Abstract:
:Cerebral palsy (CP) is a complex disorder and children frequently have multiple impairments. Dystonia is a particularly frustrating impairment that interferes with rehabilitation and function and is difficult to treat. Of the available treatments, deep brain stimulation (DBS) has emerged as an option with the potential for large effect size in a subgroup of children. While brain stimulation has been used in CP for more than 40 years, modern devices and targeting methods are improving both the safety and efficacy of the procedure. Successful use of DBS depends on appropriate selection of patients, identification of effective neuroanatomical targets in each patient, careful neurosurgical procedure, and detailed follow-up evaluation and programming. The use of functional neurosurgery for neuromodulation in CP remains a technology in its infancy, but improving experience and knowledge are likely to make this one of the safest and most effective interventions for children with moderate-to-severe motor disorders. This review summarizes the current procedures for patient and target selection, and surgical implantation of DBS electrodes for CP. The history of DBS and future directions when used in secondary dystonia are also examined. WHAT THIS PAPER ADDS: Selection of candidates for deep brain stimulation (DBS) requires understanding of dystonia in cerebral palsy . DBS could become a first-line treatment option in some children. :ESTIMULACIÓN CEREBRAL PROFUNDA PARA LA PARÁLISIS CEREBRAL: ¿DÓNDE ESTAMOS AHORA?: La parálisis cerebral (PC) es un trastorno complejo y los niños con frecuencia tienen discapacidades múltiples. La distonía es un deterioro particularmente frustrante que interfiere con la rehabilitación y la función y es difícil de tratar. De los tratamientos disponibles, la estimulación cerebral profunda (DBS, por sus siglas en inglés - deep brain stimulation) ha surgido como una opción con el potencial de un gran tamaño de efecto en un subgrupo de niños. Si bien la estimulación cerebral se ha utilizado en PC durante más de 40 años, los dispositivos modernos y los métodos de detección están mejorando tanto la seguridad como la eficacia del procedimiento. El uso exitoso de la DBS depende de la selección apropiada de los pacientes, la identificación de objetivos neuroanatómicos efectivos en cada paciente, el procedimiento neuroquirúrgico cuidadoso y la evaluación y programación de seguimiento detalladas. El uso de la neurocirugía funcional para la neuromodulación en la PC sigue siendo una tecnología en su infancia, pero es probable que la mejora de la experiencia y los conocimientos hagan de esta una de las intervenciones más seguras y efectivas para los niños con trastornos motores de moderados a graves. Esta revisión resume los procedimientos actuales para la selección de pacientes y objetivos, y la implantación quirúrgica de electrodos DBS para PC. La historia de DBS y las direcciones futuras cuando se utilizan en la distonía secundaria también se examinan. :ESTIMULAÇÃO CEREBRAL PROFUNDA PARA PARALISIA CEREBRAL: ONDE ESTAMOS AGORA?: Paralisia cerebral (PC) é uma desordem complexa e crianças frequentemente apresentam múltiplas deficiências. A distonia é uma deficiência particularmente frustrante que interfere com a reabilitação e função, e é difícil de tratar. Dentre dos tratamentos disponíveis, a estimulação cerebral profunda (ECP) emergiu como uma opção com potencial de grande tamanho de efeito em um subgrupo de crianças. Embora a estimulação cerebral seja usada em PC há mais de 40 anos, dispositivos modernos e métodos de identificação de áreas alvo tem melhorado tanto a segurança quanto a eficácia do procedimento. O uso bem sucedido da ECP depende da seleção apropriada dos pacientes, identificação dos alvos neuroanatômicos efetivos para cada paciente, procedimento neurocirúrgico cuidadoso, e avaliação e programação detalhadas no acompanhamento. O uso de neurocirurgia funcional para neuromodulação em PC ainda é uma tecnologia iniciante, mas a crescente experiência e conhecimento provavelmente farão dela uma das mais seguras e efetivas intervenções para crianças com transtornos motores de moderados a severos. Esta revisão sintetiza os procedimentos atuais para seleção de pacientes e alvos, e a implantação cirúrgica de eletrodos de ECP para PC. A história da ECP e direções futuras, quando usados em distonia secundária, também são examinados.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Sanger TDdoi
10.1111/dmcn.14295subject
Has Abstractpub_date
2020-01-01 00:00:00pages
28-33issue
1eissn
0012-1622issn
1469-8749journal_volume
62pub_type
杂志文章,评审abstract::This study examined whether children with hemiplegic cerebral palsy (CP) have anticipatory control of fingertip forces during lifts of familiar objects, and what type of practice (blocked or random) best enhances the retention of anticipatory control during lifts of novel objects. Eighteen children with hemiplegic CP ...
