Maternal herpes labialis in pregnancy and neural tube defects.

Abstract:

:According to previous case reports, some congenital abnormalities (CAs) of the brain, such as microcephaly, are a result of intrauterine herpes simplex virus infection. A population-based case-control study was conducted to determine the risk of neural tube defects (NTDs) after maternal herpes labialis infection during pregnancy. Data were taken from the Hungarian Case-Control Surveillance of Congenital Abnormalities from 1980 to 1996, which included 1202 children with NTDs and 21641 comparison children with CAs other than NTDs. The adjusted relative risks (odds ratio [OR]) for NTDs associated with maternal herpes labialis in the first trimester of pregnancy was OR 1.19 (95% confidence interval [CI] 0.68-2.06), and in the entire pregnancy was OR 0.94 (95% CI 0.61-1.44). Self-reported maternal herpes labialis during pregnancy was not associated with a substantially increased risk of NTDs in infants.

journal_name

Dev Med Child Neurol

authors

Nørgård B,Nørgaard M,Czeizel AE,Puhó E,Sørensen HT

doi

10.1017/S0012162206001411

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

674-6

issue

8

eissn

0012-1622

issn

1469-8749

pii

S0012162206001411

journal_volume

48

pub_type

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