In vitro effects of non-steroidal anti-inflammatory drugs on human polymorphonuclear cells and lymphocyte migration.

abstract：:1 The L6 myocyte cell line expresses high affinity receptors for calcitonin gene-related peptide (CGRP) which are coupled to activation of adenylyl cyclase. The biochemical pharmacology of these receptors has been examined by radioligand binding or adenosine 3':5'-cyclic monophosphate (cyclic AMP) accumulation. 2 In i...

journal_title：British journal of pharmacology

authors： Poyner DR,Andrew DP,Brown D,Bose C,Hanley MR

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Non-invasive in vivo imaging of cannabinoid CB2 receptors using PET is pursued to study neuroinflammation. The purpose of this study is to evaluate the in vivo binding specificity of [18 F]MA3, a CB2 receptor agonist, in a rat model with local overexpression of human (h) CB2 receptors. METHODS:[...

journal_title：British journal of pharmacology

authors： Attili B,Celen S,Ahamed M,Koole M,Haute CVD,Vanduffel W,Bormans G

更新日期：2019-05-01 00:00:00

abstract：:1. We studied the lactotroph cells of the rat by both in vivo and in vitro pharmacological techniques for the presence of D1-receptors. Both approaches revealed the presence of D2-receptor, stimulated by quinpirole (resulting in an inhibition of prolactin secretion) and blocked by domperidone. 2. Administration of fen...

journal_title：British journal of pharmacology

authors： Schoors DF,Vauquelin GP,De Vos H,Smets G,Velkeniers B,Vanhaelst L,Dupont AG

更新日期：1991-08-01 00:00:00

abstract：:1. The bovine pulmonary vein contracts in response to acetylcholine, histamine, 5-hydroxytryptamine and bradykinin. The tissue is particularly sensitive to 5-hydroxytryptamine (>0.1 ng/ml). Specific Schultz-Dale reactions were elicited in the pulmonary vein in response to horse plasma.2. The Schultz-Dale reaction is i...

journal_title：British journal of pharmacology

authors： Eyre P

更新日期：1971-10-01 00:00:00

abstract：:1 The effect of 5-hydroxytryptamine (5-HT) on acid secretion by a rat isolated stomach preparation has been studied. 2 5-HT at 10(-5)M in the serosal bathing fluid produced significant inhibition of the acid secretory responses to histamine, pentagastrin and isoprenaline but was without effect on basal secretion or th...

journal_title：British journal of pharmacology

authors： Canfield SP,Spencer JE

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:7-Ketocholesterol, an oxysterol present in atherosclerotic lesions, induces smooth muscle cell (SMC) death, thereby destabilizing plaques. Statins protect patients from myocardial infarction, though they induce SMC apoptosis. We investigated whether statins and 7-ketocholesterol exerted additive ...

journal_title：British journal of pharmacology

authors： Martinet W,Schrijvers DM,Timmermans JP,Bult H

更新日期：2008-07-01 00:00:00

abstract：:1. Effects of phorbol esters on the cytosolic Ca2+ level ([Ca2+]i) and muscle tension in the intestinal smooth muscle of guinea-pig taenia caeci were examined. 2. 12-Deoxyphorbol 13-isobutyrate (DPB, 1 microM) did not change the [Ca2+]i and tension in resting muscle. 3. In high K(+)-stimulated muscle, 1 microM DPB tra...

journal_title：British journal of pharmacology

authors： Mitsui M,Karaki H

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Here, we have compared the neurochemical profile of three new cathinones, butylone, mephedrone and methylone, in terms of their potential to inhibit plasmalemmal and vesicular monoamine transporters. Their interaction with 5-HT and dopamine receptors and their psychostimulant effect was also stud...

journal_title：British journal of pharmacology

authors： López-Arnau R,Martínez-Clemente J,Pubill D,Escubedo E,Camarasa J

更新日期：2012-09-01 00:00:00

abstract：:1. Caffeine has been widely used as a pharmacological tool to evaluate Ca(2+) release from the sarcoplasmic reticulum in isolated smooth muscle cells. However, in nervous tissue this drug also causes neurotransmitters release, which might cause additional effects when smooth muscle strips are evaluated. To assess this...

journal_title：British journal of pharmacology

authors： Montaño LM,Carbajal V,Arreola JL,Barajas-López C,Flores-Soto E,Vargas MH

更新日期：2003-07-01 00:00:00

abstract：:We examined the mechanisms underlying leukotriene D4- (LTD4) induced constriction of human small (300 - 500 micron i.d.) bronchioles, and the effect of LTD4 on ion currents and Ca2+ transients in smooth muscle cells (SMC) isolated from these bronchioles. LTD4 caused a concentration-dependent bronchoconstriction with a...

