Effects of the endothelin receptor antagonist bosentan on cardiac performance during porcine endotoxin shock.

Abstract:

BACKGROUND:Cardiac dysfunction during septic shock is well described but the underlying mechanisms still remain to be resolved. This study was conducted to elucidate the involvement of endothelin in cardiac function during endotoxin shock by the use of endothelin receptor antagonism. METHODS:Anaesthetised and haemodynamically stable landrace pigs received the nonpeptide mixed endothelin receptor antagonist bosentan, two hours after onset of endotoxaemia (n=7). Cardiopulmonary vascular changes, including cardiac index, stroke work index, coronary artery blood flow, rate of change of left ventricular pressure (dp/dt), and arterial and coronary sinus plasma levels of endothelin-1-like immunoreactivity were compared to a control group only receiving endotoxin (n=7). RESULTS:Plasma endothelin-1-like immunoreactivity increased threefold in the control group. Bosentan effectively counteracted the endotoxin induced decrease in cardiac index. This was accompanied by a significant reduction of both right and left ventricular afterload. In addition, coronary artery blood flow increased and coronary vascular resistance decreased compared to controls. Dp/dt remained unaffected by endothelin receptor antagonism. A further increase in plasma endothelin-1-like immunoreactivity was seen in response to bosentan. CONCLUSION:These results indicate that the increased endothelin production during endotoxaemia contributes to a depressed cardiac performance and that endothelin receptor antagonism may counteract this development. Possible mechanisms for the improved cardiac performance include both a reduction of afterload and enhanced coronary blood flow.

authors

Wanecek M,Weitzberg E,Alving K,Rudehill A,Oldner A

doi

10.1034/j.1399-6576.2001.451015.x

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1262-70

issue

10

eissn

0001-5172

issn

1399-6576

pii

451015

journal_volume

45

pub_type

杂志文章
  • Propofol 2 mg/kg is superior to propofol 1 mg/kg for tracheal intubation in children during sevoflurane induction.

    abstract:BACKGROUND:Propofol has been used to facilitate tracheal intubation within a short time of sevoflurane induction without a muscle relaxant in children. We compared as the primary outcome the incidence of excellent intubating conditions after 8% sevoflurane and propofol 1 or 2 mg/kg. METHODS:One hundred and four patien...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2011.02423.x

    authors: Siddik-Sayyid SM,Taha SK,Aouad MT,Abdallah FW,Al Alami AA,Kanazi GE

    更新日期:2011-05-01 00:00:00

  • Influence of orientations of guidewire tip on the placement of subclavian venous catheters.

    abstract:BACKGROUND:The role of a J-type guidewire tip has been known to prevent vascular or cardiac wall damage. We hypothesized that the course of the guidewire may be influenced by the initial orientations of the J-type guidewire tip during the subclavian approach. The purpose of this study was to investigate the influence o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00758.x

    authors: Park HP,Jeon Y,Hwang JW,Han SH,Bahk JH,Oh YS

    更新日期:2005-11-01 00:00:00

  • Stimulating or conventional perineural catheters after hallux valgus repair: a double-blind, pharmaco-economic evaluation.

    abstract:BACKGROUND:We prospectively evaluated direct analgesia-related costs of continuous sciatic nerve block using either a stimulating or conventional catheter after hallux valgus repair. METHODS:The perineural catheter was inserted through a stimulating introducer either blindly (group Conventional, n= 38) or while stimul...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01101.x

    authors: Casati A,Fanelli G,Danelli G,Baciarello M,Ghisi D,Nobili F,Chelly JE

    更新日期:2006-11-01 00:00:00

  • Rectal diazepam compared to intramuscular pethidine/promethazine/chlorpromazine with regard to gastric contents in paediatric anaesthesia.

    abstract::Sixty children, aged 1-12 years, were investigated with regard to gastric pH and volume before general anaesthesia. Thirty children (group D) received diazepam 0.75 mg/kg b.w. rectally 1 h before anaesthesia. Thirty children (group L) received a "lytic cocktail" (pethidine 28 mg, promethazine 7 mg, chlorpromazine 7 mg...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1984.tb02139.x

    authors: Blom H,Schmidt JF,Rytlander M

    更新日期:1984-12-01 00:00:00

  • Anesthetic approach to postdural puncture headache in the peripartum period: An Israeli national survey.

    abstract:BACKGROUND:Accidental dural puncture frequency among pregnant women is about 1.5%, while approximately 60% of these women will suffer from post-dural puncture headache (PDPH) that may be debilitating. METHODS:Following IRB approval, we conducted a national survey of the lead anesthesiologist in 23 labor and delivery r...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13208

    authors: Ioscovich A,Giladi Y,Fuica RL,Weiniger CF,Orbach-Zinger S,Gozal Y,Shatalin D

