Platelet-derived growth factor causes endothelium-independent relaxation of rabbit mesenteric artery via the release of a prostanoid.

abstract：:We have characterized the contribution of endothelial nitric oxide synthase (eNOS), cyclo-oxygenase (COX) and cytochrome P450 (CYP450) to the bradykinin (BK)- induced vasodilation in isolated hearts from wildtype (WT) and eNOS deficient mice (eNOS-/-). The endothelium-dependent vasodilation by bradykinin (BK, 1 microM...

journal_title：British journal of pharmacology

authors： Ding Z,Gödecke A,Schrader J

更新日期：2002-02-01 00:00:00

abstract：:1 Tegaserod (Zelnorm) is a potent 5-hydroxytryptamine4 (5-HT4) receptor agonist with clinical efficacy in disorders associated with reduced gastrointestinal motility and transit. The present study investigated the interaction of tegaserod with 5-HT2 receptors, and compared its potency in this respect to its 5-HT4 rece...

journal_title：British journal of pharmacology

authors： Beattie DT,Smith JA,Marquess D,Vickery RG,Armstrong SR,Pulido-Rios T,McCullough JL,Sandlund C,Richardson C,Mai N,Humphrey PP

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effects of systemic treatment with indomethacin-loaded nanocapsules (IndOH-NC) were compared with those of free indomethacin (IndOH) in rat models of acute and chronic oedema. EXPERIMENTAL APPROACH:The following models of inflammation were employed: carrageenan-induced acute oedema (measured...

journal_title：British journal of pharmacology

authors： Bernardi A,Zilberstein AC,Jäger E,Campos MM,Morrone FB,Calixto JB,Pohlmann AR,Guterres SS,Battastini AM

更新日期：2009-10-01 00:00:00

abstract：:Cyclo-oxygenase (COX) inhibitors potentiate opioid inhibition of GABAergic synaptic transmission in rat periaqueductal grey (PAG) (Vaughan et al., 1997). In the present study, the relative contribution of cyclo-oxygenase-1 (COX-1) and COX-2 inhibition to this phenomenon was examined by use of whole-cell patch clamp re...

journal_title：British journal of pharmacology

authors： Vaughan CW

更新日期：1998-04-01 00:00:00

abstract：:1. The action of the non-steroidal anti-inflammatory drugs (NSAID), sodium salicylate, aspirin, phenylbutazone and indomethacin was investigated on the migration of human polymorphonuclear cells (PMNs) and lymphocytes, using the system of migration of leucocytes from glass capillary tubes. 2. All NSAID produced a dose...

journal_title：British journal of pharmacology

authors： Brown KA,Collins AJ

更新日期：1978-11-01 00:00:00

abstract：:Expression of two isoforms of Rho-kinase (ROCK) and its functional role in the physiological control of smooth muscle contraction in the sheep ureter were investigated. Helical strips of the ureteric smooth muscle were stimulated by electrical field stimulation (EFS, 60 V, 1 mS, 2, 4, 8, 16 and 32 Hz, for 20 S), KCl (...

journal_title：British journal of pharmacology

authors： Levent A,Büyükafsar K

更新日期：2004-10-01 00:00:00

abstract：:1. We have investigated the potency and duration of action of isoprenaline and a range of beta-adrenoceptor agonists as relaxants of inherent tone in human superfused, isolated bronchial smooth muscle, a tissue reported to contain a homogeneous population of beta 2-adrenoceptors. 2. All of the beta-adrenoceptor agonis...

journal_title：British journal of pharmacology

authors： Nials AT,Coleman RA,Johnson M,Magnussen H,Rabe KF,Vardey CJ

更新日期：1993-11-01 00:00:00

abstract：:1. Reserpine given to rats before the enhanced synthesis of DNA begins 14h after partial hepatectomy markedly depresses thymidine uptake into DNA at 24 hours.2. At this time decreased activity of liver thymidine kinase but unchanged thymidine 5'-nucleotidase were observed.3. Reserpine has no effect on DNA synthesis wh...

journal_title：British journal of pharmacology

authors： Cihák A,Vaptzarova K

更新日期：1973-10-01 00:00:00

abstract：:1. 5-Hydroxytryptamine (5-HT) is known to produce a number of different effects in the gastrointestinal tract of various species, and has been proposed to play a key role in a number of intestinal disorders in man, including irritable bowel syndrome (IBS), although the receptors involved have yet to be established. Th...

journal_title：British journal of pharmacology

authors： Borman RA,Tilford NS,Harmer DW,Day N,Ellis ES,Sheldrick RL,Carey J,Coleman RA,Baxter GS

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Muscarinic toxins (MTs) are snake venom peptides named for their ability to interfere with ligand binding to muscarinic acetylcholine receptors (mAChRs). Recent data infer that these toxins may have other G-protein-coupled receptor targets than the mAChRs. The purpose of this study was to systema...

