Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells.

abstract：:Interleukin-13 (IL-13) induced a potent mitogenic response in IL-3-dependent TF-1 cells and DNA synthesis to a lesser extent in MO7E and FDC-P1 cells. IL-13 stimulation of these lines, like IL-4 and insulin-like growth factor-1 (IGF-1), resulted in tyrosine phosphorylation of a 170-kD substrate. The tyrosine-phosphory...

journal_title：Blood

authors： Wang LM,Michieli P,Lie WR,Liu F,Lee CC,Minty A,Sun XJ,Levine A,White MF,Pierce JH

更新日期：1995-12-01 00:00:00

abstract：:To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph(-) ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph(-) ALL patients using the registry data, particula...

journal_title：Blood

authors： Nishiwaki S,Inamoto Y,Sakamaki H,Kurokawa M,Iida H,Ogawa H,Fukuda T,Ozawa Y,Kobayashi N,Kasai M,Mori T,Iwato K,Yoshida T,Onizuka M,Kawa K,Morishima Y,Suzuki R,Atsuta Y,Miyamura K

更新日期：2010-11-18 00:00:00

abstract：:The syndrome of episodic angioedema and eosinophilia is characterized by cyclic edema, marked peripheral blood eosinophilia, and eosinophil degranulation in the dermis. Using a sensitive immunoenzymetric method, we measured serum interleukin (IL)-5 levels in four patients with this syndrome. We also determined the per...

journal_title：Blood

authors： Butterfield JH,Leiferman KM,Abrams J,Silver JE,Bower J,Gonchoroff N,Gleich GJ

更新日期：1992-02-01 00:00:00

abstract：:Although recent advances have enabled hematopoietic stem cells (HSCs) to be enriched to near purity, more information about their characteristics will improve our understanding of their development and stage-related functions. Here, using microarray technology, we identified endothelial cell-selective adhesion molecul...

journal_title：Blood

authors： Yokota T,Oritani K,Butz S,Kokame K,Kincade PW,Miyata T,Vestweber D,Kanakura Y

更新日期：2009-03-26 00:00:00

abstract：:Exposure of neutrophils to agents such as lipopolysaccharide, tumor necrosis factor-alpha (TNF-alpha), and the granulocyte-macrophage colony-stimulating factor causes a major upregulation of subsequent agonist-induced NADPH oxidase activation. This priming effect is a prerequisite for neutrophil-mediated tissue damage...

journal_title：Blood

authors： Kitchen E,Rossi AG,Condliffe AM,Haslett C,Chilvers ER

更新日期：1996-12-01 00:00:00

abstract：:Absorption of iron was studied with a double-isotope technique that allowed differentiation between "mucosal uptake," "mucosal transfer," and ultimate "retention" of iron. A physiologic dose of ferrous sulfate was administered to 25 healthy young adults, 40 active aged persons, and 20 patients with uncomplicated iron ...

journal_title：Blood

authors： Marx JJ

更新日期：1979-02-01 00:00:00

abstract：:An unusual group of human B-cell tumors with cellular features of chronic lymphocytic leukemia or lymphoplasmacytoid leukemia, together with high levels of a monoclonal IgG serum protein, has been investigated. Analysis of tumor-derived VH genes of neoplastic B lymphocytes was used to determine the clonal relationship...

journal_title：Blood

authors： Sahota SS,Garand R,Bataille R,Smith AJ,Stevenson FK

更新日期：1998-01-01 00:00:00

abstract：:The inv(16)(p13q22) and t(16;16)(p13;q22) cytogenetic abnormalities occur commonly in acute myeloid leukemia (AML), typically associated with French-American-British (FAB) AML-M4Eo subtype. Reverse transcriptase-polymerase chain reaction (RT-PCR) techniques have been recently developed to detect the presence of severa...

journal_title：Blood

authors： Viswanatha DS,Chen I,Liu PP,Slovak ML,Rankin C,Head DR,Willman CL

更新日期：1998-03-15 00:00:00

abstract：:A 2-yr-old black girl presented with a thalassemic clinical picture and was found to have nearly 100% fetal hemoglobin in her red cells. Pedigree analysis indicated that she was a heterozygote for the hereditary persistence of fetal hemoglobin gene and for a beta O-thalassemia gene. A brother, who also had nearly 100%...

journal_title：Blood

authors： Beutler E,Turner E,Kuhl W

更新日期：1981-06-01 00:00:00

abstract：:Both total metabolic tumor volume (TMTV), computed on baseline positron emission tomography (PET), and end of induction (EOI) PET are imaging biomarkers showing promise for early risk stratification in patients with high-tumor-burden follicular lymphoma. A model was built incorporating these 2 factors in 159 patients ...

journal_title：Blood

authors： Cottereau AS,Versari A,Luminari S,Dupuis J,Chartier L,Casasnovas RO,Berriolo-Riedinger A,Menga M,Haioun C,Tilly H,Tarantino V,Federico M,Salles G,Trotman J,Meignan M