    更新日期:2018-11-01 00:00:00

  • Metoclopramide reduces the induction dose of propofol.

    abstract:BACKGROUND:Metoclopramide has been shown to reduce the dose of thiopentone required for induction of anaesthesia. When propofol is used, there have been conflicting results with one small study showing a reduction in the anaesthetic dose and one study failing to demonstrate any effect. METHODS:Two groups of 30 patient...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1997.tb04676.x

    authors: Page VJ,Chhipa JH

    更新日期:1997-02-01 00:00:00

  • Extreme metabolic acidosis. Case report.

    abstract::A 42-year-old male patient, who suffered from insulin-dependent diabetes mellitus (IDDM) and intolerance of lactose, presented with extreme metabolic acidosis (lactic acidosis). On arrival, an arterial blood sample showed: pH 6.79, PO2 18.8 kPa, PCO2 0.9 kPa, base excess-33 mmol l-1, blood glucose 38 mmol l-1 and oeso...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1987.tb02620.x

    authors: Sjøgren P,Andersen LW

    更新日期:1987-08-01 00:00:00

  • Severe complications associated with epidural and spinal anaesthesias in Finland 1987-1993. A study based on patient insurance claims [see comment].

    abstract:BACKGROUND:The Patient Injury Act has been in effect in Finland since 1 May 1987. This legislation is a no-fault compensation scheme and implies that if a patient during the course of medical treatment suffers any injury as a result of that treatment he or she may file a claim to the Patient Insurance Association (PIA)...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04722.x

    authors: Aromaa U,Lahdensuu M,Cozanitis DA

    更新日期:1997-04-01 00:00:00

  • Comparison of the concentration-dependent effect of sevoflurane on the spinal H-reflex and the EEG in humans.

    abstract:BACKGROUND:It has been shown that spinal reflexes such as the H-reflex predict motor responses to painful stimuli better than cortical parameters derived from the EEG. The precise concentration-dependence of H-reflex suppression by anaesthetics, however, is not known. Here we investigated this concentration-response re...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1399-6576.2004.00372.x

    authors: Rehberg B,Bouillon T,Gruenewald M,Schneider J,Baars J,Urban BW,Kox WJ

    更新日期:2004-05-01 00:00:00

  • Pharmacokinetics of a 24-hour intravenous ketoprofen infusion in children.

    abstract:BACKGROUND:No pharmacokinetic data are available with respect to the plasma concentration of ketoprofen during intravenous infusion in children. METHODS:We present here the pharmacokinetics of ketoprofen after a 10-min intravenous infusion of 1 mg/kg followed by a 24-h infusion of 4 mg/kg in 18 children aged 7 months ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460213.x

    authors: Kokki H,Karvinen M,Jekunen A

    更新日期:2002-02-01 00:00:00

  • Characteristics of muscle nerve sympathetic activity during general anaesthesia in humans.

    abstract::General anaesthesia influences the cardiovascular system at different levels. To increase our knowledge of how sympathetic outflow is affected by anaesthetic interventions, we used direct microelectrode recordings of muscle sympathetic activity (MSA) in the peroneal nerve in 18 patients scheduled for ENT-surgery. Duri...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1992.tb03478.x

    authors: Sellgren J,Pontén J,Wallin BG

    更新日期:1992-05-01 00:00:00

  • The different responses of the hepatic arterial bed to hypovolaemia and to halothane anaesthesia.

    abstract::Ten dogs were subjected to a period of hypovolaemia (bleeding volume: 2% of body weight) and to a period of halothane anaesthesia (end-tidal halothane concentration: 1%). Mean arterial blood pressure decreased to 79% of control value during hypovolaemia and to 58% of control value during halothane anaesthesia. Mean to...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1977.tb01247.x

    authors: Andreen M,Irestedt L,Zetterström B

    更新日期:1977-01-01 00:00:00

  • Comparison of methohexital and pentobarbital for premedication in children.

    abstract::Thirty children scheduled for elective orchiopexy or herniotomy were consecutively assigned at random to premedication with methohexital 80 mg/ml, 20 mg/kg rectally, 15 min before transportation to the operating room, or pentobarbital 28 mg/ml, 7 mg/kg rectally, 45 min before transportation. The quality of premedicati...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1990.tb03127.x

    authors: Christensen PA,Balslev T,Hasselstrøm L

    更新日期:1990-08-01 00:00:00

  • Nitrous oxide activates the supraspinal pain inhibition system.

