Abstract：
:Epidemiological data, particularly concordance rates in twin pairs and in multiply affected families, provide strong evidence that both genetic and environmental influences are important in the development of the chronic intestinal inflammation characteristic of Crohn disease and ulcerative colitis. Furthermore, supplementary data now suggest that not only susceptibility, but also disease behavior and response to therapy may have a strong genetic influence. The model of disease susceptibility most pertinent to the inflammatory bowel diseases is that Crohn disease and ulcerative colitis are related polygenic disorders. Recently, this model has received strong support from the results of genome-wide scanning and candidate gene studies carried out in European, North American and Australian populations. In spite of all potential difficulties related to disease and ethnic heterogeneity, consistent replication of linkage has been found with distinct regions on chromosomes 16, 12, 6 (the major histocompatibility complex) and most recently chromosome 14. Whereas the linkages on chromosome 16 and 14 appear strongest in Crohn disease, the chromosome 12 locus appears most pertinent to ulcerative colitis, and the HLA region appears more pertinent in all forms of inflammatory bowel disease. The current challenge is to narrow these regions of linkage and identify the susceptibility genes within the regions. The task may be greatly benefited by the recent successful sequence data available from the human genome project. Compelling data have emerged to suggest genetic markers that may allow prediction of disease severity, and efficacy and tolerability of immuno-suppressants commonly used in inflammatory bowel disease.
journal_name
Acta Odontol Scandjournal_title
Acta odontologica Scandinavicaauthors
Satsangi Jdoi
10.1080/000163501750266800subject
Has Abstractpub_date
2001-06-01 00:00:00pages
187-92issue
3eissn
0001-6357issn
1502-3850journal_volume
59pub_type
杂志文章,评审abstract：OBJECTIVE:Local anesthetics are the most commonly used drugs in dentistry, with a wide range of effects, including antimicrobial activity. High antimicrobial effects have recently been reported on oral microbes from articaine hydrochloride, revealed by the minimum inhibitory concentration and minimal bactericidal conce...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350802443466
更新日期：2009-01-01 00:00:00
abstract：:An index for evaluation of dental wear based on Ryge's system comprising three satisfactory and two not acceptable categories was tested in two different age groups of individuals with brain damage. Group 1 consisted of 12 individuals, 3 women and 9 men, with a mean age of 34.5 years. Group 2 consisted of 13 individua...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016358709096359
更新日期：1987-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of storage duration on the tensile bond strength of acrylic and silicone-based denture base materials with liners either heat-cured or auto-cured. MATERIAL AND METHODS:The denture liners investigated were Vertex soft (acrylic-based, heat-cured), Coe soft (acrylic-based, auto-cured),...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350510019667
更新日期：2005-02-01 00:00:00
abstract：:The purpose was to study differences in the caries increment rate as influenced by various sugars. The trial involved almost complete substitution of sucrose (S) by fructose (F) or xylitol (X) during a period of 2 years. There were no significant initial differences as to caries status between the prospective sugar gr...
journal_title：Acta odontologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00016357608997711
更新日期：1976-01-01 00:00:00
abstract：:This randomized clinical trial was initiated to study the effect of two restorative procedures on the clinical quality and longevity of class-III resin restorations. The material consisted of 52 pairs of class-III restorations in the microfilled resin Silar completed with two modifications of the conventional acid-etc...
