Cardiotonic steroids: correlation of sodium-potassium adenosine triphosphate inhibition and ion transport in vitro with inotropic activity and toxicity in dogs.

abstract：:British Journal of Pharmacology (BJP) is pleased to publish a new set of guidelines for reporting research involving animals, simultaneously with several other journals; the 'ARRIVE' guidelines (Animals in Research: Reporting In Vivo Experiments). This editorial summarizes the background to the guidelines, gives our v...

journal_title：British journal of pharmacology

authors： McGrath JC,Drummond GB,McLachlan EM,Kilkenny C,Wainwright CL

更新日期：2010-08-01 00:00:00

abstract：:Antidromic stimulation of sensory peripheral branches of the trigeminal system (mental nerve) leads to cutaneous vasodilatation and increases vascular permeability in the rat. Antidromic vasodilatation is observed only at high intensity stimulation (10 V, 15 Hz, 0.2 or 5 ms) supporting the participation of afferent C-...

journal_title：British journal of pharmacology

authors： Couture R,Cuello AC,Henry JL

更新日期：1985-03-01 00:00:00

abstract：:1. In cortical slices from rat brain incubated in a medium containing the irreversible cholinesterase inhibitor, soman (0.005 mM) and a high concentration of KCl (25 mM), atropine exerts a stimulating action on the release of acetylcholine (ACh).2. Two possible explanations for this action were examined. Atropine migh...

journal_title：British journal of pharmacology

authors： Polak RL

更新日期：1971-04-01 00:00:00

abstract：:1. Isolated preparations of rat anococcygeus muscle were incubated with [3H]-noradrenaline and the efflux of radioactivity induced by stimulation of intramural sympathetic nerves was used as a measure of release of transmitter noradrenaline. Isometric contractile responses were also measured. 2. Angiotensin I (0.03 mi...

journal_title：British journal of pharmacology

authors： Li CG,Majewski H,Rand MJ

更新日期：1988-10-01 00:00:00

abstract：:1. The rat isolated superior mesenteric bed, perfused with Krebs-Henseleit solution containing 10 microM indomethacin and precontracted with 100 microM methoxamine, was used to study the vasorelaxation produced by some fragments of endothelin-1, by two alanyl-substituted analogues, and by human and porcine proendothel...

journal_title：British journal of pharmacology

authors： Douglas SA,Hiley CR

更新日期：1991-10-01 00:00:00

abstract：:1. Heterologous desensitization or intermolecular cross-talk plays a critical role in regulating intracellular signalling by diverse members of the G-protein-coupled receptor superfamily. We have previously established that the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) undergo differential de...

journal_title：British journal of pharmacology

authors： Kelley-Hickie LP,Kinsella BT

更新日期：2004-05-01 00:00:00

abstract：:1. The effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) were investigated on evoked and spontaneous currents in freshly-isolated cells from the rat portal vein by use of conventional whole-cell recording and perforated-patch techniques. 2. At a holding potential of -60 mV in potassium-free, caesium-conta...

journal_title：British journal of pharmacology

authors： Kirkup AJ,Edwards G,Weston AH

更新日期：1996-01-01 00:00:00

abstract：:Leukotriene B4 (LTB4) is a potent leukocyte chemoattractant, acting on specific receptors, BLT receptors. The aim of this study was to examine the mechanism of action of LTB4 in the guinea-pig lung, using strips of lung parenchyma (GPLP), spirals of trachea (GPT) and bronchus (GPB) and rings of pulmonary artery (GPPA)...

journal_title：British journal of pharmacology

authors： Sakata K,Dahlén SE,Bäck M

更新日期：2004-02-01 00:00:00

abstract：:YM471, (Z)-4'-[4,4-difluoro-5-[2-(4-dimethylaminopiperidino)-2-oxoethylidene]-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl]-2-phenylbenzanilide monohydrochloride, is a newly synthesized potent vasopressin (AVP) receptor antagonist. Its effects on binding to and signal transduction by cloned human AVP receptors (V(1...

journal_title：British journal of pharmacology

authors： Tsukada J,Tahara A,Tomura Y,Wada Ki,Kusayama T,Ishii N,Yatsu T,Uchida W,Taniguchi N,Tanaka A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Avoiding danger and finding food are closely related behaviours that are essential for surviving in a natural environment. Growing evidence supports an important role of gut-brain peptides in modulating energy homeostasis and emotional-affective behaviour. For instance, postprandial release of pa...