journal_title:Developmental medicine and child neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0012162203001397
更新日期:2003-11-01 00:00:00
abstract::Early epilepsy is known to worsen the developmental prognosis of young children with a congenital focal brain lesion, but its direct role is often very difficult to delineate from the other variables. This requires prolonged periods of follow-up with simultaneous serial electrophysiological and developmental assessmen...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2008.03162.x
更新日期:2008-11-01 00:00:00
abstract:AIM:The aim of the study was to develop an ecologically valid synthesis of the evidence underpinning interventions for children with speech, language, and communication needs (SLCN), integrating a range of different data sources. METHOD:Three sources of information were integrated: the Cochrane Review of interventions...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/dmcn.12630
更新日期:2015-03-01 00:00:00
abstract:AIM:To describe the incidence of term and preterm neonatal cerebral sinovenous thrombosis (CSVT) and identify perinatal risk factors. METHOD:This was a national capture-recapture calculation-corrected surveillance and nested case-control study. Infants born preterm and at term with magnetic resonance imaging-confirmed...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.14816
更新日期:2021-01-27 00:00:00
abstract::Normal selective voluntary motor control (SVMC) can be defined as the ability to perform isolated joint movement without using mass flexor/extensor patterns or undesired movement at other joints, such as mirroring. SVMC is an important determinant of function, yet a valid, reliable assessment tool is lacking. The Sele...
journal_title:Developmental medicine and child neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1469-8749.2008.03186.x
更新日期:2009-08-01 00:00:00
abstract::Gliomatosis cerebri is the unifying term used when diffuse glial infiltration occurs throughout the cerebral hemispheres. The very few cases reported in children have presented with intractable epilepsy, corticospinal tract deficits, unilateral tremor, headaches, and developmental delay. Antemortem diagnosis is diffic...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162201000214
更新日期:2001-02-01 00:00:00
abstract::AIM This prospective multicenter study assessed performance and changes over time, with and without surgical intervention, in the modified Timed Up and Go (mTUG) and One-Minute Walk tests (1MWT) in children with bilateral cerebral palsy (CP). Minimum clinically important differences (MCIDs) were established for these ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/dmcn.12325
更新日期:2014-05-01 00:00:00
abstract::Central ventilatory dysfunction (CVD) is a significant complication of myelodysplasia with Arnold-Chiari type II defect. The records of 616 patients with myelodysplasia were reviewed and CVD was documented in 35 cases (5.7 per cent): it was the single most common cause of death in this population. There was no signifi...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1989.tb04005.x
更新日期:1989-06-01 00:00:00
abstract::This study assessed stability of measurement of quality of life (QOL) and health-related quality of life (HRQOL) over the course of 1 year among 185 adolescents (mean age 16y, SD 1 y 9 mo) with cerebral palsy (CP). Participants were classified on the Gross Motor Function Classification System as level I (n=55), II (n=...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2008.03053.x
更新日期:2008-09-01 00:00:00
abstract:AIM:To assess the prevalence and risk factors for autism spectrum disorder (ASD) in epilepsy, and to better understand the relationship and comorbidity between these disorders. METHOD:PsychINFO and PubMed were searched for articles published in the past 15 years that examined the prevalence of ASD in individuals with ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/dmcn.13598
更新日期:2018-01-01 00:00:00
abstract::Outcome was studied of all children and adolescents with pseudoseizures without epilepsy, who were referred and treated as in-patients and/or day patients in the tertiary psychiatric ward at Birmingham Children's Hospital, UK between 1988 and 1994. Information was derived from case-note data. Freedom from seizures for...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162201000986
更新日期:2001-08-01 00:00:00
abstract::Botulinum toxin A (BTX-A) is increasingly being used in early management of spasticity in ambulant children with cerebral palsy (CP), with the aim of improving function, promoting muscle growth, and delaying the need for surgical intervention. However, there is a lack of evidence about the long-term outcome of BTX-A i...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1017/S0012162205001453
更新日期:2005-10-01 00:00:00
abstract::The aim of this study was to compare the linear growth of children with cerebral palsy (CP) with that of children without CP. The segmental lengths (humerus, ulna, femur, tibia, and spine), recumbent length, body weight, and bone age of 62 children with CP (age range 2.25 to 14 years, mean 7.13 years) were measured an...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162299001528
更新日期:1999-11-01 00:00:00
abstract::One-hundred-and-sixty-six children whose blood lead levels had previously been determined were assessed on a battery of psychometric tests. Blood lead levels ranged from 7 to 33 micrograms/100 ml, and the group performed within the average range on all tests of attainment and intelligence. There were significant assoc...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1981.tb02038.x
更新日期:1981-10-01 00:00:00
abstract::Two girls with concomitant Goldenhar syndrome (oculo-auriculovertebral spectrum disorder) and autistic disorder are described. One was diagnosed as having Goldenhar syndrome in the first few weeks of life and as having autistic disorder in her fifth year; the other was diagnosed as having Goldenhar syndrome when she w...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1992.tb11405.x
更新日期:1992-11-01 00:00:00
