACKGROUND:In 25 % of patients who develope gestosis a Hemolysis- Elevated- Liver-enzymes-and- Low- Platelet-count-Syndrome (HELLP-Syndrome) may occur, which is characterized by activation of the coagulation mechanism and bone marrow alterations. Besides this therapeutical steroid application and an elevated age of pri...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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更新日期:1997-07-01 00:00:00
abstract::Careful analysis of current adjudication reveals increasing demand of adequate record-keeping as well as meticulously documented informed consent forms regarding all aspects of medicine. Although standardized informed consent forms or explicit guidelines for obtaining procedural consent already exist in surgical disci...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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abstract::In spite of the continuous progress in prenatal care, 1 out of 10 babies is born too early--tendency rising worldwide. As a consequence of the heterogeneous aetiology of preterm birth, there is still no single and efficient interventional therapy. Cerclage is one option for pregnancies with cervical insufficiency, whe...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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abstract:BACKGROUND:There are convincing data from neonatal studies that the base excess (BE, mmol/L) measured in capillary or cord blood offers special diagnostic and prognostic power in the new-born compromised by hypoxia. For computation of BE the hemoglobin concentration (Hb, %), the oxygen saturation (%) and the distributi...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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更新日期:2005-06-01 00:00:00
abstract::Chorangiomas of the placenta, benign tumors of chorionic tissue, are a rare placental cause of adverse fetal and maternal outcomes. We describe the case of a large placental chorangioma leading to polyhydramnios as well as consecutive preterm birth and high output cardiac failure of the newborn. Derived from a literat...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-2000-10189
更新日期:2000-01-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2004-818961
更新日期:2004-04-01 00:00:00
abstract:INTRODUCTION:Computer analysing software is required for the assessment of CTGs because of the low sensitivity and high intra- and interobserver variability. The German Society of Gynaecology and Obstetrics advises the use of computer analysing CTG software. This study is aimed at evaluating the use of a new foetal ECG...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0028-1098718
更新日期:2008-12-01 00:00:00
abstract::Maternal thrombocytopenia is a frequent finding in pregnancy. The clinically important causes of maternal thrombocytopenia in pregnancy are gestational thrombocytopenia and autoimmune thrombocytopenia. We report a case of refractory idiopathic thrombocytopenic purpura by a 30-year-old pregnant woman, gravida 3, para 2...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 临床试验,杂志文章
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doi:10.1055/s-2001-14821
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更新日期:2018-10-01 00:00:00
abstract::Newly diagnosed cancer in pregnancy is an issue with increasing importance, because fulfilling the wish to have a child is shifted later in life. Tumour disease is diagnosed in around 0.1% of all pregnancies in Germany. Most common tumour entities involve the breast, the cervix and the hematopoietic system. As tumour ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0032-1309052
更新日期:2012-08-01 00:00:00
abstract::A few years ago recombinant human erythropoietin (rh-EPO) has been introduced for the prophylaxis of anaemia of prematurity. Aim of this controlled study was a cost-effectiveness analysis of the prophylaxis with rh-EPO versus sole transfusion with packed red blood cells. In the study group 33 infants (gestational age ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-12-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2003-40974
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Chorangiomas are regarded as hamartous lesions of the placenta which may complicate a pregnancy if they grow large. The etiology of these lesion is still unclear. We suspected a link between the development of chorangiomas and an increase of the expression of the angiogenic growth factor bfgf and angiopoieti...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2003-37838
更新日期:2003-01-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
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journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00