    abstract::The effects th groups the changes in CO and SV were due mainly to a reduced demand of oxygen transport and expected changes in sympatho-adrenergic tone rather than to myocardial depression. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1981.tb01697.x

    authors: Komatsu T,Shingu K,Tomemori N,Urabe N,Mori K

    更新日期:1981-12-01 00:00:00

  • An increased body mass index is no risk factor for postoperative nausea and vomiting. A systematic review and results of original data.

    abstract:BACKGROUND:An increased Body Mass Index (BMI) is almost always mentioned as a fundamental risk factor for postoperative nausea (PN), vomiting (PV) or both (PONV). However, multivariate analyses were unable to detect any correlation. Therefore, we asked whether an increased BMI is really a risk factor for PONV. METHODS...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,meta分析

    doi:

    authors: Kranke P,Apefel CC,Papenfuss T,Rauch S,Löbmann U,Rübsam B,Greim CA,Roewer N

    更新日期:2001-02-01 00:00:00

  • Effects of levosimendan in patients with left ventricular hypertrophy undergoing aortic valve replacement.

    abstract:BACKGROUND:Left ventricular hypertrophy is associated with adverse outcomes, including death, during cardiac surgery. This may be facilitated by an increased oxygen demand and diastolic dysfunction. Levosimendan augments haemodynamics without further oxygen consumption and improves echocardiographic indices of diastoli...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.12425

    authors: Juhl-Olsen P,Jakobsen CJ,Rasmussen LA,Bhavsar R,Klaaborg KE,Frederiksen CA,Sloth E

    更新日期:2015-01-01 00:00:00

  • Risk factors for failure to extend labor epidural analgesia to epidural anesthesia for Cesarean section.

    abstract:AIM:To identify parturients at risk of inability to extend labor epidural analgesia in whom alternative methods of anesthesia should be considered for Cesarean section (CS). METHODS:For 6 months, we prospectively studied women undergoing CS with a functioning epidural catheter in place from the delivery ward. All part...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01083.x

    authors: Orbach-Zinger S,Friedman L,Avramovich A,Ilgiaeva N,Orvieto R,Sulkes J,Eidelman LA

    更新日期:2006-08-01 00:00:00

  • Regional cerebral glucose metabolism during sevoflurane anaesthesia in healthy subjects studied with positron emission tomography.

    abstract:BACKGROUND:The precise mechanism by which sevoflurane exerts its effects in the human brain remains unknown. In the present study, we quantified the effects of sevoflurane on regional cerebral glucose metabolism (rGMR) in the human brain measured with positron emission tomography. METHODS:Eight volunteers underwent tw...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02208.x

    authors: Schlünzen L,Juul N,Hansen KV,Gjedde A,Cold GE

    更新日期:2010-05-01 00:00:00

  • The effect of perineural dexamethasone on duration of sciatic nerve blockade: a randomized, double-blind study.

    abstract:BACKGROUND:Major hindfoot and ankle surgery is associated with severe postoperative pain, which is effectively alleviated by combined sciatic and saphenous nerve blockade. Local anaesthetics with added dexamethasone consistently prolongs the duration of pain relief compared to local anaesthetics alone. However, whether...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.13054

    authors: Hauritz RW,Hannig KE,Henriksen CW,Børglum J,Bjørn S,Bendtsen TF

    更新日期:2018-04-01 00:00:00

  • Neuromuscular blockade induced by flunarizine alone and in combination with pancuronium, suxamethonium or neomycin: studies in isolated rat phrenic-hemidiaphragm preparations.

    abstract::The in vitro effects of flunarizine on indirectly- and directly-elicited contractions in rat phrenic-hemidiaphragm preparations were studied. The interactions of flunarizine with non-depolarizing and depolarizing neuromuscular blocking drugs (pancuronium and suxamethonium) and with an aminoglycoside antibiotic (neomyc...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1989.tb02971.x

    authors: del Pozo E,Baeyens JM

    更新日期:1989-10-01 00:00:00

  • Ondansetron does not prevent pruritus induced by low-dose intrathecal fentanyl.

    abstract:BACKGROUND:Addition of an opioid to low-dose spinal anesthesia with bupivacaine improves the quality and success of anesthesia. However, the intrathecal fentanyl-induced pruritus is as high as 75%. We hypothesized that after administration of 4 or 8 mg of prophylactic IV ondansetron, the incidence of pruritus induced b...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1399-6576.2003.00206.x

    authors: Korhonen AM,Valanne JV,Jokela RM,Ravaska P,Korttila K

    更新日期:2003-11-01 00:00:00

  • Patients' participation in and evaluation of a follow-up program following intensive care.