journal_title：British journal of pharmacology

authors： Snetkov VA,Hapgood KJ,McVicker CG,Lee TH,Ward JP

更新日期：2001-05-01 00:00:00

abstract：:1. In Ca-free solution, the contractile response of guinea-pig taenia caecum to 10(-4) M carbachol was mediated through muscarinic receptors and was reduced time-dependently by desensitization with 10(-4) M carbachol, but not 10(-4) M histamine. On the other hand, the response to 10(-4) M histamine was shown to be med...

journal_title：British journal of pharmacology

authors： Hishinuma S,Uchida MK

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cytochrome P450 (CYP, P450) 3A4 is involved in the metabolism of 50% of drugs and its catalytic activity in vivo is not explained only by hepatic expression levels. We previously demonstrated that UDP-glucuronosyltransferase (UGT) 2B7 suppressed CYP3A4 activity through an interaction. In the pres...

journal_title：British journal of pharmacology

authors： Miyauchi Y,Tanaka Y,Nagata K,Yamazoe Y,Mackenzie PI,Yamada H,Ishii Y

更新日期：2020-03-01 00:00:00

abstract：:1 U46619, a prostaglandin H2 endoperoxide analogue and thromboxane A2 agonist, dose-dependently inhibited accumulation and metabolism of thromboxane B2 in the isolated perfused lung of the guinea-pig. At similar doses prostaglandins E1, E2, F1 alpha, F2 alpha, I2, 5, 6-trans-PGE2 and 8-iso-PGE1 were ineffective. 2 U46...

journal_title：British journal of pharmacology

authors： Hoult JR,Robinson C

更新日期：1983-01-01 00:00:00

abstract：:1. The effect of central injection of selective kinin B1 and B2 receptor antagonists on the febrile response induced by endotoxin (E. coli lipopolysaccharide, LPS) in rats was investigated. 2. Intracerebroventricular (i.c.v.) injection of a selective B2 receptor antagonist (Hoe-140, 8 nmol) reduced the early (0-2 h), ...

journal_title：British journal of pharmacology

authors： Coelho MM,Oliveira CR,Pajolla GP,Calixto JB,Pelá IR

更新日期：1997-05-01 00:00:00

abstract：:1. We measured the effects of agonists and antagonists of metabotropic glutamate (mGlu) receptors (types 1 and 5) on NMDA-induced depolarization of mouse cortical wedges in order to characterize the mGlu receptor type responsible for modulating NMDA responses. We also characterized a number of mGlu receptor agents by ...

journal_title：British journal of pharmacology

authors： Attucci S,Carlà V,Mannaioni G,Moroni F

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In terms of postjunctional alpha(2)-adrenoceptors in the pulmonary circulation, no evidence is available with regard to the receptor subtypes mediating vasoconstriction. Therefore, we characterized the alpha(2)-adrenoceptor subtypes mediating contraction in isolated porcine pulmonary veins. EXPE...

journal_title：British journal of pharmacology

authors： Görnemann T,von Wenckstern H,Kleuser B,Villalón CM,Centurión D,Jähnichen S,Pertz HH

更新日期：2007-05-01 00:00:00

abstract：:1. Series of analogues of acetylcholine have been prepared in which the acetyl group was replaced by phenylacetyl, cyclohexylacetyl, diphenylacetyl, dicyclohexylacetyl, (+/-)-phenylcyclohexylacetyl, benziloyl and (+/-)-phenylcyclohexylhydroxyacetyl groups and the trimethylammonium group was replaced by Me(2)EtN(+), Me...

journal_title：British journal of pharmacology

authors： Abramson FB,Barlow RB,Mustafa MG,Stephenson RP

更新日期：1969-09-01 00:00:00

abstract：:1. The effects of (-)-baclofen, muscimol and phaclofen on endogenous gamma-aminobutyric acid (GABA) release from rat cortical slices, spinal cord slices and entire retinas were studied. 2. The spontaneous resting release of GABA from the three tissues was 3 to 6 pmol mg-1 wet wt 10 min-1. Depolarization of cortical sl...

journal_title：British journal of pharmacology

authors： Neal MJ,Shah MA

更新日期：1989-09-01 00:00:00

abstract：:1 New 2H-1,4-benzoxazine derivatives were synthesized and tested for their agonist properties on the ATP-sensitive K(+) channels (K(ATP)) of native rat skeletal muscle fibres by using the patch-clamp technique. The novel modifications involved the introduction at position 2 of the benzoxazine ring of alkyl substituent...

