Enhancement of opioid inhibition of GABAergic synaptic transmission by cyclo-oxygenase inhibitors in rat periaqueductal grey neurones.

abstract：:Antigen challenge in vivo of rat peritoneal cells (enriched with monocytes and polymorphonuclear leucocytes) passively sensitized 2 h previously with homologous antibody of the IgGa class released large amounts of slow-reacting substance of anaphylaxis (SRS-A, 1739 +/- 59 u/ml) into the peritoneal fluid. This reaction...

journal_title：British journal of pharmacology

authors： Burka JF,Garland LG

更新日期：1977-12-01 00:00:00

abstract：:1. The effects of the selective alpha 2-adrenoceptor agonist, medetomidine, were assessed on plasma levels of immunoreactive atrial natriuretic peptide (IR-ANP), haemodynamics and on urine water and solute excretion in conscious, chronically cannulated, 7 month-old spontaneously hypertensive (SHR) and age-matched Wist...

journal_title：British journal of pharmacology

authors： Ruskoaho H,Leppäluoto J

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intrathecal administration of alpha(2)-adrenoceptor agonists produces potent analgesia. This study addressed the subtype of spinal alpha(2)-adrenoceptor responsible for the analgesic effects of i.t. dexmedetomidine and ST-91 in the formalin behavioural model and their effects on primary afferent ...

journal_title：British journal of pharmacology

authors： Nazarian A,Christianson CA,Hua XY,Yaksh TL

更新日期：2008-12-01 00:00:00

abstract：:1. To clarify the role of the first thrombin receptor/protease-activated receptor (PAR)-1 in an inflammatory process, we tested and characterized the effect of intraplantar (i.pl.) administration of the highly specific PAR-1 agonist TFLLR-NH2 in rat hindpaw. 2. TFLLR-NH2 administered i.pl. at 0.01-0.03 micromol per pa...

journal_title：British journal of pharmacology

authors： Kawabata A,Kuroda R,Nishikawa H,Asai T,Kataoka K,Taneda M

更新日期：1999-04-01 00:00:00

abstract：:1. Mild stress plus mild pain (solvent injection) applied daily to neonatal mice induces hormonal, behavioural and metabolic changes perduring in the adult life. 2. We investigated whether daily mild stress to neonatal mice induces also long-term defined changes of immune response, and whether immune changes are preve...

journal_title：British journal of pharmacology

authors： Loizzo A,Loizzo S,Lopez L,d'Amore A,Renzi P,Spampinato S,Di Carlo S,Bacosi A,Zuccaro P,Pacifici R

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Rho kinase (ROCK) activation is involved in neuroinflammatory processes leading to progression of neurodegenerative diseases such as Parkinson's disease. Furthermore, ROCK plays a major role in angiogenesis. Neuroinflammation and angiogenesis are mechanisms involved in developing l-DOPA-induced d...

journal_title：British journal of pharmacology

authors： Lopez-Lopez A,Labandeira CM,Labandeira-Garcia JL,Muñoz A

更新日期：2020-12-01 00:00:00

abstract：:1. The irritant fungal terpenoid isovelleral caused protective eye-wiping movements in the rat upon intraocular instillation and showed cross-tachyphylaxis with capsaicin, the pungent principle in hot pepper. 2. Isovelleral induced a dose-dependent calcium uptake by rat dorsal root ganglion neurones cultured in vitro ...

journal_title：British journal of pharmacology

authors： Szallasi A,Jonassohn M,Acs G,Bíró T,Acs P,Blumberg PM,Sterner O

更新日期：1996-09-01 00:00:00

abstract：:1. Inhibition of nitric oxide generation with Nw-nitro-L-arginine (nitroarginine) reduced vasodilator responses to bradykinin and acetylcholine and enhanced those to nitroprusside in the rat isolated perfused kidney, preconstricted with phenylephrine. 2. Inhibition of cyclo-oxygenase with indomethacin, decreased the v...

journal_title：British journal of pharmacology

authors： Fulton D,McGiff JC,Quilley J

更新日期：1992-11-01 00:00:00

abstract：:1. The effects of different K+ channel blockers were studied on nitric oxide (NO)-mediated non-adrenergic non-cholinergic (NANC) relaxations in the canine ileocolonic junction. 2. The non-selective blockers of K+ channels, 4-aminopyridine (4-AP) and tetraethylammonium (TEA) and the blocker of large conductance Ca(2+)-...

journal_title：British journal of pharmacology

authors： De Man JG,Boeckxstaens GE,Pelckmans PP,De Winter BY,Herman AG,Van Maercke YM

更新日期：1993-10-01 00:00:00

abstract：:1. Patients with airway infection by Pseudomonas aeruginosa have impaired mucociliary clearance. Pyocyanin is a phenazine pigment produced by P. aeruginosa which is present in the sputum of colonized patients, slows human ciliary beat frequency (CBF) in vitro and slows mucociliary transport in vivo in the guinea-pig. ...

