Male sex predominance in Chlamydia trachomatis sexually acquired reactive arthritis: are women more protected by anti-chlamydia antibodies?

abstract：INTRODUCTION:Endoplasmic reticulum aminopeptidase-1 (ERAP1) protein is highly polymorphic with numerous missense amino acid variants. We sought to determine the naturally occurring ERAP1 protein allotypes and their contribution to Behçet's disease. METHODS:Genotypes of all reported missense ERAP1 gene variants with 10...

journal_title：Annals of the rheumatic diseases

authors： Takeuchi M,Ombrello MJ,Kirino Y,Erer B,Tugal-Tutkun I,Seyahi E,Özyazgan Y,Watts NR,Gül A,Kastner DL,Remmers EF

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of age on the effectiveness and tolerance of antitumour necrosis factor alpha (TNFalpha) therapy in rheumatoid arthritis (RA). METHODS:730 patients of the Dutch Rheumatoid Arthritis Monitoring (DREAM) register were categorised into three groups according to their age at initiatio...

journal_title：Annals of the rheumatic diseases

authors： Radovits BJ,Kievit W,Fransen J,van de Laar MA,Jansen TL,van Riel PL,Laan RF

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:Improved DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) technology was used to monitor the changes in the galactosylation status of serum immunoglobulins during the immune response and therapy of autoimmune arthritis. METHODS:Collagen-induced arthritis (CIA) was induced in ...

journal_title：Annals of the rheumatic diseases

authors： Van Beneden K,Coppieters K,Laroy W,De Keyser F,Hoffman IE,Van den Bosch F,Vander Cruyssen B,Drennan M,Jacques P,Rottiers P,Verbruggen G,Contreras R,Callewaert N,Elewaut D

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Spondyloarthritis is a group of articular disorders sharing a genetic background. Polymorphisms in the IL-1 gene cluster have previously been associated with ankylosing spondylitis (AS), a subset of spondyloarthritis. This study examined the association between several of these polymorphisms and the whole spo...

journal_title：Annals of the rheumatic diseases

authors： Monnet D,Kadi A,Izac B,Lebrun N,Letourneur F,Zinovieva E,Said-Nahal R,Chiocchia G,Breban M

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To analyse fibronectin (FN) gene polymorphisms in type II mixed cryoglobulinemic syndrome (MCsn), an immune-complex mediated systemic vasculitis linked to hepatitis C virus (HCV) infection and characterised by rheumatoid factor (RF) positive B-cell proliferation at high risk for the progression into non-Hodgk...

journal_title：Annals of the rheumatic diseases

authors： Fabris M,Quartuccio L,Salvin S,Pozzato G,De Re V,Mazzaro C,Ferri C,Baldini C,De Vita S

更新日期：2008-01-01 00:00:00

abstract：:Eye disease, arthritis, folliculitis, and thrombophlebitis were more common among males, and erythema nodosum among females, in 297 patients with Behćet syndrome (BS) at their first visit despite an identical disease duration. Younger males and females (age of onset 24 years or less) had a higher prevalence of eye dis...

journal_title：Annals of the rheumatic diseases

authors： Yazici H,Tüzün Y,Pazarli H,Yurdakul S,Ozyazgan Y,Ozdoğan H,Serdaroğlu S,Ersanli M,Ulkü BY,Müftüoğlu AU

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVES:Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand pathogenic immune responses and manipulate them for therapeutic purposes. Unfortunately, direct investigat...

journal_title：Annals of the rheumatic diseases

authors： Spreafico R,Rossetti M,van Loosdregt J,Wallace CA,Massa M,Magni-Manzoni S,Gattorno M,Martini A,Lovell DJ,Albani S

更新日期：2016-02-01 00:00:00

abstract：:The relation of habitual knuckle cracking to osteoarthrosis with functional impairment of the hand has long been considered an old wives' tale without experimental support. The mechanical sequelae of knuckle cracking have been shown to produce the rapid release of energy in the form of sudden vibratory energy, much li...

journal_title：Annals of the rheumatic diseases

authors： Castellanos J,Axelrod D

更新日期：1990-05-01 00:00:00

abstract：:The effect of transforming growth factor beta (TGF beta) on proteoglycan synthesis and degradation in anatomically intact articular cartilage of murine patellae was studied. Exogenously added TGF beta up to a concentration of 200 pmol/l had no effect on proteoglycan synthesis in intact articular cartilage. Neutralisat...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,van den Berg WB

