Comprehensive drug screening by integrated use of gas chromatography/mass spectrometry and Remedi HS.

abstract：:Fifteen patients were studied during short-term (5 days at 10-15 mg/m2/day) or long-term (5-104 days at 3 mg/m2/day) doxorubicin infusion. Levels of doxorubicin and metabolites in serum and 24-h timed urine collections were determined by high-performance liquid chromatography. Quantifiable anthracycline levels were id...

journal_title：Therapeutic drug monitoring

authors： Sweatman TW,Lokich JJ,Israel M

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Nivolumab is a fully humanized IgG4 monoclonal antibody that targets the programmed death-1 (PD-1) receptor, disrupting PD-1-mediated signaling and restoring antitumor immunity. The objective of this study was to develop a nivolumab quantification method using liquid chromatography-tandem mass spectrometry (...

journal_title：Therapeutic drug monitoring

authors： Irie K,Okada A,Yamasaki Y,Kokan C,Hata A,Kaji R,Fukushima K,Sugioka N,Okada Y,Katakami N,Fukushima S

更新日期：2018-12-01 00:00:00

abstract：:The solubility and stability of amphotericin B in human serum in vitro was assessed using a sensitive high performance liquid chromatographic technique. The solubility of amphotericin B at concentrations ranging from 0.5 micrograms/ml to 10 micrograms/ml in human serum at pH 7.4, at 37 degrees C, and in 5% CO2 (simula...

journal_title：Therapeutic drug monitoring

authors： Edmonds LC,Davidson L,Bertino JS Jr

更新日期：1989-01-01 00:00:00

abstract：:A serious challenge in diagnosing fetal alcohol spectrum disorder (FASD) is the need to document alcohol use during pregnancy. Maternal/paternal alcohol abuse affects the likelihood of fetal alcohol exposure, and hence the occurrence of FASD. The objective of the current study was to document the use of the fatty acid...

journal_title：Therapeutic drug monitoring

authors： Kulaga V,Pragst F,Fulga N,Koren G

更新日期：2009-04-01 00:00:00

abstract：:The aim of this review is to provide information for interpreting outcome results from monitoring of antipsychotics in biological samples. A brief overview of the working mechanisms, pharmacological effects, drug interactions, and analytical methods of classical and atypical antipsychotics is given. Nineteen antipsych...

journal_title：Therapeutic drug monitoring

authors： Patteet L,Morrens M,Maudens KE,Niemegeers P,Sabbe B,Neels H

更新日期：2012-12-01 00:00:00

abstract：:5-Methoxy-N,N-dialkyltryptamines are tryptamine derivatives that possess strong hallucinogenic effects. Because of their escalating popularity and potent physiological effects, an increasing number of acute poisoning cases have been reported in various countries. For their metabolism in humans, only a few studies have...

journal_title：Therapeutic drug monitoring

authors： Katagi M,Kamata T,Zaitsu K,Shima N,Kamata H,Nakanishi K,Nishioka H,Miki A,Tsuchihashi H

更新日期：2010-06-01 00:00:00

abstract：:A high-performance liquid chromatography (HPLC) method was developed for the simultaneous analysis of trimethoprim (TMP), sulphamethoxazole (SMX), and acetylsulphamethoxazole (AcSMX) in small amounts of blood. The method involved precipitation with 50 microL trichloracetic acid (1M) to 125 microL plasma or serum sampl...

journal_title：Therapeutic drug monitoring

authors： Rønn AM,Mutabingwa TK,Kreisby S,Angelo HR,Fuursted K,Bygbjerg IC

更新日期：1999-12-01 00:00:00

abstract：:The postulated therapeutic activity of nortriptyline metabolites has prompted investigation of dosage adjustments based on plasma levels of nortriptyline (NT) and its metabolites. The method assumes that metabolite concentrations vary independently of nortriptyline concentrations among patients. This study tests that ...

journal_title：Therapeutic drug monitoring

authors： Lukey BJ,Jones DR,Wright JH,Hurst HE

更新日期：1989-01-01 00:00:00

abstract：:Eight commercial digoxin immunoassay methods were tested in 17 subjects taking spironolactone (but not digoxin) to evaluate cross-reactivity from parent drug and/or metabolites. Four of these methods showed significant (up to 1.9 nmol/L) and variable "apparent digoxin" concentrations, despite the absence of digoxin in...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Lagnado PY,Lehmann DR,Frewin DB,Glistak ML,Burnet RB

更新日期：1987-06-01 00:00:00

abstract：INTRODUCTION:Enoxaparin is an anticoagulant used in the treatment of thromboembolic diseases. It is a hydrophilic molecule that is, predominantly, eliminated renally with few data to support dosing for subjects with renal impairment and/or obesity. A recently conducted randomized controlled clinical trial compared indi...