journal_title：British journal of pharmacology

authors： Kanthakumar K,Cundell DR,Johnson M,Wills PJ,Taylor GW,Cole PJ,Wilson R

更新日期：1994-06-01 00:00:00

abstract：:1. The diversity of alpha(2) and purinergic autoreceptor actions on action potential evoked calcium transients in single varicosities has been investigated using the calcium indicator Oregon Green 488 BAPTA-1. 2. During long trains of impulses (10 Hz for 30 s), the change in calcium concentration in varicosities from ...

journal_title：British journal of pharmacology

authors： O'Connor SC,Brain KL,Bennett MR

更新日期：1999-12-01 00:00:00

abstract：:1. The alpha 2-adrenoceptor binding sites of rabbit spleen and rat kidney, labelled with [3H]-rauwolscine, were characterized using a range of subtype selective ligands. 2. In rabbit spleen, the alpha-2-adrenoceptor binding sites displayed high affinity for oxymetazoline and WB 4101 and low affinity for prazosin and c...

journal_title：British journal of pharmacology

authors： Michel AD,Loury DN,Whiting RL

更新日期：1990-03-01 00:00:00

abstract：:1. The atrioventricular node (AVN) is an important part of the conduction system in the heart and is a significant site of antiarrhythmic drug action. The class 1 antiarrhythmic propafenone is effective in treating a variety of arrhythmias, including those involving the AVN. In this study, we have investigated the eff...

journal_title：British journal of pharmacology

authors： Hancox JC,Mitcheson JS

更新日期：1997-05-01 00:00:00

abstract：:1. Whole-cell patch-clamp recordings were made from smooth muscle cells isolated from the longitudinal muscle layer of guinea-pig ileum. Carbachol (acting at muscarinic receptors) or histamine (acting at H1 histamine receptors) suppressed Ca2+ channel current. The effect of either agonist had an initial transient comp...

journal_title：British journal of pharmacology

authors： Unno T,Beech DJ,Komori S,Ohashi H

更新日期：1998-10-01 00:00:00

abstract：:The histamine H3 receptor, first described in 1983 as a histamine autoreceptor and later shown to also function as a heteroreceptor that regulates the release of other neurotransmitters, has been the focus of research by numerous laboratories as it represents an attractive drug target for a number of indications inclu...

journal_title：British journal of pharmacology

authors： Esbenshade TA,Browman KE,Bitner RS,Strakhova M,Cowart MD,Brioni JD

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sublesional osteoporosis predisposes individuals with spinal cord injury (SCI) to an increased risk of low-trauma fracture. The aim of the present work was to investigate the effect of treatment with resveratrol (RES) on sublesional bone loss in spinal cord-injured rats. EXPERIMENTAL APPROACH:Co...

journal_title：British journal of pharmacology

authors： Wang HD,Shi YM,Li L,Guo JD,Zhang YP,Hou SX

更新日期：2013-10-01 00:00:00

abstract：:1. Using gene chip technology, we first identified that PGF(2alpha) (FP agonist) and Butaprost (EP(2) agonist) induced about a five-fold upregulation of Nur77 mRNA expression in hFP-HEK 293/EBNA and hEP(2)-HEK293/EBNA cells. Northern Blot analysis revealed that PGF(2alpha)- and Butaprost-induced upregulation of Nur77 ...

journal_title：British journal of pharmacology

authors： Liang Y,Li C,Guzman VM,Chang WW,Evinger AJ,Pablo JV,Woodward DF

更新日期：2004-06-01 00:00:00

abstract：:1 Burimamide injected intravenously in the anaesthetized or conscious cat produced significant increases in gastric acid secretion: in the anaesthetized cat it produced increased gastric mucosal blood flow. 2 Metiamide, in doses which inhibited pentagastrin-stimulated acid secretion, produced no increase in gastric ac...

journal_title：British journal of pharmacology

authors： Harris DW,Smy JR,Reed JD,Venables CW

更新日期：1975-02-01 00:00:00

abstract：:Allergic inflammatory responses contribute to the symptoms of a number of diseases including atopic dermatitis, asthma and rhinitis. Cationic proteins are released from inflammatory cells and levels are known to be raised in disease states. Using an in vivo model of acute inflammation, we investigated the characterist...

journal_title：British journal of pharmacology

authors： Jones H,Paul W,Page CP

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Calcitonin gene-related peptide (CGRP) is a potent vasodilator, implicated in the pathogenesis of migraine. CGRP activates a receptor complex comprising, calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1). In vitro studies indicate recycling of CLR●RAMP1 is ...

journal_title：British journal of pharmacology

authors： McNeish AJ,Roux BT,Aylett SB,Van Den Brink AM,Cottrell GS

更新日期：2012-12-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) increased adenosine 3' : 5'-cyclic monophosphate (cyclic AMP) formation in tracheal epithelial cells and concomitantly decreased the production/secretion of immunoreactive endothelin (irET). Naturally occurring prostanoids and selective and non-selective EP receptor agonists showed the foll...