journal_title：Acta odontologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00016359309040575
更新日期：1993-08-01 00:00:00
abstract：:Sucking habits and their connection with family background was investigated in 3-year-old Finnish children. The association between sucking habits and malocclusion was also studied. The study was based on a survey with stratified randomized cluster sampling, confidential questionnaires, and clinical dental examination...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359309041144
更新日期：1993-02-01 00:00:00
abstract：:The seating of MOD composite inlays was determined before and after cementation with one of three cements of different viscosities. The seating was determined by measuring the axial discrepancy. Inlays were seated by strong finger pressure or by the ultrasonic insertion (USI) technique. The axial discrepancy of luted ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359409096376
更新日期：1994-02-01 00:00:00
abstract：:The enzyme beta-glucuronidase (E.C. 3.2.1.31.) has been studied in developing teeth and bone of Sprague-Dawley rats and Macaque monkeys (Macaca Irus) by means of histochemistry using naphthol-AS-BI-beta-D-glucuronide as substrate and hexazotized pararosanilin as coupling reagent. Since beta-glucuronidase is sensitive ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357509026357
更新日期：1975-01-01 00:00:00
abstract：OBJECTIVE:This study investigated the influence of preparation design on the marginal and internal gap and ceramic thickness of partial ceramic crowns (PCCs) fabricated with the CEREC 3 system. MATERIALS AND METHODS:Sixteen extracted human mandibular molars were prepared according to two different preparation designs ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2014.956145
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:To investigate the expression of Wnt3a, Wnt10b, β-catenin and DKK1 in the periodontal ligament (PDL) during orthodontic tooth movement (OTM) in rats. MATERIALS AND METHODS:Nickel-titanium closed-coil springs were used to deliver an initial 50 g mesial force to the left maxillary first molars in 30 rats. The ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2015.1090011
更新日期：2016-01-01 00:00:00
abstract：:Little information is available on the effect of miswak use on gingival microbiota. We assessed levels of 28 oral bacteria in subgingival plaque of adult Sudanese miswak (n = 38) and toothbrush users (n = 36) age range 20-53 years (mean 34.6 years) to study associations between these bacteria, oral hygiene method, and...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350310002784
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:To evaluate oral fluoride (F) retention after using fluoridated toothpastes, rinsing solutions and chewing sticks (Miswaks) in orthodontic patients with and without orthodontic appliances. MATERIAL AND METHODS:Nine orthodontic patients, with a mean age of 16 years, were included in a randomized, cross-over, ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章,随机对照试验
doi：10.3109/00016350903571723
更新日期：2010-07-01 00:00:00
abstract：:Fixed prosthodontic work ordered by general dental practitioners was examined through registrations made in commercial dental laboratories. A comparison was made with similar data from student files on fixed prosthodontic treatment at the University Clinic in Bergen, Norway, which is located in the same geographic are...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359009005880
更新日期：1990-08-01 00:00:00
abstract：IMPORTANCE AND OBJECTIVE:Reactive Oxygen Species (ROS) are oxygen-derived molecules that are unstable and highly reactive. They are important signaling mediators of biological processes. In contrast, excessive ROS generation, defective oxidant scavenging or both have been implicated in the pathogenesis of several condi...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章,评审
doi：10.3109/00016357.2014.954267
更新日期：2015-02-01 00:00:00
abstract：AIM:To evaluate if the kinematics of engine-driven instruments affect the root canal shape. METHOD:The systematic review was registered in PROSPERO (CRD 42017077043). A broad search was performed for articles published before 26 September 2018 in the electronic databases: pubmed, scopus, web of science and Lilacs usin...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016357.2019.1570331
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:Composite restorative materials represent one of the most important groups of materials in contemporary dental practice. However, their incomplete polymerization may lead to monomer-induced genotoxicity. The objective of this study was to evaluate the genotoxicity of three flowable (Filtek Supreme XT Flow, Te...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2012.734419
更新日期：2013-05-01 00:00:00
abstract：:The purpose of this study was to determine the sensitivity, specificity, positive and negative predictive values for Corah's Dental Anxiety Scale (DAS) and two modified versions of it (MDAS; MDAS/4). A questionnaire was mailed to a simple random sample of 1,190 25-year-old residents in the west of Norway in 1997. Half...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350050217091
