Abstract：
:Leukotriene B4 (LTB4) is a potent leukocyte chemoattractant, acting on specific receptors, BLT receptors. The aim of this study was to examine the mechanism of action of LTB4 in the guinea-pig lung, using strips of lung parenchyma (GPLP), spirals of trachea (GPT) and bronchus (GPB) and rings of pulmonary artery (GPPA). Mechanical responses were studied in organ baths, and mediator release was assessed using enzyme immuno assay. LTB4 induced similar contractions of GPLP and GPPA, whereas LTB4 had only small contractile effects in GPT and GPB. In addition, the contractile response to LTB4 was reproduced in the human pulmonary artery. In the GPLP, the unselective BLT receptor antagonist ONO-4057 abolished the contractions induced by LTB4, whereas the selective BLT1 receptor antagonist U-75302 only partly inhibited the LTB4-induced contractions. In the GPPA, both antagonists abolished the response to LTB4. The effect of LTB4 in GPPA and GPLP was indirect and mediated by the release of thromboxane A2 and histamine, as supported by selective pharmacologic interventions and measurements of thromboxane B2 and histamine in the organ baths. In conclusion, the results indicate a new biological function of LTB4, namely to constrict isolated pulmonary arteries. Moreover, the findings suggest that the LTB4-induced contractions of GPPA were mediated by a BLT1 receptor, whereas BLT2 receptor activation accounted for a major part of the contraction of GPLP, making the latter preparation a suitable assay for BLT2 receptors. British Journal of Pharmacology (2004) 141, 449-456. doi:10.1038/sj.bjp.0705641
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Sakata K,Dahlén SE,Bäck Mdoi
10.1038/sj.bjp.0705641subject
Has Abstractpub_date
2004-02-01 00:00:00pages
449-56issue
3eissn
0007-1188issn
1476-5381pii
sj.bjp.0705641journal_volume
141pub_type
杂志文章abstract：BACKGROUND AND PURPOSE:Patients commonly take complementary medicines in conjunction with warfarin yet evidence supporting the safety or the risk of a herb-drug interaction is lacking. The aim of this study was to investigate the possible impact of two commonly used herbal medicines, garlic and cranberry, on the pharma...
journal_title：British journal of pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjp.2008.210
更新日期：2008-08-01 00:00:00
abstract：:1. Desensitization of the myocardial beta-adrenergic signal transduction pathway is an important mechanism which is involved in the progression of hypertensive heart disease. The aim of the present study was to evaluate the differential effects of chronic pharmacotherapy with an angiotensin converting enzyme (ACE)-inh...
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doi：10.1038/sj.bjp.0706023
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doi：10.1111/j.1476-5381.1996.tb15343.x
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1973.tb06915.x
更新日期：1973-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1983.tb11022.x
更新日期：1983-06-01 00:00:00
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journal_title：British journal of pharmacology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1991.tb12166.x
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pub_type： 评论,杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1988-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1972.tb07286.x
更新日期：1972-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1993.tb13892.x
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1979.tb16089.x
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doi：10.1111/j.1476-5381.1993.tb12836.x
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更新日期：2017-12-01 00:00:00
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doi：10.1111/j.1476-5381.1984.tb10101.x
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doi：10.1038/sj.bjp.0705604
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-03-11 00:00:00
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pub_type： 杂志文章
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更新日期：1980-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1476-5381.1990.tb14195.x
更新日期：1990-12-01 00:00:00
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更新日期：2005-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