更新日期：2018-05-31 00:00:00

abstract：:Over the past decade, extracellular nucleotides (such as ATP and UTP) have emerged as key immunomodulators. This family of molecules, already known for its key metabolic functions, has been the focus of intense investigation that has unambiguously shown its crucial role as mediators of cell-to-cell communication. More...

journal_title：Blood

authors： Rossi L,Salvestrini V,Ferrari D,Di Virgilio F,Lemoli RM

更新日期：2012-09-20 00:00:00

abstract：:Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-t...

journal_title：Blood

authors： Pendino F,Nguyen E,Jonassen I,Dysvik B,Azouz A,Lanotte M,Ségal-Bendirdjian E,Lillehaug JR

更新日期：2009-04-02 00:00:00

abstract：:The duration of immunodeficiency following marrow transplantation is not known. Questionnaires were used to study the infection rates in 72 patients surviving 20 to 30 years after marrow grafting. Furthermore, in 33 of the 72 patients and in 16 donors (siblings who originally donated the marrow) leukocyte subsets were...

journal_title：Blood

authors： Storek J,Joseph A,Espino G,Dawson MA,Douek DC,Sullivan KM,Flowers ME,Martin P,Mathioudakis G,Nash RA,Storb R,Appelbaum FR,Maloney DG

更新日期：2001-12-15 00:00:00

abstract：:C3H mice have higher average ploidy megakaryocytes than all other mouse strains tested, but the mode of inheritance of this anomaly is unknown. Therefore, to clarify the genetics of high ploidy megakaryocytes in C3H mice, we measured megakaryocyte DNA content from both male and female offspring from F1, as well as bac...

journal_title：Blood

authors： McDonald TP,Jackson CW

更新日期：1994-03-15 00:00:00

abstract：:This study includes 47 normal subjects and 25 hemophilia B patients without inhibitor(s), showing different factor IX coagulant activity and antigen levels. Genomic DNA, digested with various restriction endonucleases, was hybridized with two different factor IX probes, ie, the cDNA and the subgenomic probe for the in...

journal_title：Blood

authors： Hassan HJ,Orlando M,Leonardi A,Chelucci C,Guerriero R,Mannucci PM,Mariani G,Peschle C

更新日期：1985-02-01 00:00:00

abstract：:This study was designed to assess the presence of endogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) within adherent layers of human Dexter-type cultures and to investigate the effect on granulomonopoiesis of adding exogenous GM-CSF to the culture medium. The presence of GM-CSF was demonstrated using...

journal_title：Blood

authors： Charbord P,Tamayo E,Saeland S,Duvert V,Poulet J,Gown AM,Herve P

更新日期：1991-09-01 00:00:00

abstract：:The beta-globin locus control region (LCR) is a large DNA element that is required for high-level expression of beta-like globin genes from the endogenous mouse locus or in transgenic mice carrying the human beta-globin locus. The LCR encompasses 6 DNaseI hypersensitive sites (HSs) that bind transcription factors. The...

journal_title：Blood

authors： Hu X,Bulger M,Bender MA,Fields J,Groudine M,Fiering S

更新日期：2006-01-15 00:00:00

abstract：:Peripheral blood B cells in patients with paroxysmal nocturnal hemoglobinuria (PNH) comprise variable mixtures of normal B cells produced before the onset of disease and glycosylphosphatidylinositol (GPI)-deficient B cells derived from the PNH hematopoietic stem cell. In a detailed phenotypic analysis of 29 patients w...

journal_title：Blood

authors： Richards SJ,Morgan GJ,Hillmen P

更新日期：2000-11-15 00:00:00

abstract：:The expression and function of a glycoprotein Ib (GPIb) complex on human umbilical vein endothelial cells (HUVECs) is still a matter of controversy. We characterized HUVEC GPIb using viper venom proteins: alboaggregins A and B, echicetin, botrocetin, and echistatin. Echicetin is an antagonist, and alboaggregins act as...

journal_title：Blood

authors： Tan L,Kowalska MA,Romo GM,Lopez JA,Darzynkiewicz Z,Niewiarowski S

更新日期：1999-04-15 00:00:00

abstract：:The intestinal microbiota in allogeneic bone marrow transplant (allo-BMT) recipients modulates graft-versus-host disease (GVHD), a systemic inflammatory state initiated by donor T cells that leads to colitis, a key determinant of GVHD severity. Indole or indole derivatives produced by tryptophan metabolism in the inte...

journal_title：Blood

authors： Swimm A,Giver CR,DeFilipp Z,Rangaraju S,Sharma A,Ulezko Antonova A,Sonowal R,Capaldo C,Powell D,Qayed M,Kalman D,Waller EK

更新日期：2018-12-06 00:00:00

abstract：:Studying human antigen-specific memory B cells has been challenging because of low frequencies in peripheral blood, slow proliferation, and lack of antibody secretion. Therefore, most studies have relied on conversion of memory B cells into antibody-secreting cells by in vitro culture. To facilitate direct ex vivo iso...