更新日期：1992-05-01 00:00:00

abstract：INTRODUCTION:The molecular mechanisms of syndesmophyte formation in ankylosing spondylitis (AS) are yet to be characterised. Molecules involved in bone formation such as Wnt proteins and their antagonists probably drive syndesmophyte formation in AS. METHODS:This study investigated sequential serum levels of functiona...

journal_title：Annals of the rheumatic diseases

authors： Heiland GR,Appel H,Poddubnyy D,Zwerina J,Hueber A,Haibel H,Baraliakos X,Listing J,Rudwaleit M,Schett G,Sieper J

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Treatment with tumour necrosis factor inhibitors (TNF-i) plus methotrexate (MTX), but not MTX monotherapy alone, inhibits joint damage progression even at higher levels of disease activity. Such disassociation of disease activity and structural damage has not been shown for biological agents other than TNF-i...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Avila JC,Aletaha D

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular cartilage structure predict knee replacement, and to establish their utility as outcomes in cli...

journal_title：Annals of the rheumatic diseases

authors： Eckstein F,Kwoh CK,Boudreau RM,Wang Z,Hannon MJ,Cotofana S,Hudelmaier MI,Wirth W,Guermazi A,Nevitt MC,John MR,Hunter DJ,OAI investigators.

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:The severity of joint destruction is highly variable between rheumatoid arthritis (RA) patients. The majority of its heritability is still unexplained. Several autoimmune diseases share genetic risk variants that may also influence disease progression. We aimed to identify genetic risk factors for the severi...

journal_title：Annals of the rheumatic diseases

authors： de Rooy DP,Zhernakova A,Tsonaka R,Willemze A,Kurreeman BA,Trynka G,van Toorn L,Toes RE,Huizinga TW,Houwing-Duistermaat JJ,Gregersen PK,van der Helm-van Mil AH

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Molecular biological approaches have recently identified urate transporters in renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular ...

journal_title：Annals of the rheumatic diseases

authors： Urano W,Taniguchi A,Anzai N,Inoue E,Kanai Y,Yamanaka M,Endou H,Kamatani N,Yamanaka H

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Patients with rheumatoid arthritis (RA) are at increased risk of myocardial infarction (MI) compared with subjects without RA, with the increased risk driven potentially by inflammation. Tumour necrosis factor inhibitors (TNFi) may modulate the risk and severity of MI. We compared the risk and severity of MI...

journal_title：Annals of the rheumatic diseases

authors： Low AS,Symmons DP,Lunt M,Mercer LK,Gale CP,Watson KD,Dixon WG,Hyrich KL,British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA) and the BSRBR Control Centre Consortium.

更新日期：2017-04-01 00:00:00

abstract：:Structural damage assessed on conventional radiographs is an important outcome measure in psoriatic arthritis. This article reviews the available scoring methods. A full description of the methods is given as well as information on various aspects of validity. ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde D,Sharp J,Wassenberg S,Gladman DD

更新日期：2005-03-01 00:00:00

abstract：:There is a close relation between T helper (Th) 1 cells and nitric oxide in disease. Thus it is possible that a reciprocal regulatory mechanism exists between them. This paper briefly describes the experimental studies which have helped elucidate the mechanism by which nitric oxide selectively enhances Th 1 cell proli...

journal_title：Annals of the rheumatic diseases

authors： Niedbala W,Cai B,Liew FY

更新日期：2006-11-01 00:00:00

abstract：:This paper looks at the problem confronting a doctor evaluating a patient with anticentromere antibody who does not have evidence of disease along the spectrum from CREST (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) to progressive systemic sclerosis. Of 33 people with anti...

journal_title：Annals of the rheumatic diseases

authors： Goldman JA

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:A number of tumour necrosis factor α (TNFα) antagonists (anti-TNFα) are available to treat rheumatoid arthritis. All of these have demonstrated considerable efficacy in placebo controlled trials, but few head-to-head comparisons exist to date. This work's objective is to estimate the relative efficacy among ...

journal_title：Annals of the rheumatic diseases

authors： Schmitz S,Adams R,Walsh CD,Barry M,FitzGerald O

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with rheumatoid arthritis (RA). METHODS:Immunohistochemistry was performed in synovial biopsies from patients with RA (n=20), osteoarthritis (...

journal_title：Annals of the rheumatic diseases

authors： Chemel M,Le Goff B,Brion R,Cozic C,Berreur M,Amiaud J,Bougras G,Touchais S,Blanchard F,Heymann MF,Berthelot JM,Verrecchia F,Heymann D