journal_title：Therapeutic drug monitoring

authors： Barras MA,Duffull SB,Atherton JJ,Green B

更新日期：2010-08-01 00:00:00

abstract：:A gas chromatography-mass spectrometry (GC-MS)-based screening procedure was developed for the detection of diuretics, uricosurics, and/or their metabolites in human urine after extractive methylation. Phase-transfer catalyst remaining in the organic phase was removed by solid-phase extraction on a diol phase. The com...

journal_title：Therapeutic drug monitoring

authors： Beyer J,Bierl A,Peters FT,Maurer HH

更新日期：2005-08-01 00:00:00

abstract：:Plasma levels of 6-mercaptopurine were determined in 22 consecutive children with acute lymphoblastic leukemia on oral remission maintenance therapy during the time period of August 1984 to January 1988. Each child received the drug once daily for up to 3 years and was studied repeatedly (1-12 times). An HPLC method w...

journal_title：Therapeutic drug monitoring

authors： Hayder S,Lafolie P,Björk O,Peterson C

更新日期：1989-11-01 00:00:00

abstract：:The authors describe a rapid, useful, specific, and very sensitive high-performance liquid chromatographic assay for the determination of fluvastatin (FV) level using atorvastatin as the internal standard (IS). After a simple deproteinization of 1.0 mL of plasma with acetonitrile, the drug and IS were extracted with t...

journal_title：Therapeutic drug monitoring

authors： Al-Rawithi S,Hussein RF,Alzahrani A

更新日期：2003-02-01 00:00:00

abstract：:The enantioselectivity of hydroxylation of nortriptyline (NT) to E-10-hydroxynortriptyline (E-10-OH-NT) was studied in human liver microsomes, intestinal homogenate, and patients treated with NT. The rate of formation of (-)-E-10-OH-NT was higher than that of (+)-E-10-OH-NT both in the liver microsomes and in the inte...

journal_title：Therapeutic drug monitoring

authors： Dahl ML,Nordin C,Bertilsson L

更新日期：1991-05-01 00:00:00

abstract：:This study develops a population pharmacokinetic model for lamotrigine (LTG) in Spanish and German patients diagnosed with epilepsy. LTG steady-state plasma concentration data from therapeutic drug monitoring were collected retrospectively from 600 patients, with a total of 1699 plasma drug concentrations. The data we...

journal_title：Therapeutic drug monitoring

authors： Rivas N,Buelga DS,Elger CE,Santos-Borbujo J,Otero MJ,Domínguez-Gil A,García MJ

更新日期：2008-08-01 00:00:00

abstract：:The CYP2D6*10(*10) allele that causes decreased CYP2D6 activity is present in Asians with a high frequency of approximately 50%. We studied the effects of the *10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole. The subjects were 63 Japanese patients with...

journal_title：Therapeutic drug monitoring

authors： Suzuki T,Mihara K,Nakamura A,Nagai G,Kagawa S,Nemoto K,Ohta I,Arakaki H,Uno T,Kondo T

更新日期：2011-02-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) in combination with cyclosporine (CsA) or Tacrolimus (TAC) has been show to be a potent immunosuppressive agent. The authors assessed the mycophenolic acid (MPA) plasma levels achieved in clinical practice and evaluated the effect of concomitant administration of CsA and TAC . One hundred f...

journal_title：Therapeutic drug monitoring

authors： Pou L,Brunet M,Cantarell C,Vidal E,Oppenheimer F,Monforte V,Vilardell J,Roman A,Martorell J,Capdevila L

更新日期：2001-02-01 00:00:00

abstract：:We describe a patient with invasive pulmonary aspergillosis on extracorporeal membrane oxygenation therapy in which therapeutic drug monitoring and individualization of therapy by measuring voriconazole plasma concentrations were performed. ...

journal_title：Therapeutic drug monitoring

authors： Brüggemann RJ,Antonius T,Heijst Av,Hoogerbrugge PM,Burger DM,Warris A

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dosing based on systemic exposure. MITRA microsampling offers a convenient, minimally invasive approach for the collection of capillary blood samples from a fingerprick versus conventional venous blood...

journal_title：Therapeutic drug monitoring

authors： Undre N,Dawson I,Aluvihare V,Kamar N,Saliba F,Torpey N,Anaokar S,Kazeem G,Hussain I

更新日期：2020-12-03 00:00:00

abstract：:Recent literature has urged caution in the interpretation of vancomycin serum concentrations in patients with end-stage renal disease (ESRD), because falsely elevated levels in excess of 70% have been reported with the most commonly used fluorescence polarization immunoassay (FPIA). The purpose of this study was to ev...

