Abstract:
:Individuals with Down syndrome (DS), a disorder of known genetic etiology (trisomy of chromosome 21), exhibit several types of structural brain abnormalities that are detectable pathologically and by MRI. In addition, in middle age, individuals with DS develop histological and, in some cases, clinical features of Alzheimer's disease (AD). Abnormalities in MRI scans of 50 adults with DS, 11 of whom had clinical dementia, are described and compared with those of 23 cognitively normal, healthy subjects who were matched for age, sex, and race. Qualitative visual analogue scale (VAS) ratings on MRI hard copies for all subjects and computer-aided volume measures for a subsample of subjects were carried out. On VAS, subjects with DS had larger lateral ventricles, a higher frequency of posterior fossa arachnoid cysts/megacisterna magna and fewer scans rated as normal compared with controls. Quantitatively, total brain and gray-matter volumes were reduced in DS, as were the volumes of the left hippocampus and amygdala; ventricle volumes were larger. Post hoc comparisons of subjects with DS with and without dementia revealed that on VAS the former had more generalized atrophy for age, mesial temporal shrinkage, and third ventricular enlargement. Similarly, total brain, left hippocampus, and left amygdala volumes were reduced quantitatively in subjects with DS with dementia, while ventricular volumes were increased.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Pearlson GD,Breiter SN,Aylward EH,Warren AC,Grygorcewicz M,Frangou S,Barta PE,Pulsifer MBsubject
Has Abstractpub_date
1998-05-01 00:00:00pages
326-34issue
5eissn
0012-1622issn
1469-8749journal_volume
40pub_type
杂志文章abstract::According to previous case reports, some congenital abnormalities (CAs) of the brain, such as microcephaly, are a result of intrauterine herpes simplex virus infection. A population-based case-control study was conducted to determine the risk of neural tube defects (NTDs) after maternal herpes labialis infection durin...
journal_title:Developmental medicine and child neurology
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doi:10.1017/S0012162206001411
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journal_title:Developmental medicine and child neurology
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1984.tb04478.x
更新日期:1984-08-01 00:00:00
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
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更新日期:1981-10-01 00:00:00
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journal_title:Developmental medicine and child neurology
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journal_title:Developmental medicine and child neurology
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
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journal_title:Developmental medicine and child neurology
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
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journal_title:Developmental medicine and child neurology
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journal_title:Developmental medicine and child neurology
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doi:10.1111/j.1469-8749.1981.tb02060.x
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journal_title:Developmental medicine and child neurology
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doi:10.1111/j.1469-8749.1992.tb11423.x
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abstract::A survey of the population of the Spina Bifida Service (107 patients) of Georgetown University Hospital, Washington, D.C., and of a control population in the same hospital revealed that, although situated in an ethnically heterogeneous area, Service patients with a history of neural-tube defects in siblings or family ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1975.tb03523.x
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更新日期:2017-04-01 00:00:00
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162299001358
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pub_type: 杂志文章
doi:10.1111/j.1469-8749.1989.tb08406.x
更新日期:1989-02-01 00:00:00
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doi:10.1111/j.1469-8749.2007.02017.x
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1985.tb04522.x
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journal_title:Developmental medicine and child neurology
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doi:10.1017/s0012162204000635
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
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更新日期:1987-08-01 00:00:00
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1991.tb14904.x
更新日期:1991-05-01 00:00:00
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00