Abstract:
BACKGROUND:There are convincing data from neonatal studies that the base excess (BE, mmol/L) measured in capillary or cord blood offers special diagnostic and prognostic power in the new-born compromised by hypoxia. For computation of BE the hemoglobin concentration (Hb, %), the oxygen saturation (%) and the distribution of the fetal fluid compartments are necessary. Until now these three factors, which differ in the fetus when compared with adults, have not been taken into account using automatic blood gas equipment. This study therefore attempts to analyse and verify which BE will offer the best fit with the outcome conditions in the newborn. METHODS:Using a cohort of 7701 singletons delivered at term by the vaginal route in whom a blood gas analysis in cord blood together with Hb measurements were available and plausible, three BE values were computed: the ordinary BE (actual BE, according to Radiometer determinations), the BE corrected to the real oxygen saturation (BE,oxy) and the BE in the extracellular fluid compartment of the fetus (BE,ecff) using the algorithms of O. Siggaard-Andersen. Moreover, three different oxygen saturation curves for fetal Hb (HbF) were applied, namely those of Zander et al., Hellegers and Schruefer and Ruiz et al. (Severinghaus). The prognostic potential of the different BE values was analysed using a correlation with the APGAR-score after 1 min, the sum of the APGAR indices after 1 and 5 min, and additionally with the fetal heart frequency (FHF) of the last 30 min ante-partum quantified by a score electronically in a group of 342 fetuses. RESULTS:The median of the actual BE in umbilical artery blood amounted to -4.9 mmol/L. Correction to the real oxygen saturation of the blood sample leads to a median of -7.7 mmol/L. Using three different oxygen saturation curves and thus taking into account HbF reveals little influence on the numerical values of BE. However, application of the true distribution of fetal fluid compartments in the evaluation of BE (BE,ecff) leads to a significant reduction of the numerical value of BE (median = -3.2 mmol/L). Computational correction of BE using the real oxygen saturation (%) in each fetus leads to a important and highly significant increase of the correlation (r and rho) with the APGAR indices. The correlation with the FHF score also increased but failed to reach significance. CONCLUSIONS:Our data show that, in perinatal medicine, a computational correction of BE according to the real oxygen saturation of the blood sample is mandatory. An algorithm for HbF should be used. The BE in the extracellular fluid compartment does not fit to reality. The determination of the Hb concentration in the umbilical blood of each fetus is essential since its variability is higher than expected. In legal controversies the computational origin of BE should be documented and carefully regarded.
journal_name
Z Geburtshilfe Neonatoljournal_title
Zeitschrift fur Geburtshilfe und Neonatologieauthors
Roemer VMdoi
10.1055/s-2005-871217subject
Has Abstractpub_date
2005-06-01 00:00:00pages
81-9issue
3eissn
0948-2393issn
1439-1651journal_volume
209pub_type
临床试验,杂志文章abstract::Cardiac etiologies of hydrops fetalis have been a topic of concern due to challenging perinatal management. The common cardiac etiologies leading to hydrops fetalis include structural cardiac anomalies, cardiac dysrhythmias, cardiac tumors, cardiomyopathy and myocarditis. The mechanisms of cardiogenic hydrops fetalis ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0042-123825
更新日期:2017-04-01 00:00:00
abstract::Maternal thrombocytopenia is a frequent finding in pregnancy. The clinically important causes of maternal thrombocytopenia in pregnancy are gestational thrombocytopenia and autoimmune thrombocytopenia. We report a case of refractory idiopathic thrombocytopenic purpura by a 30-year-old pregnant woman, gravida 3, para 2...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::There have been repeated reports of a particularly severe course of disease on H1N1 infection in pregnant women. Complemented by a review of the current literature, this paper gives an overview of recommendations with respect to vaccination, therapy and prophylaxis in this risk group. ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1251973
更新日期:2010-04-01 00:00:00
abstract::Progressive systemic sclerosis is a connective tissue disease with inflammation and fibrosis. Pregnant women with progressive systemic sclerosis have an increased risk for preterm births and probably for small-for-date babies. We report the case of a 28-year-old II G O P suffering from progressive systemic sclerosis w...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2005-916247
更新日期:2005-12-01 00:00:00
abstract:INTRODUCTION:Therapeutic hypothermia (TH) improves the outcome in newborns with hypoxic-ischemic encephalopathy (HIE) and should be used in case of perinatal asphyxia and signs of moderate/severe HIE. MATERIAL/METHODS:Frequency of HIE and the application of TH were extracted from the neonatal survey, a registry that c...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-1164-7174