更新日期：2012-01-01 00:00:00

abstract：:Orally bioavailable compounds that target key intracellular signalling molecules are receiving increasing attention for the treatment of rheumatic diseases. The mitogen activated protein (MAP) kinases are especially attractive because they regulate both cytokine production and cytokine action. The MAP kinases are expr...

journal_title：Annals of the rheumatic diseases

authors： Sweeney SE,Firestein GS

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is characterised by the presence of antibodies to double stranded DNA (dsDNA), which are involved in the pathogenesis of SLE. Previous studies showed that at least two thirds of patients develop a clinical relapse within six months after a significant rise in the anti-dsDNA...

journal_title：Annals of the rheumatic diseases

authors： Bijl M,Horst G,Bootsma H,Limburg PC,Kallenberg CG

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:To study the effect of meloxicam (MXC) and diclofenac (DCF) on the recruitment of leucocytes during acute experimental arthritis. METHODS:Rabbits with antigen-induced arthritis were treated with MXC, DCF, or not treated. After 48 hours, synovial fluid (SF) leucocyte influx and prostaglandin E(2) (PGE(2)) lev...

journal_title：Annals of the rheumatic diseases

authors： López-Armada MJ,Sánchez-Pernaute O,Largo R,Diez-Ortego I,Palacios I,Egido J,Herrero-Beaumont G

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:Expression of major histocompatibility complex (MHC) class II genes is almost exclusively regulated by the class II transactivator. A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarctio...

journal_title：Annals of the rheumatic diseases

authors： Martínez A,Sánchez-Lopez M,Varadé J,Mas A,Martín MC,de Las Heras V,Arroyo R,Mendoza JL,Díaz-Rubio M,Fernández-Gutiérrez B,de la Concha EG,Urcelay E

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the influences of radiographic severity, quadriceps strength, knee pain, age, and gender on functional ability in patients with osteoarthritis of the knee. METHODS:Equal numbers of knee pain positive and negative respondents to a survey of registrants aged more than 55 years at a general practic...

journal_title：Annals of the rheumatic diseases

authors： McAlindon TE,Cooper C,Kirwan JR,Dieppe PA

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive value of discordance between (1) tender and swollen joint count and (2) patient's and evaluator's global assessment on remission in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS:From the prospective, multicentre Norwegian-Disease-Modifying Antirh...

journal_title：Annals of the rheumatic diseases

authors： Michelsen B,Kristianslund EK,Hammer HB,Fagerli KM,Lie E,Wierød A,Kalstad S,Rødevand E,Krøll F,Haugeberg G,Kvien TK

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a serious multisystem autoimmune disease, mediated by disrupted B cell quiescence and typically treated with glucocorticoids. We studied whether B cells in SLE are regulated by the glucocorticoid-induced leucine zipper (GILZ) protein, an endogenous mediator of anti-infla...

journal_title：Annals of the rheumatic diseases

authors： Jones SA,Toh AE,Odobasic D,Oudin MA,Cheng Q,Lee JP,White SJ,Russ BE,Infantino S,Light A,Tarlinton DM,Harris J,Morand EF

更新日期：2016-04-01 00:00:00

abstract：:A 62 year old woman taking L-tryptophan developed eosinophilic fasciitis shortly after starting an exercise class. She received prednisone without benefit but improved after azathioprine treatment was started and L-tryptophan was discontinued. As products containing L-tryptophan have recently been implicated in develo...

journal_title：Annals of the rheumatic diseases

authors： Hamilton ME

更新日期：1991-01-01 00:00:00

abstract：:In the use of anti-inflammatory compounds, sustained serum levels are thought to be related to drug efficacy. This study shows that frequent clinical administration of indomethacin can result in sustained serum levels of the drug and that food and antacid may have important modifying effects on serum indomethacin conc...

journal_title：Annals of the rheumatic diseases

authors： Emori HW,Paulus H,Bluestone R,Champion GD,Pearson C

更新日期：1976-08-01 00:00:00

abstract：OBJECTIVE:To determine discrepancies in patients' current use and expected future use of the internet for different functions. METHOD:A short questionnaire was developed to assess patients' current use of the internet for three functions: "seeking information", "mutual support", and "care provider contact". This quest...

journal_title：Annals of the rheumatic diseases

authors： van Lankveld WG,Derks AM,van den Hoogen FH

更新日期：2006-01-01 00:00:00