Low levels of insulin-like growth factor-I in cerebrospinal fluid in children with autism.

Abstract:

:Autism is a behaviourally defined syndrome characterized by disturbances of social interaction and communication and restrictions of behaviour patterns and imagination. The pathogenesis of autism is unknown but it is suspected that a number of genetic factors may be involved. Neurotrophic factors such as insulin-like growth factor-I (IGF-I) play a role in early brain development. The aim of this study was to determine whether IGF-I levels might be associated with the development of autism. IGF-I levels were measured in the CSF of 11 children with autism (4 females, 7 males; mean age 3.8 years, SD 1.1) using a sensitive radioimmunoassay method and compared with levels in 11 control participants (6 females, 5 males; mean age 3.8 years). Levels of IGF-I in the CSF were statistically significantly lower in the children with autism than in the control children (p=0.03). IGF-I may play a role in pathogenetic mechanisms of autism and the role of neurotrophic factors in autism and other neurodevelopmental diseases should be studied further.

journal_name

Dev Med Child Neurol

authors

Vanhala R,Turpeinen U,Riikonen R

doi

10.1017/s0012162201001116

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

614-6

issue

9

eissn

0012-1622

issn

1469-8749

journal_volume

43

pub_type

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