journal_title：British journal of pharmacology

authors： Tricarico D,Barbieri M,Antonio L,Tortorella P,Loiodice F,Camerino DC

更新日期：2003-05-01 00:00:00

abstract：:Proteinase-activated receptor-2 (PAR-2) is expressed throughout the gastrointestinal tract including the pancreas, and may be involved in digestive functions. The aim of our study was to evaluate a potential role for PAR-2 in regulating salivary and pancreatic exocrine secretion in vivo. PAR-2-activating peptides (PAR...

journal_title：British journal of pharmacology

authors： Kawabata A,Nishikawa H,Kuroda R,Kawai K,Hollenberg MD

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Subset of macrophages within the atheroma plaque displays a high glucose uptake activity. Nevertheless, the molecular mechanisms and the pathophysiological significance of this high glucose need remain unclear. While the role for hypoxia and hypoxia inducible factor 1α has been demonstrated, the ...

journal_title：British journal of pharmacology

authors： Ménégaut L,Jalil A,Pilot T,van Dongen K,Crespy V,Steinmetz E,Pais de Barros JP,Geissler A,Le Goff W,Venteclef N,Lagrost L,Gautier T,Thomas C,Masson D

更新日期：2020-12-29 00:00:00

abstract：:1. The effect of the nootropic drug, piracetam on stress- and subsequent morphine-induced prolactin (PRL) secretion was investigated in vivo in male rats, by use of a stress-free blood sampling and drug administration method by means of a permanent indwelling catheter in the right jugular vein. 2. Four doses of pirace...

journal_title：British journal of pharmacology

authors： Matton A,Engelborghs S,Bollengier F,Finné E,Vanhaeist L

更新日期：1996-02-01 00:00:00

abstract：:Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological interventions for their management. More targeted and less invasive therapies...

journal_title：British journal of pharmacology

authors： Rietdorf K,MacQueen H

更新日期：2017-10-01 00:00:00

abstract：:1. We have investigated the in vitro interaction between chloride ions and endothelium as revealed by alterations in vascular contractility and smooth muscle cell membrane potential in isolated pulmonary arteries from Dahl salt-resistant normotensive and salt-sensitive hypertensive rats. 2. Exposure to nitro-l-arginin...

journal_title：British journal of pharmacology

authors： Bieger D,Duggan JA,Tabrizchi R

更新日期：2004-03-01 00:00:00

abstract：:The cardiovascular effects of doxazosin, a quinazoline derivative related to prasozin were investigated and compared to prazosin in the rabbit. Radioligand binding studies using rabbit cerebral membranes showed that both doxazosin and prazosin were roughly equipotent at displacing [3H]-prazosin from specific binding s...

journal_title：British journal of pharmacology

authors： Hamilton CA,Reid JL,Vincent J

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The use of tubulin-binding compounds, which act in part by inhibiting tumour angiogenesis, has become an integral strategy of tumour therapy. Recently, tubulysins were identified as a novel class of natural compounds of myxobacterial origin, which inhibit tubulin polymerization. As these compound...

journal_title：British journal of pharmacology

authors： Rath S,Liebl J,Fürst R,Ullrich A,Burkhart JL,Kazmaier U,Herrmann J,Müller R,Günther M,Schreiner L,Wagner E,Vollmar AM,Zahler S

更新日期：2012-11-01 00:00:00

abstract：:The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent a...

journal_title：British journal of pharmacology

authors： Boullin DJ,Grimes RP,Orr MW

更新日期：1975-12-01 00:00:00

abstract：:1. The effects of 1,3-di(2-tolyl)guanidine (DTG) were examined on the responses of cultured hippocampal neurones to the excitatory amino acid analogues N-methyl-D-aspartate (NMDA), kainate, quisqualate and (RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA). 2. In rat hippocampal neurones loaded with the ...

journal_title：British journal of pharmacology

authors： Fletcher EJ,Church J,Abdel-Hamid K,MacDonald JF

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Leucocyte infiltration is a rate-limiting step in the pathophysiology of acute pancreatitis (AP) although the adhesive mechanisms supporting leucocyte-endothelium interactions in the pancreas remain elusive. The aim of this study was to define the role of lymphocyte function antigen-1 (LFA-1) in ...

journal_title：British journal of pharmacology

authors： Awla D,Abdulla A,Zhang S,Roller J,Menger MD,Regnér S,Thorlacius H

更新日期：2011-05-01 00:00:00

abstract：:1. The effects of the non-selective endothelin (ET) receptor (ETA/ETB) antagonist, bosentan, on sciatic nerve dysfunction in experimental diabetes were investigated. 2. Rats with 5-6 weeks untreated streptozotocin-diabetes exhibited characteristic slowed motor nerve conduction velocity (mean +/- s.d., 36.6 +/- 3.4 m s...

journal_title：British journal of pharmacology

authors： Stevens EJ,Tomlinson DR

更新日期：1995-05-01 00:00:00