Abstract:
:1. The effects of chronic oral administration of desmethylimipramine (DMI) or zimelidine (1.25 and 5 mg kg-1 twice daily for 21 days) were studied on rat whole cortical gamma-aminobutyric acidB (GABAB) binding sites. No changes in receptor affinity or number were found with either drug. 2. A subsequent study of GABAB binding sites using higher doses of these drugs (5 and 10 mg kg-1) and rat frontal cortex was also without effect, when investigated 24 h after termination of drug administration or 72 h after DMI administration (5 mg kg-1). 3. The number of frontal cortical 5-hydroxytryptamine2 (5-HT2) binding sites was significantly and dose-dependently decreased after both drugs, whereas the number of hippocampal 5-HT2 binding sites was not significantly altered after either drug. 4. As the number of frontal cortical GABAB binding sites was unaltered whereas the number of 5-HT2 binding sites was significantly decreased under identical study conditions, it may be concluded that the effects of antidepressant administration upon GABAB binding sites is a less consistent observation than their effects on 5-HT2 binding sites.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Cross JA,Horton RWdoi
10.1111/j.1476-5381.1988.tb11438.xsubject
Has Abstractpub_date
1988-02-01 00:00:00pages
331-6issue
2eissn
0007-1188issn
1476-5381journal_volume
93pub_type
杂志文章abstract::1. The cardiovascular effects of bilateral injection into the hypothalamic paraventricular nuclei of selective mu-, delta-, and kappa-opioid receptor agonists were investigated in conscious, unrestrained Wistar Kyoto rats, chronically instrumented with pulsed Doppler flow probes for measurement of regional haemodynami...
journal_title:British journal of pharmacology
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abstract::Recent clinical studies have demonstrated that angiotensin II type 1 (AT(1) ) receptor blockers (ARBs) reduce the onset of stroke, stroke severity and the incidence and progression of Alzheimer's disease and dementia. We can expect that ARBs exert these effects by both AT(1) receptor blockade and angiotensin II type 2...
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journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1971.tb08055.x
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更新日期:1981-06-01 00:00:00
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更新日期:1991-04-01 00:00:00
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更新日期:2016-04-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1988.tb11461.x
更新日期:1988-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-03-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:2012-05-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/bph.13652
更新日期:2017-01-01 00:00:00