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to investigate the presence of symptoms and signs of temporomandibular disorders (TMD) in patients with tinnitus and to evaluate the effect of TMD treatment on tinnitus in a long-term perspective in comparison with a control group of patients on a waiting list. MATERIAL AND METHODS:O...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350500377842
更新日期：2006-04-01 00:00:00
abstract：:Fluorescent microspheres (FM) were used to visualize and semi-quantify blood flow in the temporomandibular joint (TMJ) during experimental unilateral traumatic occlusion of the maxillary and mandibular molar teeth in 30 young rats. At different postoperative observation periods varying from 1 to 30 days FM were inject...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359309040580
更新日期：1993-10-01 00:00:00
abstract：:The aim of this epidemiological study was to examine associations between temporomandibular (TMD)-related problems and variables from three domains: (1) socio-economic attributes, (2) general health and health-related lifestyle, and (3) dental attitudes and behaviors. The overall response rate to a questionnaire maile...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350410001649
更新日期：2004-08-01 00:00:00
abstract：:Seventy-three children with submucous cleft palate (38 girls and 35 boys), mean age 8.2 years (range 7.7-9.5), were studied retrospectively from orthopantomograms. Dental abnormalities in permanent dentition were found in 26 patients (36%). Missing teeth, mainly lower 2nd premolars, upper lateral incisors, and upper 2...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350410006572
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:The objective of the study was to evaluate orofacial dysfunction in individuals with Prader-Willi syndrome (PWS) and compare it with a healthy reference group. METHODS AND MATERIALS:The Nordic Orofacial Test-Screening (NOT-S) protocol was used for evaluation of orofacial function in 45 (23 Male, 22 Female) i...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2011.568961
更新日期：2011-09-01 00:00:00
abstract：:Scanning electron microscopy was used to study the effect of cyclophosphamide (Cy) on molar development in 18 Sprague-Dawley rats from 15 to 48 days of age after birth. Doses of 30 mg/kg body weight of Cy dissolved in 1 ml 0.9% NaCl were given to the rats at 10 and 13 days of age. Eighteen control rats had injections ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359709115414
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:The aims of this study were to investigate the incidence and recovery of temporomandibular joint (TMJ) pain and dysfunction during a 1-year period, and to examine factors associated with TMJ signs and symptoms. MATERIAL AND METHODS:The study population comprised 371 dental students examined at the start of e...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350601083554
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:Previous results regarding human sex chromosome aneuploidies have shown that the X and Y chromosomes affect tooth size and morphology. This study looked for the effect of sex chromosome deficiency on permanent tooth crown heights. MATERIALS AND METHODS:The material, from the Finnish KVANTTI Research Project,...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2014.921327
更新日期：2014-11-01 00:00:00
abstract：:Four brands of endodontic paper points were subjected to tests for sterility, antibacterial activity, and suitability as vehicles for bacteriological sampling procedures. No brand showed growth in the sterility assay. One brand showed weak but reproducible antibacterial activity. Recovery of viable bacteria after abso...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016358509046492
更新日期：1985-05-01 00:00:00
abstract：:In this study, we examined the prevalence of specific (dental) phobia among a sample of the Icelandic population. In addition to dental anxiety we explored factors that could be related to dental anxiety. In the period 1972-73, a stratified sample of 1641 schoolchildren in Reykjavík was selected for a study on maloccl...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350310005844
更新日期：2003-10-01 00:00:00
abstract：:The frequency of temporomandibular disorders (TMDs) and radiologically observed abnormalities in the condyles of the temporomandibular joints (TMJs) of professional violin and viola players was investigated in 26 orchestra violinists/violists (VP group) and in their sex-, age-, and dentition-matched controls (C group)...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359509005951
更新日期：1995-04-01 00:00:00
abstract：OBJECTIVE:This cross-sectional study assessed the prevalence and severity of the enamel defects, known as Molar-Incisor Hypomineralization (MIH) and its relationship to dental caries. MATERIALS AND METHODS:A sample of 1157 schoolchildren (population based), aged 6-12 years, of the Araraquara city-Brazil, was evaluated...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2012.734412
更新日期：2013-05-01 00:00:00
abstract：:We assessed the effects of oral self-care on periodontal health indicators among adults with diabetes. The sample consisted of 120 dentate individuals, all of whom were regular patients at the Salo Regional Hospital Diabetes Clinic in southwest Finland. Clinical periodontal examination included identification of visib...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/000163501317153257
更新日期：2001-12-01 00:00:00
