The effects of postligation administration of ORG 6001 and disopyramide on early ischaemia-induced arrhythmias in the anaesthetized rat.

Abstract:

:The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation-induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the incidence of ventricular fibrilloflutter and completely prevented electrical deaths (45% in the controls). Protection was also seen when the drugs were given just before the expected onset of arrhythmias (4.5 min postligation).

journal_name

Br J Pharmacol

authors

Marshall RJ,Muir AW,Winslow E

doi

10.1111/j.1476-5381.1982.tb09245.x

subject

Has Abstract

pub_date

1982-08-01 00:00:00

pages

501-3

issue

4

eissn

0007-1188

issn

1476-5381

journal_volume

76

pub_type

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