Abstract:
:1 The N6-2-O-dibutyryl derivative of adenosine 3',5'-monophosphate (db cyclic AMP) has been micro-injected into the third cerebral ventricle of the unanaesthetized, restrained mouse and the effects on body temperature and thermoregulatory activities observed. 2 Db cyclic AMP (4, 16 and 32 micrograms) injected intracerebroventricularly produced hypothermia when compared with temperature responses to sodium n-butyrate (6.8 micrograms). 3 Hypothermia induced by db cyclic AMP in mice was associated with a fall in oxygen consumption together with behavioural and autonomic heat loss activities but not cutaneous vasodilatation. The effects on rectal temperature and oxygen consumption were dose-dependent. 4 The falls in rectal temperature and oxygen consumption induced by db cyclic AMP (4 micrograms) were decreased by elevation of the environmental temperature from 22 to 32 degrees C and abolished at 36 degrees C. 5 It is concluded db cyclic AMP may inhibit central events mediating the rise in metabolic heat production in mice upon exposure to cold environments.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Dascombe MJ,Milton AS,Nyemitei-Addo I,Pertwee RGdoi
10.1111/j.1476-5381.1980.tb08723.xsubject
Has Abstractpub_date
1980-11-01 00:00:00pages
453-9issue
3eissn
0007-1188issn
1476-5381journal_volume
70pub_type
杂志文章abstract::1. We investigated the effect of KB-R7943, a Na(+)/Ca(2+) exchange inhibitor, on the aggregation response induced by adrenaline and 5-hydroxytryptamine (5-HT), alone or in combination in human and rabbit platelets in the presence or absence of ouabain. 2. KB-R7943 inhibited aggregation induced by the combination of ad...
journal_title:British journal of pharmacology
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journal_title:British journal of pharmacology
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pub_type: 杂志文章,评审
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更新日期:1999-08-01 00:00:00
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更新日期:1988-08-01 00:00:00
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更新日期:2010-04-01 00:00:00
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更新日期:2000-12-01 00:00:00
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更新日期:1985-04-01 00:00:00
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更新日期:1992-10-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
abstract::1. Chronic benzodiazepine administration has been associated with tolerance and with downregulation of gamma-aminobutyric acidA (GABAA)-receptor binding and function. However, effects of individual benzodiazepines on brain regions have varied. 2. To compare the effects of chronic lorazepam and alprazolam, we have admi...
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