Limited usefulness of a seven-day twice-a-day quadruple therapy.

Abstract:

OBJECTIVE:To test the usefulness of a twice-a-day, simplified quadruple therapy to cure Helicobacter pylori infection. DESIGN:Helicobacter pylori-positive ulcer patients were treated with omeprazole 20 mg twice a day (b.d.), amoxicillin 1 g b.d., tinidazole 500 mg b.d. and bismuth subcitrate 240 mg b.d. for 7 days in an experimental, noncomparative pilot study. SETTING:The gastroenterology unit of a county hospital. PARTICIPANTS:Forty-four consecutive patients with peptic ulcer disease and H. pylori infection. MEASUREMENTS:Cure was tested by either endoscopy or breath test after 2 months, and by urea breath test 6 months after therapy. RESULTS:One patient was lost to follow-up. Of the remaining 43, 37 were cured at the first control, giving an intention-to-treat cure rate of 84.1% (95% CI 69-93%) and a per protocol cure rate of 86% (95% CI 71-94%). Thirty-three cured patients agreed to return for a six-month breath test. All but one were cured (long-term per protocol cure rate 82.1%; 95% CI 66-92%). CONCLUSIONS:This particular quadruple therapy is well tolerated and easy to comply with. However, cure rates did not reach 90%.

authors

Garcia N,Calvet X,Gené E,Campo R,Brullet E

doi

10.1097/00042737-200012120-00008

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1315-8

issue

12

eissn

0954-691X

issn

1473-5687

journal_volume

12

pub_type

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