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of asthma severity and disease exacerbation on pregnancy outcomes. MATERIALS AND METHODS:Pregnancies were classified into 3 groups as mild (n=195), moderate (n=63), and severe (n=26) according to preconceptional asthma severity. Demographic features, clinical characteristics, and perin...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-1264-8207
更新日期:2020-10-14 00:00:00
abstract::Within a group of preeclamptic women we found severe histologic placental pathology with functional relevance when both the uteroplacental and fetoplacental flow velocity waveforms showed elevated resistance indices. These pathological findings were a reduced decidual area, infarction and villus maturation failures wi...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:A sufficient quality of data transfer from written patient records to electronic data processing is a precondition for a reasonable usage of perinatal data. However the quality of data transfer of the almost 200 characteristics routinely recorded at each delivery is largely unknown. MATERIALS AND METHODS:Th...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2006-931583
更新日期:2006-04-01 00:00:00
abstract::Late preterm births with a gestational age of 340/7-366/7 are physiologically, anatomically and metabolically immature and develop medical complications significantly more frequently, have a high morbidity and an elevated mortality. Consideration of this knowledge will in future require new strategies for obstretric, ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0031-1285834
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to analyse the accuracy of prenatal sonography in terminated pregnancies and the influence of factors like personnel and standard of technique and organisation on the quality of prenatal sonography for the detection of fetal anomalies. MATERIAL AND METHODS:The retrospective study inc...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2001-14821
更新日期:2001-03-01 00:00:00
abstract::We report on prenatal diagnosis of gastroschisis at 20th gestational week. In addition to gastroschisis intraabdominal intestinal stenosis was detected. As a consequence cesarean section was planned close to term. Control examinations in the last trimester didn't confirm initial diagnosis so that the recommended mode ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::Noninvasive prenatal testing (NIPT) is a screening test for fetal chromosome disorders. Recent studies show an incidental detection of maternal malignancies in NIPT diagnostics, where the simultaneous presence of multiple aneuploidies is described as an NIPT "anomaly". In this case, the diagnosis of a maternal tumor d...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-0850-0650
更新日期:2019-06-01 00:00:00
abstract::Ante- and postpartum noninvasive 24-hour ambulatory blood pressure measurements were performed in 18 normotensive pregnants and 36 patients with mild (n = 16) or severe preeclampsia (n = 12) or HELLP-syndrome (n = 8). In contrast to normotensive pregnancy (n = 18) displaying a decline of systolic and diastolic blood p...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::An 28 years old women came on his 7. post partum day with an lower abdominal pain on the right hand side with the diagnosis of an unilateral rotating ovarian tumor. After computed tomography, ultrasound and laparoscopy the adnectomia dextra by laparotomy was performed. In the histology we find an ovarian vein thrombos...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:This study examines the recommendations of international guidelines on the use of antepartum and intrapartum cardiotocography. MATERIAL AND METHODS:The guidelines of Germany, Canada, UK, USA, Sri Lanka, Australia as well as FIGO have been compared. The recommendations on the use of cardiotocography were sepa...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0043-122945
更新日期:2018-04-01 00:00:00
abstract::Objective: Review of anonymous data of all stillbirths in all 19 obstetrical departments in Berlin from 2013-2014 with the goal to develop strategies for prevention of stillbirths (≥500 g birth weight). Results: There were a total of 401 stillbirths,178 after fetocide or pregnancy termination and 223 were spontaneous ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,多中心研究
doi:10.1055/s-0042-118094
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Intensive research has been conducted on the effects of toxic and trace elements on pregnancy. Previous studies indicated a possible relationship between placental levels of these elements and first-trimester abortion; however, their effects on the further gestational weeks are not clear. This study aimed to in...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-1263-1698
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Acupuncture as a non-evidence-based therapy modality is widely used in obstetrics prior to and during delivery. Thus far, only few studies investigated the impact of acupuncture on obstetric surveillance parameters like cardiotocography. The aim of this study was to control the effect of clearly-defined acup...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 临床试验,杂志文章
