Abstract：
INTRODUCTION:Pentoxifylline (PTX) is a phosphodiesterase inhibitor which has been found in studies in vitro to inhibit the production of Th-1 cytokines. It has been postulated that it might be used as a possible coadjuvant treatment for interferon in patients with multiple sclerosis. This would also reduce the potential side effects of interferon. OBJECTIVE. To show the efficacy of PTX in reducing the side effects of interferon, and in the functional improvement of these patients. PATIENTS AND METHODS:We studied 18 patients with remitting-relapsing multiple sclerosis over a period of 18 months; nine patients were given PTX and interferon 800 mg/day simultaneously, and nine patients were treated with interferon alone. The clinical condition was evaluated every three months using the Expanded Disability Status Scale (EDSS) and the Neurological Score (NRS) scales. RESULTS:We found no statistical improvement in the clinical course of EDSS and NRS in either group of patients after treatment for 18 months. The patients treated with PTX have fewer secondary effects due to interferon (fever and myalgia) during the first three months, but these differences between the groups subsequently disappear. In two patients PTX caused transient gastralgias and nauseas. CONCLUSIONS:PTX may be useful as a coadjuvant drug with interferon during the first three months of treatment since some of the side effects of interferon may thus be reduced. However, there seems no justification for using PTX for a longer period since there is no functional improvement.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Prieto JM,Dapena D,Lema M,Ares B,Cacabelos P,Noya Msubject
Has Abstractpub_date
2001-03-16 00:00:00pages
529-31issue
6eissn
0210-0010issn
1576-6578journal_volume
32pub_type
临床试验,杂志文章,随机对照试验abstract：INTRODUCTION AND CLINICAL CASE:A 58-year-old hypertensive man presented with the sudden onset of quadriplegia and inability to protrude the tongue. Magnetic resonance imaging showed a bilateral medial medullary infarction associated with an abnormally dilated and partially occluded vertebral artery. CONCLUSION:This is...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：INTRODUCTION:Addiction to drugs is a chronic illness with severe repercussions for those that consume them and to date has no known cure. Psychostimulants, such as ecstasy, are the most widely consumed illegal drugs among adolescents and young adults. AIMS:To describe and to analyse the different variables that can in...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2017-11-16 00:00:00
abstract：INTRODUCTION:The direct application of different types of cells to the central nervous system (CNS) by means of transplants, so-called cell therapy, is an experimental approach that promotes the characterisation of the cell and molecular mechanisms involved in the development, plasticity and regeneration of damage to t...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2009-11-01 00:00:00
abstract：INTRODUCTION:Cerebrotendinous xanthomatosis is an inherited autosomal recessive lipid storage disease. Clinical features include tendon xanthomas, premature cataracts and progressive neurologic dysfunctions. Substantial elevation of serum cholestanol and urinary bile alcohols and their precursors establishes the diagno...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：OBJECTIVE:To present a case with several cutaneous hemangiomas associated with intracranial hemangiomas and possibly with an intrahepatic hemangioma. CASE REPORT:A boy, 17 months old, showing several cutaneous hemangiomas and epileptic seizures resisting to antiepileptic medication, who also presented psychomotor reta...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：INTRODUCTION:Cavernous angiomas are angiographically occult vascular malformations that are present in 0.4% of people, and represent 5 13% of all cerebrovascular malformations. They can be alone or multiple, and sporadic or familial. The presence of multiple lesions is more frequent in familial cavernomatosis. OBJECTI...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:To review current literature on population, cytogenetic and molecular studies of specific language disorders (SLD) and pervasive developmental disorders (PDD). DEVELOPMENT:Clinical concordance studies in twins and in vertical familial groups suggest polygenic multifactorial modes of inheritance, but in some...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2002-07-01 00:00:00
abstract：INTRODUCTION:Olivopontocerebellar atrophy (OPCA) is a degenerative disease of the nervous system (NS) which currently has no known cure. The neuronal depopulation it brings about produces a number of neurochemical alterations, including a reduction in levels of gamma-aminobutyric acid (GABA) in tissues and in cerebrosp...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：:In recent years there has been a striking increase in the number of transnational adoptions in our country, which follows the trend already observed in other developed European countries. Major contributing factors to this phenomenon have been the improvements in socioeconomic conditions in our country, the drop in th...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-02-01 00:00:00
abstract：INTRODUCTION:It is a well-known fact that a relatively high proportion of patients with essential tremor are resistant to a number of pharmaceuticals currently used to treat the condition. AIM:To assess the effectiveness and safety of levetiracetam (LEV) in patients who displayed little or no response or intolerable s...