    abstract:BACKGROUND:Patients' difficulties following critical illness and the willingness of intensive care units (ICU) to take an expanded responsibility during the recovery period have led to the development of different follow-up programs. The aim of this study was to explore and describe patients' participation in and evalu...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2011.02474.x

    authors: Glimelius Petersson C,Bergbom I,Brodersen K,Ringdal M

    更新日期:2011-08-01 00:00:00

  • Comparison of the effect of ketamine added to bupivacaine and ropivacaine, on stress hormone levels and the duration of caudal analgesia.

    abstract:BACKGROUND:The aim of this study was to compare bupivacaine 0.25% and ropivacaine 0.2%, singly and in combination with ketamine, for caudal administration in children. Duration of analgesia, the need for other analgesics and the stress response were measured. METHODS:Eighty children were randomized into four groups of...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00806.x

    authors: Akbas M,Titiz TA,Ertugrul F,Akbas H,Melikoglu M

    更新日期:2005-11-01 00:00:00

  • Ketorolac or fentanyl continuous infusion for post-operative analgesia in children undergoing ureteroneocystostomy.

    abstract:BACKGROUND:children undergoing ureteroneocystostomy suffer from post-operative pain due to the surgical incision and bladder spasm. A single-shot caudal block is a common technique for paediatric analgesia, but a disadvantage is the limitation of a short duration in spite of the additives co-administered. A few clinica...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2010.02354.x

    authors: Jo YY,Hong JY,Choi EK,Kil HK

    更新日期:2011-01-01 00:00:00

  • Adjusting positive end-expiratory pressure and tidal volume in acute respiratory distress syndrome according to the pressure-volume curve.

    abstract:BACKGROUND:Management of acute respiratory distress syndrome (ARDS) patients implies the selection of the adequate ventilatory parameters, essentially PEEP and tidal volume (Vt), to prevent ventilator-induced lung injury. These parameters should be reset as the lung injury evolves. Among the different methods proposed ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2003.00011.x

    authors: Pestaña D,Hernández-Gancedo C,Royo C,Uña R,Villagrán MJ,Peña N,Criado A

    更新日期:2003-03-01 00:00:00

  • Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients.

    abstract:BACKGROUND:Postoperative cognitive dysfunction (POCD) is a common complication after cardiac and major non-cardiac surgery with general anaesthesia in the elderly. We hypothesized that the incidence of POCD would be less with regional anaesthesia rather than general. METHODS:We included patients aged over 60 years und...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1034/j.1399-6576.2003.00057.x

    authors: Rasmussen LS,Johnson T,Kuipers HM,Kristensen D,Siersma VD,Vila P,Jolles J,Papaioannou A,Abildstrom H,Silverstein JH,Bonal JA,Raeder J,Nielsen IK,Korttila K,Munoz L,Dodds C,Hanning CD,Moller JT,ISPOCD2(International St

    更新日期:2003-03-01 00:00:00

  • Postischaemic regional microvascular variations in the porcine renal cortex.

    abstract::Regional microcirculatory differences in the superficial renal cortex were studied before and during 4 h following 60 min of renal ischaemia in seven pigs under continuous intravenous chlormethiazole-pancuronium anaesthesia. Superficial renal cortical blood flow (Qsrc) was measured by laser Doppler flowmetry (LDF) in ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03332.x

    authors: Sandin R,Feuk U,Modig J

    更新日期:1991-08-01 00:00:00

  • An unusual case of massive gastric distension with catastrophic sequelae.

    abstract::We report a case of massive gastric distension presenting with abdominal pain, shock and lower limb ischaemia. At laparotomy, gastric distension was found to be secondary to gastric outflow obstruction compounded by gas formation from antacid ingestion. Both the aorta and inferior vena cava were directly compressed by...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2004.00552.x

    authors: Lewis S,Holbrook A,Hersch P

    更新日期:2005-01-01 00:00:00

  • Pretreatment with sufentanil reduces myoclonus after etomidate.

    abstract:BACKGROUND:Myoclonic movements are a common problem during the induction of general anesthesia with etomidate. We investigated the influence of pretreatment with the opioid sufentanil on the incidence of etomidate-induced myoclonus. METHODS:Forty female patients (ASA physical status I-III) were randomly assigned to re...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2003.00081.x

    authors: Hueter L,Schwarzkopf K,Simon M,Bredle D,Fritz H

    更新日期:2003-04-01 00:00:00

  • Intravenous ketoprofen and epidural sufentanil analgesia in children after combined spinal-epidural anaesthesia.

    abstract:BACKGROUND:Epidural opioid analgesia has become more popular for postoperative pain treatment in children. Epidural opioids are associated with adverse effects such as respiratory depression, excessive sedation, protracted vomiting, urinary retention and pruritus. Following minor surgery, ketoprofen has a synergistic e...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.1999.430715.x

    authors: Kokki H,Tuovinen K,Hendolin H

    更新日期:1999-08-01 00:00:00