journal_title：Blood

authors： Franz B,May KF Jr,Dranoff G,Wucherpfennig K

更新日期：2011-07-14 00:00:00

abstract：:Although thalidomide (Thal) was initially used to treat multiple myeloma (MM) because of its known antiangiogenic effects, the mechanism of its anti-MM activity is unclear. These studies demonstrate clinical activity of Thal against MM that is refractory to conventional therapy and delineate mechanisms of anti-tumor a...

journal_title：Blood

authors： Hideshima T,Chauhan D,Shima Y,Raje N,Davies FE,Tai YT,Treon SP,Lin B,Schlossman RL,Richardson P,Muller G,Stirling DI,Anderson KC

更新日期：2000-11-01 00:00:00

abstract：:Endotoxin is a component of gram-negative bacteria that causes hematologic and immunologic changes through its induction of cytokines. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of IL-1 that competes with IL-1 for occupancy of cell-surface receptors but possesses no agonist activity....

journal_title：Blood

authors： Granowitz EV,Porat R,Mier JW,Orencole SF,Callahan MV,Cannon JG,Lynch EA,Ye K,Poutsiaka DD,Vannier E

更新日期：1993-11-15 00:00:00

abstract：:Immunoglobulin E (IgE) bound to multivalent antigen (Ag) elicits mast cell degranulation but not survival; on the contrary, IgE in the absence of Ag (IgE(-Ag)) induces survival only but not degranulation. Although these distinct responses are mediated through the same receptor, FcepsilonRI, the molecular mechanism gen...

journal_title：Blood

authors： Yamasaki S,Ishikawa E,Kohno M,Saito T

更新日期：2004-04-15 00:00:00

abstract：:A cohort of MDS patients was examined for mutations affecting 4 splice genes (SF3B1, SRSF2, ZRSR2, and U2AF35) and evaluated in the context of clinical and molecular markers. Splice gene mutations were detected in 95 of 221 patients. These mutations were mutually exclusive and less likely to occur in patients with com...

journal_title：Blood

authors： Damm F,Kosmider O,Gelsi-Boyer V,Renneville A,Carbuccia N,Hidalgo-Curtis C,Della Valle V,Couronné L,Scourzic L,Chesnais V,Guerci-Bresler A,Slama B,Beyne-Rauzy O,Schmidt-Tanguy A,Stamatoullas-Bastard A,Dreyfus F,Prébet T,

更新日期：2012-04-05 00:00:00

abstract：:Ectopic expression of the erythropoietin receptor (EpoR) in the interleukin-3 (IL-3)-dependent cell line Ba/F3 results in growth and partial erythroid differentiation in Epo. In contrast, introduction and activation of the interleukin-5 receptor (IL-5R) or of the granulocyte-macrophage colony-stimulating factor recept...

journal_title：Blood

authors： Pless M,Norga K,Carroll M,Heim MH,D'Andrea AD,Mathey-Prevot B

更新日期：1997-05-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) is the most important cytokine involved in the promotion of myelofibrosis. Mechanisms leading to its local activation in the bone marrow environment remain unclear. As a recent study has highlighted the role of thrombospondin-1 (TSP-1) in platelet-derived TGF-β1 activation, we in...

journal_title：Blood

authors： Evrard S,Bluteau O,Tulliez M,Rameau P,Gonin P,Zetterberg E,Palmblad J,Bonnefoy A,Villeval JL,Vainchenker W,Giraudier S,Wagner-Ballon O

更新日期：2011-01-06 00:00:00

abstract：:The biochemical basis for complement acting directly on antigen-presenting cells to enhance their function in T-cell stimulation has been unclear. Here we present evidence that engagement of C3a receptor (C3aR) on the surface of dendritic cells (DCs) leads to alterations in the level of intracellular cyclic adenosine ...

journal_title：Blood

authors： Li K,Anderson KJ,Peng Q,Noble A,Lu B,Kelly AP,Wang N,Sacks SH,Zhou W

更新日期：2008-12-15 00:00:00

abstract：:Small nuclear U1-RNAs (snRNAs), the spliceosome components selectively recognizing donor splice sites (5'ss), were engineered to restore correct mRNA processing in a cellular model of severe coagulation factor VII (FVII) deficiency, caused by the IVS7 9726 + 5g/a change. Three U1-snRNAs, complementary to the mutated 5...

journal_title：Blood

authors： Pinotti M,Rizzotto L,Balestra D,Lewandowska MA,Cavallari N,Marchetti G,Bernardi F,Pagani F

更新日期：2008-03-01 00:00:00

abstract：:Mice homozygous for an autosomal recessive scid (severe combined immune deficiency) mutation on chromosome 16 exhibit a defect that specifically impairs lymphoid differentiation but not myelopoiesis. Consequently such mice are deficient in both humoral and cell-mediated immune functions. Despite their defect, scid mic...

journal_title：Blood

authors： Fulop GM,Phillips RA

更新日期：1989-10-01 00:00:00