journal_title：Revista de neurologia
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-08-01 00:00:00
abstract：INTRODUCTION:Immigration is shaping a new model of society, with new needs and demands, whose characteristics must guide health-care policies. AIM. To determine the repercussions of the phenomenon of immigration on the extra-hospital neurological care carried out in Department 16 of the Agencia Valenciana de Salud (Val...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2009-08-16 00:00:00
abstract：:Disorders of gait are a common problem in elderly people. It is estimated that over 15% of people aged over 65 years have disorders of gait. Disorders of balance are also common in old age, with increased risk of falling and lesions due to falls. Every year 20-30% of the elderly people living alone have falls. The cau...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：:In the last years there is an increasing interest in the knowledge of vascular status in patients with acute stroke. Detection and localization of an artery occlusion is of great interest for an accurate prognosis and the selection of the most appropriate recanalizing therapy. Neurosonology is a useful diagnostic tool...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:To test the clinical nature and diversity of specific language impairment (SLI) in Spanish individuals, in the framework of the neuropsycholinguistic model of Chevrie-Muller and the classification of Rapin and Allen. PATIENTS AND METHODS:Forty two language impaired children with normal intelligence and audi...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2003-02-01 00:00:00
abstract：:By means of the modified trichromic method of Gomori, introduced by Engel and Cunningham in 1963 [1], it has been possible to demonstrate the presence of ragged-red fibers (RRF) in the mitochondrial myopathies. At present, to study these disorders in muscle biopsies, one may also use morphological, ultrastructural, hi...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-04-01 00:00:00
abstract：INTRODUCTION:Congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV (HSAN IV) is a rare autosomal recessive disorder featuring recurrent fever episodes, inability to sweat, absent response to noxious stimuli, self mutilating behavior and mental retardation. It has...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2005-08-16 00:00:00
abstract：INTRODUCTION:Parkinson's disease (PD) is characterized by motor symptoms such as bradykinesia, rigidity, alteration of postural reflexes and tremor at rest and other non-motor symptoms such as changes in sleep patterns and sexual behavior. However, little is known about paraphilic sexual behaviors. AIM:To summarize th...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2018-08-16 00:00:00
abstract：:The HMG-CoA reductase inhibitors (known as statins) have been shown to reduce morbi-mortality of vascular origin, including transitory ischemic accidents and cerebral infarcts, in a large group of patients. The implications, both clinical and of costs, oblige us to consider analysis of the existing evidence and the an...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：INTRODUCTION:Various neuropsychological studies have been conducted to determine the cognitive functioning of patients with Huntington s disease and their results have shown that the pattern of cognitive decline is thought to be typical of a frontal subcortical dementia. OBJECTIVES:To determine if significant differen...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：INTRODUCTION:We describe a patient diagnosed as suffering from a skull base osteochondroma which affected the atlantooccipital joint and originated in the occipital condyle. It also displayed a growth toward the foramen magnum, which was resected using an extreme lateral transcondylar approach. CASE REPORT:Patient age...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-01-16 00:00:00
abstract：INTRODUCTION:Primary prevention by prophylactic vaccination against the major cause of cervical cancer, the carcinogenic human papillomavirus (HPV) types 16 and 18, is now available worldwide. Postlicensure adverse neurological effects have been described. The studies realized after the license are descriptive and limi...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2011-04-16 00:00:00
abstract：:The established risk factors for ischemic stroke do not sufficiently explain all clinical and epidemiological features of the disease, such as the winter peak of stroke incidence, the decline of stroke during this century and the time point of cerebral ischemia. A role of infectious disease as stroke risk factor may p...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：INTRODUCTION:Epidemiological studies have demonstrated contradictory results about the association between smoking and the risk of Parkinson s disease (PD). OBJECTIVE:Examine the hypothesis of the EUROPARKINSON group that smoking protects against PD only in patients below 75 years of age. MATERIAL AND METHODS:We cond...
journal_title：Revista de neurologia
pub_type： 杂志文章,meta分析
doi：
更新日期：2003-03-16 00:00:00
abstract：:We report a 25-year-old woman with gradual loss of visual acuteness, during puerperium and blindness in fifteen days. Two months latter she remain steady. Visual evoked potentials using monocular checkerboard pattern-reversal, were abnormal. Clinical suspicion of voluntary alteration of VEP was considered. A second VE...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：SUMMARY INTRODUCTION:Several different indigenous groups (Yamana, Selk'nam, Alacaluf, Haush) used to inhabit the Patagonian region of Tierra de Fuego, but are now extinct. AIM:To analyse the healing practices that these prehistoric aborigines used to treat headaches and to compare them with those observed in other ant...
journal_title：Revista de neurologia
pub_type： 历史文章,杂志文章
doi：
更新日期：2008-10-01 00:00:00
abstract：INTRODUCTION:In recent years the demand for ambulatory neurological care has risen. Studying this situation can help to improve health care planning and the quality of the referrals from primary care. AIM:To analyse a number of variables involved in the first visits referred from primary care to neurology services. P...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:The cognitive effects of long-term exposure to organic solvents could be similar to those triggered by certain neurodegenerative diseases. AIMS:The purpose of this study was to evaluate the effects exerted by accumulated exposure on the cognitive functions. PATIENTS AND METHODS:105 subjects with an avera...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：AIM:To determine if women with multiple sclerosis (MS) reported an increased risk of breast cancer compared with the general female population. PATIENTS AND METHODS:We conducted a systematic review and meta-analysis of observational cohort studies. We performed a search in PubMed/Medline of studies where standardized ...
journal_title：Revista de neurologia
pub_type： 杂志文章,meta分析,评审
doi：
更新日期：2010-11-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:Preliminary studies (phase III) have shown that treatment with beta-interferon 1a (avonex) is effective in diverse aspects of relapsing/remitting multiple sclerosis (RRMS). The present study discusses results of an opened prolonged (phase IV) trial at the Baylor/Methodist International Multip...
journal_title：Revista de neurologia
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Chronic migraine (that is to say, cases where migraine is suffered on 15 or more days per month) is an illness that affects approximately 0.5-2.5% of the population, depending on the statistics that are analysed and the definition of chronic migraine used. The incidence of transformation from episodic to chronic migra...
journal_title：Revista de neurologia
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-10 00:00:00