journal_title：British journal of pharmacology

authors： Näreoja K,Kukkonen JP,Rondinelli S,Toivola DM,Meriluoto J,Näsman J

更新日期：2011-09-01 00:00:00

abstract：:1. Poly(2-vinylpyridine 1-oxide) counteracts the pathogenic effects normally produced when quartz is injected into or inhaled by animals and the cytotoxic effects when quartz is added to macrophage cultures. The protective action of this polymer has been attributed variously to the formation of an adsorbed layer on th...

journal_title：British journal of pharmacology

authors： Holt PF,Lindsay H,Beck EG

更新日期：1970-01-01 00:00:00

abstract：:1 The venom of the green mamba, Dendroaspis angusticeps, was tested for effects on neuromuscular transmission and skeletal muscle contractility in isolated phrenic nerve-hemidiaphragm preparations of the rat and mouse, chick biventer cervicis muscle preparations and in aneural cultures of embryonic chick skeletal musc...

journal_title：British journal of pharmacology

authors： Barrett JC,Harvey AL

更新日期：1979-10-01 00:00:00

abstract：:The effects of verapamil on the contraction of the guinea-pig tracheal smooth muscle induced by calcium (Ca2+) or barium (Ba2+) were investigated in three different conditions: (a) in excess K solution, (b) in the presence of carbachol, and (c) in excess K solution containing carbachol. In order to clarify the contrac...

journal_title：British journal of pharmacology

authors： Baba K,Satake T,Takagi K,Tomita T

更新日期：1986-06-01 00:00:00

abstract：:Until recently, hydrogen sulfide (H2 S) was exclusively viewed a toxic gas and an environmental hazard, with its toxicity primarily attributed to the inhibition of mitochondrial Complex IV, resulting in a shutdown of mitochondrial electron transport and cellular ATP generation. Work over the last decade established mu...

journal_title：British journal of pharmacology

authors： Szabo C,Ransy C,Módis K,Andriamihaja M,Murghes B,Coletta C,Olah G,Yanagi K,Bouillaud F

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Histone deacetylase 6 (HDAC6) and silent information regulator 2 (SIRT2) control the dynamics of the microtubule network via their deacetylase activities. Tubulin polymerization promoting protein (TPPP/p25) enhances microtubule acetylation by its direct binding to HDAC6. Our objective was to char...

journal_title：British journal of pharmacology

authors： Mangas-Sanjuan V,Oláh J,Gonzalez-Alvarez I,Lehotzky A,Tőkési N,Bermejo M,Ovádi J

更新日期：2015-02-01 00:00:00

abstract：:1. A murine macrophage cell line, J774, expressed nitric oxide (NO) synthase activity in response to interferon-gamma (IFN-gamma, 10 u ml-1) plus lipopolysaccharide (LPS, 10 ng ml-1). The enzyme activity was first detectable 6 h after incubation, peaked at 12 h and became undetectable after 48 h. 2. The decline in the...

journal_title：British journal of pharmacology

authors： Assreuy J,Cunha FQ,Liew FY,Moncada S

更新日期：1993-03-01 00:00:00

abstract：:Tyrosine sulfation is a post-translational modification of secreted and transmembrane proteins, including many GPCRs such as chemokine receptors. Most chemokine receptors contain several potentially sulfated tyrosine residues in their extracellular N-terminal regions, the initial binding site for chemokine ligands. Su...

journal_title：British journal of pharmacology

authors： Ludeman JP,Stone MJ

更新日期：2014-03-01 00:00:00

abstract：:Association between staphylococcal infection and pathogenesis of upper airways disease has been reported. This study aimed to investigate the mechanisms underlying the rat pulmonary inflammation induced by airway exposure to staphylococcal enterotoxin A (SEA). SEA (0.3-10 ng trachea(-1)) caused dose-dependent neutroph...

journal_title：British journal of pharmacology

authors： Desouza IA,Franco-Penteado CF,Camargo EA,Lima CS,Teixeira SA,Muscará MN,De Nucci G,Antunes E

更新日期：2005-11-01 00:00:00

abstract：:1. The noradrenaline (NA) concentration in the "heart" (atria and right ventricle) of male rats was estimated at different periods following adrenal demedullation. For 1-3 weeks after the operation there was, in all rats, a reduction in NA content of the tissue, whereas, after somewhat longer intervals, the concentrat...

journal_title：British journal of pharmacology

authors： Borchard F,Vogt M

更新日期：1970-01-01 00:00:00

abstract：:1. The potencies of some beta-adrenoreceptor blocking drugs in reducing noradrenaline uptake by the isolated heart were compared with their potencies in reducing the release of noradrenaline from the heart by tyramine.2. Of the drugs tested, propranolol, pronethalol and dichloroisoprenaline were the most potent in blo...

