Genetic variation of the methylenetetrahydrofolate reductase and cystathionine beta-synthase genes in Korean patients with coronary artery disease and a new polymorphism in intron 7.

Abstract:

:We investigated polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes in Korean patients with coronary artery disease (CAD) and identified a new polymorphism (c-->t) in intron 7 of the CBS gene using the single-strand conformation polymorphism method. No significant differences were found in allele frequencies for either gene between the CAD and normal groups although the frequency of the so-called thermolabile MTHFR polymorphism, a proposed risk factor for CAD, was higher in Koreans than in other populations studied. The relatively low incidence of CAD in Korea suggests that this MTHFR polymorphism is not causative in this population.

journal_name

Mol Cell Probes

authors

Hong SH,Song J,Kim JQ

doi

10.1006/mcpr.2001.0351

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

119-23

issue

2

eissn

0890-8508

issn

1096-1194

pii

S0890-8508(01)90351-2

journal_volume

15

pub_type

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