journal_title：British journal of pharmacology

authors： Verma D,Hörmer B,Bellmann-Sickert K,Thieme V,Beck-Sickinger AG,Herzog H,Sperk G,Tasan RO

更新日期：2016-06-01 00:00:00

abstract：:1 The N6-2-O-dibutyryl derivative of adenosine 3',5'-monophosphate (db cyclic AMP) has been micro-injected into the third cerebral ventricle of the unanaesthetized, restrained mouse and the effects on body temperature and thermoregulatory activities observed. 2 Db cyclic AMP (4, 16 and 32 micrograms) injected intracer...

journal_title：British journal of pharmacology

authors： Dascombe MJ,Milton AS,Nyemitei-Addo I,Pertwee RG

更新日期：1980-11-01 00:00:00

abstract：:To characterize the volume-sensitive, osmolyte permeable anion channels responsible for the osmodependent release of taurine from supraoptic nucleus (SON) astrocytes, we investigated the pharmacological properties of the [(3)H]-taurine efflux from acutely isolated SON. Taurine release induced by hypotonic stimulus (25...

journal_title：British journal of pharmacology

authors： Brès V,Hurbin A,Duvoid A,Orcel H,Moos FC,Rabié A,Hussy N

更新日期：2000-08-01 00:00:00

abstract：:The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation-induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the in...

journal_title：British journal of pharmacology

authors： Marshall RJ,Muir AW,Winslow E

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:PPAR-γ has been reported to be a protective regulator in ischaemia/reperfusion (I/R) injury. The receptor for advanced glycation end-products (RAGE) plays a major role in the innate immune response, and its expression is associated with PPAR-γ activation. Several angiotensin receptor blockers pos...

journal_title：British journal of pharmacology

authors： Koh EJ,Yoon SJ,Lee SM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sphingosine 1-phosphate (S1P), an important inflammatory mediator, has been shown to regulate COX-2 production and promote various cellular responses such as cell migration. Mevastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA), effectively inhibits inflammatory responses...

journal_title：British journal of pharmacology

authors： Hsu CK,Lin CC,Hsiao LD,Yang CM

更新日期：2015-11-01 00:00:00

abstract：:An increasing number of examples in the literature suggest that the in vivo duration of drug action not only depends on macroscopic pharmacokinetic properties like plasma half-life and the time needed to equilibrate between the plasma and the effect compartments, but is also influenced by long-lasting target binding a...

journal_title：British journal of pharmacology

authors： Vauquelin G,Charlton SJ

更新日期：2010-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease where the additional presence of pulmonary hypertension (PH) reduces survival. In particular, the presence of coexistent pulmonary vascular disease in patients with advanced lung parenchymal disease results in worse outcomes than either diagnosis alone. This ...

journal_title：British journal of pharmacology

authors： Rajagopal K,Bryant AJ,Sahay S,Wareing N,Zhou Y,Pandit LM,Karmouty-Quintana H

更新日期：2021-01-01 00:00:00

abstract：:1. The in vitro hemisected spinal cord from young rat was used to investigate the mechanism of serotoninergic modulation of primary afferent-mediated synaptic transmission in the dorsal horn through activation of the 5-HT3 receptor. 2. Dorsal root-evoked excitatory post-synaptic potentials (DR-EPSPs) were recorded int...

journal_title：British journal of pharmacology

authors： Khasabov SG,Lopez-Garcia JA,Asghar AU,King AE

更新日期：1999-06-01 00:00:00

abstract：:The stoichiometric relationship between adrenoceptors and saturable binding sites for 1,4-dihydropyridines in calcium channels was investigated in human ventricular myocardium. Membrane particles were prepared from heart specimens of patients undergoing open heart surgery. The patients suffered from hypertrophic obstr...

journal_title：British journal of pharmacology

authors： Ferry DR,Kaumann AJ

更新日期：1987-03-01 00:00:00

abstract：:1 Depolarizations were recorded intracellularly in smooth muscle from the taenia of the guinea-pig caecum in response to the iontophoretic application of acetylcholine, carbachol, oxotremorine-M, methylfurmethide, hexyl trimethylammonium and tetramethylammonium (TMA). 2 No differences between the iontophoretic respons...

journal_title：British journal of pharmacology

authors： Bolton TB,Clark JP

更新日期：1981-02-01 00:00:00

abstract：:1. Changes in membrane potential (measured with an intracellular microelectrode) and in cyclic nucleotide (adenosine 3':5'-cyclic monophosphate, cyclic AMP and guanosine 3':5'-cyclic monophosphate, cyclic GMP) levels (measured by radioimmunoassay) in response to inhibitory non-adrenergic non-cholinergic (NANC) field s...

