Seizure risk in patients with attention-deficit-hyperactivity disorder treated with atomoxetine.

Abstract:

:The comorbidity of seizures, epilepsy, and attention-deficit-hyperactivity disorder (ADHD) prompted the examination of whether atomoxetine use for ADHD is associated with an increased risk of seizures. Seizures and seizure-related symptoms were reviewed from two independent Eli Lilly and Company databases: the atomoxetine clinical trials database and the atomoxetine postmarketing spontaneous adverse event database. Review of clinical trial data indicated that the crude incidence rates of seizure adverse events were between 0.1 and 0.2%, and were not significantly different between atomoxetine, placebo, and methylphenidate. Only 2% of the postmarketing spontaneous reports of seizure events were classified as having no clear contributing or confounding factors, and the reporting rate (8 per 100 000 patients exposed) was within the expected range of population-based incidence. Although children with ADHD are increasingly recognized as being at an elevated risk for seizures, treatment of ADHD symptoms with atomoxetine does not appear to elevate this risk further. The shared vulnerability between ADHD and seizure activity should be taken into account when making treatment decisions for populations of children with epilepsy and children with ADHD.

journal_name

Dev Med Child Neurol

authors

Wernicke JF,Holdridge KC,Jin L,Edison T,Zhang S,Bangs ME,Allen AJ,Ball S,Dunn D

doi

10.1111/j.1469-8749.2007.00498.x

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

498-502

issue

7

eissn

0012-1622

issn

1469-8749

pii

DMCN498

journal_volume

49

pub_type

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