journal_title：Therapeutic drug monitoring

authors： Smith PF,Petros WP,Soucie MP,Copeland KR

更新日期：1998-04-01 00:00:00

abstract：UNLABELLED:Oral fluid is an attractive alternative matrix for drug testing with a noninvasive and directly observed collection, but there are few controlled cocaine administration studies to guide interpretation. MATERIALS AND METHODS:While residing on a closed research unit for up to 10 weeks under constant medical s...

journal_title：Therapeutic drug monitoring

authors： Scheidweiler KB,Spargo EA,Kelly TL,Cone EJ,Barnes AJ,Huestis MA

更新日期：2010-10-01 00:00:00

abstract：:Digoxin and gentamicin are widely used in pediatric medicine, and therapeutic monitoring is mandatory because of their narrow margin of safety and wide interpatient and intrapatient pharmacokinetic variabilities. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is often diff...

journal_title：Therapeutic drug monitoring

authors： Berkovitch M,Bistritzer T,Aladjem M,Burtin P,Dagan T,Chen-Levi Z,Freedom R,Koren G

更新日期：1998-06-01 00:00:00

abstract：:A method for analyzing flecainide in plasma was developed and assessed. Based on the use of C18 extraction columns eight or fewer times, the rapid and simple extraction procedure provided consistent, high-efficiency flecainide extraction (>85%). Using reverse-phase, high-performance liquid chromatography with fluorome...

journal_title：Therapeutic drug monitoring

authors： Wilson KM,Schneider JJ,Ravenscroft PJ

更新日期：1998-08-01 00:00:00

abstract：:A 64-year-old man on chronic hemodialysis for end-stage renal disease developed peritoneal carcinomatosis, and palliative chemotherapy with fluorouracil was started. The drug was administered (325 mg/m as IV bolus, at 2 PM) on 2 separate occasions, ie, 1 hour after dialysis and 2 days later, 49 hours after dialysis. T...

journal_title：Therapeutic drug monitoring

authors： Gusella M,Rebeschini M,Cartei G,Ferrazzi E,Ferrari M,Padrini R

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Theophylline, a xanthine derivative drug, is used for the treatment of respiratory diseases, such as asthma, and is primarily eliminated by hepatic metabolism. There is marked interindividual variability in theophylline clearance. Therefore, the aim of this study was to evaluate the influence of chronic hepa...

journal_title：Therapeutic drug monitoring

authors： Kurata Y,Muraki S,Kashihara Y,Hirota T,Araki H,Ieiri I

更新日期：2020-12-01 00:00:00

abstract：:Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP) were studied in six depressed patients treated with trazodone. The daily dose of trazodone was 150 mg in three cases and 300 mg in three cases. Carbamazepine, 400 mg/day, was coad...

journal_title：Therapeutic drug monitoring

authors： Otani K,Ishida M,Kaneko S,Mihara K,Ohkubo T,Osanai T,Sugawara K

更新日期：1996-04-01 00:00:00

abstract：:The TDx digoxin II immunoassay was used in controls and in patients not taking digoxin or any other cardiac glycoside. We report the frequency of interference thought to be caused by digoxin-like factors (DLFs). We found a high incidence of false-positive results in 15 patients with severe hepatic disease (60% false-p...

journal_title：Therapeutic drug monitoring

authors： Avendaño C,Alvarez JS,Sacristan JA,Adin J,Alsar MJ

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Beta-lactams are first-line antibiotics for the management of superficial infections due to burn injury. There is sparse data available on therapeutic drug monitoring (TDM) in patients with burns in a ward setting. This study was conducted to evaluate the utility of a beta-lactam TDM program in a cohort of b...

journal_title：Therapeutic drug monitoring

authors： Patel BM,Paratz J,See NC,Muller MJ,Rudd M,Paterson D,Briscoe SE,Ungerer J,McWhinney BC,Lipman J,Roberts JA

更新日期：2012-04-01 00:00:00

abstract：:Our aim was to evaluate the isolated placental lobule to study maternofetal transplacental digoxin transfer and accumulation in placental tissue in vitro. Digoxin passage across the isolated lobule of 10 human placentas was calculated from repeated fetal and maternal perfusate samples, and placental tissue digoxin con...

journal_title：Therapeutic drug monitoring

authors： Schmolling J,Jung S,Reinsberg J,Schlebusch H

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Treatment with monoclonal antibodies (mAbs) against programmed cell death protein 1 receptor is subject to high variation in treatment outcome among cancer patients. For these agents, no exposure-response (ER) relationships have been investigated in routine health care settings. However, ER relationships hav...

journal_title：Therapeutic drug monitoring

authors： Basak EA,Wijkhuijs AJM,Mathijssen RHJ,Koolen SLW,Schreurs MWJ

更新日期：2018-10-01 00:00:00