journal_title：British journal of pharmacology

authors： Baird AA,Muir TC

更新日期：1990-06-01 00:00:00

abstract：:1. The present study has compared the relative anti-aggregatory effect of various compounds which interfere with thromboxane (Tx) A2-dependent aggregation of human platelets in whole blood in vitro. These included the cyclo-oxygenase inhibitor aspirin, the TxA2 synthase inhibitor dazoxiben, the TxA2 (TP-) receptor blo...

journal_title：British journal of pharmacology

authors： Watts IS,Wharton KA,White BP,Lumley P

更新日期：1991-02-01 00:00:00

abstract：:1. To determine how pretreatment with sulphonylureas alters the beta cell function, mouse islets were cultured (18 - 20 h) without (controls) or with (test) 0.01 microM glibenclamide. Acute responses to glucose were then determined in the absence of glibenclamide. 2. Test islets were insensitive to drugs (sulphonylure...

journal_title：British journal of pharmacology

authors： Anello M,Gilon P,Henquin JC

更新日期：1999-08-01 00:00:00

abstract：:The aims of this study were to develop a technique to measure blood flow in the mouse ear and to investigate the nature of the vasodilator mediator(s) involved in the response to capsaicin. The response to capsaicin, applied topically, was investigated in anaesthetized CD1 or Sv129+C57BL/6 wild-type (+/+) or NK(1) rec...

journal_title：British journal of pharmacology

authors： Grant AD,Gerard NP,Brain SD

更新日期：2002-01-01 00:00:00

abstract：:1. The effect of clofibrate (CFB), bezafibrate (BFB), and gemfibrozil (GFB) on plasma lipoprotein (VLDL and LDL) concentration, composition and resistance to copper-induced oxidation has been studied in male Sprague-Dawley rats after a 15 day treatment. 2. Plasma triglyceride levels were reduced by CFB (41%) and BFB (...

journal_title：British journal of pharmacology

authors： Vázquez M,Merlos M,Adzet T,Laguna JC

更新日期：1996-03-01 00:00:00

abstract：:1. Female mice of the Hough/Porton and Tuck/TO strains were found to be more sensitive than male mice to the diuretic effects of oral and intravenous doses of ethacrynic acid. 2. The sensitivity of Hough/Porton male mice to ethacrynic acid was increased after pretreatment with stilboestrol and the sensitivity of femal...

journal_title：British journal of pharmacology

authors： Cooling MJ,Sim MF

更新日期：1977-08-01 00:00:00

abstract：:1 The activity pattern of analogues of the enkephalins was determined in four parallel assays, the inhibition of the electrically evoked contraction of the guinea-pig ileum and mouse vas deferens at 36 degrees C and the inhibition of [(3)H]-naltrexone and [(3)H]-leucine-enkephalin binding at 0 to 4 degrees C in homoge...

journal_title：British journal of pharmacology

authors： Kosterlitz HW,Lord JA,Paterson SJ,Waterfield AA

更新日期：1980-02-01 00:00:00

abstract：:1. Comparison of the rank order of potency of the natural prostanoids prostaglandin E2 (PGE2), PGD2, PGF2 alpha and carbaprostacyclin in stimulating cyclic AMP in Jurkat cells is consistent with the presence of an EP receptor. 2. Lack of responsiveness to the EP1/EP3 selective agonist, sulprostone, and the EP2 agonist...

journal_title：British journal of pharmacology

authors： De Vries GW,Guarino P,McLaughlin A,Chen J,Andrews S,Woodward DF

更新日期：1995-08-01 00:00:00

abstract：:Fresh human erythrocytes were washed and incubated at 37 degrees C in physiological saline buffered with Tris, containing calcium and either neuraminidase or trypsin or both enzymes together. Each enzyme alone, as well as both together, released similar amounts of sialic acids without haemolysis, apparently therefore ...

journal_title：British journal of pharmacology

authors： Born GV,Housley GM

更新日期：1983-06-01 00:00:00

abstract：:I.c.v. self-administration of MDMA (0.01-2 micro g per infusion), alone and in combination with CP 55,940 (0.4 micro g infusion(-1)), was studied on an operant responding procedure. On the basis of individual preference for one of two levers, developed during training, rats were allowed to self-administer vehicle from...

journal_title：British journal of pharmacology

authors： Braida D,Sala M

更新日期：2002-08-01 00:00:00