journal_title：British journal of pharmacology

authors： Pelletier S,Dubé J,Villeneuve A,Gobeil F Jr,Yang Q,Battistini B,Guillemette G,Sirois P

更新日期：2001-03-01 00:00:00

abstract：:1. Prostaglandins and the vasodilator neuropeptide, calcitonin-gene related peptide (CGRP), have both been implicated in the pathogenesis of migraine headache. We have used primary cultures of adult rat trigeminal neurones to examine the effects of prostanoids on CGRP release in vitro. 2. CGRP release was stimulated b...

journal_title：British journal of pharmacology

authors： Jenkins DW,Feniuk W,Humphrey PP

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Immunomodulatory tetracyclines are well-characterized drugs with a pharmacological potential beyond their antibiotic properties. Specifically, minocycline and doxycycline have shown beneficial effects in experimental colitis, although pro-inflammatory actions have also been described in macrophag...

journal_title：British journal of pharmacology

authors： Garrido-Mesa J,Rodríguez-Nogales A,Algieri F,Vezza T,Hidalgo-Garcia L,Garrido-Barros M,Utrilla MP,Garcia F,Chueca N,Rodriguez-Cabezas ME,Garrido-Mesa N,Gálvez J

更新日期：2018-12-01 00:00:00

abstract：:1. The influence of different holding potentials (-120 to -70 mV) on the contraction of enzymatically dispersed myocytes from guinea-pig hearts was evaluated. Contractions were elicited by repetitive depolarizations to 0 mV at 0.5 Hz. 2. While ineffective at 140 and 5 mmol l-1 [Na+]o and pipette Na+, respectively, dep...

journal_title：British journal of pharmacology

authors： Mermi J,Yajima M,Ebner F

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Catechol-O-methyltransferase (COMT) inhibitors are used in Parkinson's disease in which pain is an important symptom. COMT polymorphisms modulate pain and opioid analgesia in humans. In rats, COMT inhibitors have been shown to be pro-nociceptive in acute pain models, but also to attenuate allodyn...

journal_title：British journal of pharmacology

authors： Kambur O,Talka R,Ansah OB,Kontinen VK,Pertovaara A,Kalso E,Männistö PT

更新日期：2010-12-01 00:00:00

abstract：:1 The spasmogenic and spasmolytic effects of beta-lipotropin (LPH) fragments and one analogue were investigated on different parts of the gastro-intestinal tract of guinea-pig and rat in vitro.2 Changes in muscle tone were observed in colon and rectum and to a lesser extent in jejunum and ileum of both species. Rat co...

journal_title：British journal of pharmacology

authors： Nijkamp FP,Van Ree JM

更新日期：1980-04-01 00:00:00

abstract：:AM-36 is a novel neuroprotective agent incorporating both antioxidant and Na(+) channel blocking actions. In cerebral ischaemia, loss of cellular ion homeostasis due to Na(+) channel activation, together with increased reactive oxygen species (ROS) production, are thought to contribute to neuronal death. Since neurona...

journal_title：British journal of pharmacology

authors： Callaway JK,Beart PM,Jarrott B,Giardina SF

更新日期：2001-04-01 00:00:00

abstract：:1. We studied the stereoselectivity of the effects of the enantiomers of the cardiotonic agent DPI 201-106 (4-[3'-(4"-benzhydryl-1"-piperazinyl)-2'-hydroxypropoxy]-1H-indole-2- carbonitrile, DPI) and its methyl-for-carbonitrile analogue BDF 8784 on cardiac calcium currents (ICa) of guinea-pig ventricular myocytes. The...

journal_title：British journal of pharmacology

authors： Ravens U,Pfeifer T,Wettwer E,Grundke M

更新日期：1991-10-01 00:00:00

abstract：:1 Endothelin-1 (ET-1), an endothelium-derived vasoactive peptide, participates in the regulation of endothelial function through mechanisms that are not fully elucidated. This study examined the impact of ET-1 on oxidative stress, apoptosis and cell proliferation in human umbilical vein endothelial cells (HUVEC). HUVE...

journal_title：British journal of pharmacology

authors： Dong F,Zhang X,Wold LE,Ren Q,Zhang Z,Ren J

更新日期：2005-06-01 00:00:00

abstract：:1--Responses (relaxation) to the beta-adrenoceptor agonists, isoprenaline, fenoterol or noradrenaline, were obtained on cat tracheal preparations contracted with a submaximal concentration of carbachol (0.5 microM). 2--The relative potencies of isoprenaline: fenoterol: noradrenaline were 100:8.1:10.7. From this, it wa...

journal_title：British journal of pharmacology

authors： O'Donnell SR,Wanstall JC

更新日期：1983-02-01 00:00:00