abstract::Cisapride was used to treat gastro-oesophageal reflux in seven children with neurodevelopmental disorders and in 15 children who were neurologically normal. 24-hour lower-oesophageal pH monitoring was carried out before and after treatment. The neurologically normal group had a statistically significant decrease after...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1990.tb08547.x
更新日期:1990-07-01 00:00:00
abstract::On follow-up at 12 years to assess the relationship between minor neurological dysfunction (MND) and primary nocturnal enuresis (NE), the frequency of NE was found to be significantly higher in children with MND (N = 167) than in those who were neurologically normal (N = 174). There was no relationship between NE and ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1991.tb14904.x
更新日期:1991-05-01 00:00:00
abstract::Using prospectively collected data from 13971 births enrolled in a large population-based cohort study (Avon Longitudinal Study of Parents and Children: ALSPAC), the prevalence of feeding difficulties at 4 weeks and 6 months of age in 33 children subsequently diagnosed with cerebral palsy (CP) were investigated. It wa...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1017/s0012162201001633
更新日期:2002-01-01 00:00:00
abstract:AIM:Mutations in the SLC16A2 gene have been implicated in Allan-Herndon-Dudley syndrome (AHDS), an X-linked learning disability* syndrome associated with thyroid function test (TFT) abnormalities. Delayed myelination is a non-specific finding in individuals with learning disability whose genetic basis is often uncertai...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.2009.03471.x
更新日期:2010-05-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the efficacy and effectiveness of exercise interventions that may improve postural control in children with cerebral palsy (CP). METHOD:A systematic review was performed using American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) and Preferred Reporting Items ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/dmcn.12660
更新日期:2015-06-01 00:00:00
abstract::A follow-up study was done of extremely low-birthweight infants (less than or equal to 1000g) born between 1976 and 1979, a period when aggressive intervention was not routine practice. The survival rate was 19 per cent. 44 of the 46 survivors were followed to a mean age of 6 1/2 years. By five years of age 23 of the ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1988.tb04748.x
更新日期:1988-04-01 00:00:00
abstract::This case series describes three children with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS), an inflammatory condition characterized by a relapsing-remitting disease course responsive to steroids. The patients (two males, age 3y and 13y; one female, age 14y) ...
journal_title:Developmental medicine and child neurology
pub_type:
doi:10.1111/dmcn.13997
更新日期:2019-04-01 00:00:00
abstract::Carpal tunnel syndrome is extremely rare in childhood and in almost all previously reported cases it has been secondary to some underlying condition. Three 13- to 14-year-old girls are described with idiopathic carpal tunnel syndrome, confirmed by EMG and relieved by surgical decompression. A noteworthy feature in chi...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1987.tb08826.x
更新日期:1987-12-01 00:00:00
abstract::Neural reuse is the process by which neural elements originally developed for one purpose are put to many different subsequent uses. In this brief review I will outline the role of neural reuse in the development of the brain. Special attention will be paid to elucidating and differentiating between two different mech...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/dmcn.13039
更新日期:2016-03-01 00:00:00
abstract::This literature review addressed four questions. (1) In which populations other than cerebral palsy (CP) has the Gross Motor Function Classification System (GMFCS) been applied? (2) In what types of study, and why was it used? (3) How was it modified to facilitate these applications? (4) What justifications and eviden...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/dmcn.13602
更新日期:2018-02-01 00:00:00
abstract::Short-term test-retest reliability of the 10-metre fast walk test (10mFWT) and 6-minute walk test (6MWT) was evaluated in 31 ambulatory children with cerebral palsy (CP), with subgroup analyses in Gross Motor Function Classification System (GMFCS) Levels I (n=9), II (n=8), and III (n=14). Sixteen females and 15 males ...
journal_title:Developmental medicine and child neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1469-8749.2008.02048.x
更新日期:2008-05-01 00:00:00
abstract::The authors studied MR images of the brain in 152 patients, aged 1 to 19 years (mean 3.3), who had spastic cerebral palsy (CP) and were attending two hospitals in Japan in 1993 and 1994. Eighty-one patients had diplegia, 45 had quadriplegia, and 26 had hemiplegia. Of patients with diplegia, 72 had periventricular leuk...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract:AIM:To briefly outline the strengths and limitations of cerebral palsy (CP) registers, and to report on findings of the Australian Cerebral Palsy Register (ACPR) pertaining to a population cohort of children with CP. METHOD:De-identified data were extracted from the ACPR for people with CP in birth years 1993 to 2006,...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/dmcn.13026
更新日期:2016-02-01 00:00:00
abstract::The authors used the Teller acuity cards to assess the visual acuity of 51 infants and children with Down syndrome aged between two months and 18 years. The success rate and test times were comparable to those reported for normally developing children. Even those subjects in the study who were free of ocular disorders...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1994.tb11895.x
更新日期:1994-07-01 00:00:00
abstract::Childhood brain development begins before birth, and obstetric management, tests, and technologies designed to diagnose and treat fetal conditions can have an impact on development. Preconception counseling for maternal diabetes and hypertension affect the risk of fetal congenital anomalies and growth restriction. Pat...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
doi:10.1111/dmcn.14160
更新日期:2019-09-01 00:00:00