Multiple gestations in assisted reproductive technology: can they be avoided with blastocyst transfers?

Abstract:

OBJECTIVE:Blastocysts are advanced-stage embryos with high implantation potential; theoretically, limited numbers of blastocysts can be used for embryo transfer to achieve good pregnancy rates with low multiple pregnancy rates. Clinical outcomes of a newly implemented blastocyst transfer program were evaluated. STUDY DESIGN:This study is a retrospective analysis of 553 blastocyst transfer cycles performed by a university-based in vitro fertilization program; risk factors associated with multiple gestations were analyzed. RESULTS:An average of 2.2 embryos were used for embryo transfer. The overall clinical pregnancy rate per embryo transfer was 45.1%; multiple gestation, twin, and triplet rates were 40.9%, 36.5%, and 4.3%, respectively. Multiple gestations increased significantly (1) when embryo transfer was done on day 5, (2) when > or =2 blastocysts were present on day 5, and (3) when maternal age was < or =30 years. CONCLUSION:In spite of a conservative approach to the number of blastocysts used for embryo transfer, the overall multiple pregnancy rate was high, and triplet pregnancies did occur.

journal_name

Am J Obstet Gynecol

authors

Gorrill MJ,Sadler-Fredd K,Patton PE,Burry KA

doi

10.1067/mob.2001.114851

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

1471-5; discussion 1475-7

issue

7

eissn

0002-9378

issn

1097-6868

pii

S0002937801893716

journal_volume

184

pub_type

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