doi:10.1055/s-2003-43416
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:This study aimed to evaluate the incidence of knee pain or the intensification of knee-related problems during pregnancy. We hypothesised that the occurrence of knee problems correlates with an increase in body weight during pregnancy. METHODS:A total of 326 women (30(th)-40(th) week of pregnancy) were involve...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0034-1395536
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:During pregnancy about 30 grams of calcium are transferred to a full-term neonate. The enormous demand for calcium can be regulated by compensatory mechanisms in the maternal metabolism such as elevated steroid hormone levels, increased intestinal absorption of dietary calcium, and renal conservation, but als...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2006-951742
更新日期:2006-10-01 00:00:00
abstract::Introduction: It is estimated that after premature rupture of membranes (PROM) at term, 60% of all women go into labour within 48 h, 95% within 72 h. Often labour is induced after 24 h because the risk of maternal and neonatal infection rises. The majority of clinicians advise hospital care to allow monitoring and det...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0042-115035
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND AIM:We have previously analysed neonatal characteristics and duration of pregnancy in Germany based on data from the German Perinatal Survey of 1995-1997. Here we describe neonatal characteristics and duration of pregnancy based on the German Perinatal Survey of 2007-2011. MATERIAL AND METHODS:We had be...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0033-1361096
更新日期:2013-12-01 00:00:00
abstract::With regard to the question of the liability of a locum, the contractual general conditions are important above all others for the locum. The false opinion of some physicians that one is not liable because one is on holiday - or at least was not concretely involved in the incident - can, from case to case, be misleadi...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/s-0031-1287859
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:The extent to which faulty medical treatment and defective apparatus are concomitant causes for the development of subpartal acidosis was investigated in a retrospective study. At the same time, the incidence of acidosis in the Lippe-Detmold Hospital, Department of Gynaecology and Obstetrics, its morbidity an...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2002-34962
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:In 25 % of patients who develope gestosis a Hemolysis- Elevated- Liver-enzymes-and- Low- Platelet-count-Syndrome (HELLP-Syndrome) may occur, which is characterized by activation of the coagulation mechanism and bone marrow alterations. Besides this therapeutical steroid application and an elevated age of pri...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2003-45172
更新日期:2003-11-01 00:00:00
abstract::The cesarean section rate and the associated complications are still rising in Germany. An important indication is term breech in singletons. Not significant data concerning a higher morbidity or mortality in vaginal breech birth indicate the cesarean but a deficit in education and experience. ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0032-1309052
更新日期:2012-08-01 00:00:00
abstract::A fetal epidural hematoma is a rare finding during the prenatal period, with different etiologies such as maternal trauma, infections, or maternal use of specific medications such as warfarin. Both ultrasonography and magnetic resonance imaging (MRI) have been used successfully to evaluate the fetal central nervous sy...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-0042-113001
更新日期:2016-12-01 00:00:00
abstract::Chorangiomas of the placenta, benign tumors of chorionic tissue, are a rare placental cause of adverse fetal and maternal outcomes. We describe the case of a large placental chorangioma leading to polyhydramnios as well as consecutive preterm birth and high output cardiac failure of the newborn. Derived from a literat...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章,评审
doi:10.1055/a-0903-3034
更新日期:2020-04-01 00:00:00
abstract::Ever since the first report on fetal magnetocardiography by Kariniemi in 1974 numerous studies have examined cardiac activity in healthy fetuses using this technique. Recently there has been an increase in reports on the identification of fetal pathological states, in particular in the diagnosis of fetal arrhythmias, ...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/s-2005-837799
更新日期:2005-02-01 00:00:00
abstract::Frühgeburtenrate in 6 Perinatalzentren in Baden-Württemberg – Potential zur Reduktion der Frühgeborenenzahl Sehr geehrte Damen und Herren,mit großem Interesse haben wir die Arbeit von Trotter et al. 1 gelesen und teilen die Auffassung, dass eine Vermeidung von Frühgeburten und eine Reduzierung der Frühgeburtenrate unb...
journal_title:Zeitschrift fur Geburtshilfe und Neonatologie
pub_type: 杂志文章
doi:10.1055/a-0950-6770
更新日期:2019-08-01 00:00:00