journal_title：British journal of pharmacology

authors： Foo JW,Jowett A,Stafford A

更新日期：1968-09-01 00:00:00

abstract：:1. A new series of cardiotonics based on five steroid nuclei has been evaluated for inhibition of Na-+/K-+-ATPase and Rb uptake by red blood cells, and for inotropic activity and toxicity in dogs. Structure-activity relationships are discussed. 2. The in vitro tests can be used satisfactorily to predict inotropic acti...

journal_title：British journal of pharmacology

authors： Beard NA,Rouse W,Somerville AR

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Emerging evidence indicates that hypertension is mediated by immune mechanisms. We hypothesized that exposure to Porphyromonas gingivalis antigens, commonly encountered in periodontal disease, can enhance immune activation in hypertension and exacerbate the elevation in BP, vascular inflammation ...

journal_title：British journal of pharmacology

authors： Czesnikiewicz-Guzik M,Nosalski R,Mikolajczyk TP,Vidler F,Dohnal T,Dembowska E,Graham D,Harrison DG,Guzik TJ

更新日期：2019-06-01 00:00:00

abstract：:1. 5-Hydroxytryptamine (5-HT) transport has been investigated in rat blood platelets poisoned with dinitrophenol-sodium fluoride or ouabain.2. The inhibition of transport produced by different concentrations of the metabolic inhibitors has been correlated with changes in the internal Na(+) and K(+) concentrations of t...

journal_title：British journal of pharmacology

authors： Sneddon JM

更新日期：1971-12-01 00:00:00

abstract：:Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are canonically activated by oxidized derivatives of cholesterol. Since the mid-90s, numerous groups have identified LXRs as endocrine receptors that are involved in the regulation of various physiological functions. As a result, when their ...

journal_title：British journal of pharmacology

authors： Buñay J,Fouache A,Trousson A,de Joussineau C,Bouchareb E,Zhu Z,Kocer A,Morel L,Baron S,Lobaccaro JA

更新日期：2020-10-20 00:00:00

abstract：:1. The effect of frusemide, ethacrynic acid and indanyloxyacetic acid was investigated on spontaneous calcium-activated chloride (ICl(Ca)) and potassium currents (IK(Ca)) in rabbit portal vein cells with the perforated patch technique. 2. Frusemide (0.3-1.0 x 10(-3) M) reduced the amplitude of spontaneous transient in...

journal_title：British journal of pharmacology

authors： Greenwood IA,Hogg RC,Large WA

更新日期：1995-07-01 00:00:00

abstract：:1. Intra-arterial blood pressures and heart rates were recorded in conscious, unrestrained, Long Evans and Brattleboro rats receiving sequential, continuous administrations of selective alpha 1- (prazosin) and alpha 2- (idazoxan) adrenoceptor antagonists. The same protocols were also run in the presence of ICI 118551 ...

journal_title：British journal of pharmacology

authors： Gardiner SM,Bennett T

更新日期：1988-01-01 00:00:00

abstract：:1 The effects of isoprenaline, propranolol and phosphodiesterase inhibitors on (3)H-transmitter overflow elicited by low frequency nerve stimulation were determined in the isolated perfused spleen of the cat.2 (-)-Isoprenaline (0.14, 1.4, and 14 nM) produced a concentration-dependent increase in [(3)H]-transmitter ove...

journal_title：British journal of pharmacology

authors： Celuch SM,Dubocovich ML,Lander SZ

更新日期：1978-05-01 00:00:00

abstract：:Using an in vitro mouse cerebellar slice preparation and whole-cell electrophysiological recording techniques we have characterized Purkinje and basket cell inhibitory post-synaptic currents (IPSCs), and examined the effects of a number of selective peptidergic K+ channel blockers. Spontaneous IPSC amplitude ranged fr...

journal_title：British journal of pharmacology

authors： Southan AP,Robertson B

更新日期：1998-11-01 00:00:00

abstract：:1. The effect on systemic haemodynamics of BQ-123, a selective endothelin A (ETA) receptor antagonist, was investigated in healthy men by giving, on separate occasions, ascending intravenous doses of 100, 300, 1000 and 3000 nmol min(-1) BQ-123, each for 15 min, in a randomized, placebo-controlled, double-blind study. ...

journal_title：British journal of pharmacology

authors： Spratt JC,Goddard J,Patel N,Strachan FE,Rankin AJ,Webb DJ

更新日期：2001-10-01 00:00:00

abstract：:1. The goal of this study was to investigate the effects of the delayed pharmacological preconditioning produced by an adenosine A(1)-receptor agonist (A(1)-DPC) against ventricular arrhythmias induced by ischaemia and reperfusion, compared to those of ischaemia-induced delayed preconditioning (I-DPC). 2. Eighty-nine ...

journal_title：British journal of pharmacology

authors： Tissier R,Souktani R,Parent de Curzon O,Lellouche N,Henry P,Giudicelli JF,Berdeaux A,Ghaleh B

更新日期：2001-12-01 00:00:00